Navigation Links
Researchers develop drug delivery system using nanoparticles triggered by electromagnetic field
Date:7/8/2010

KINGSTON, R.I. July 8, 2010 A new system for the controlled delivery of pharmaceutical drugs has been developed by a team of University of Rhode Island chemical engineers using nanoparticles embedded in a liposome that can be triggered by non-invasive electromagnetic fields.

The discovery by URI professors Geoffrey Bothun and Arijit Bose and graduate student Yanjing Chen was published in the June issue of ACS Nano.

According to Bothun, liposomes are tiny nanoscale spherical structures made of lipids that can trap different drug molecules inside them for use in delivering those drugs to targeted locations in the body. The superparamagnetic iron oxide nanoparticles the researchers embed in the shell of the liposome release the drug by making the shell leaky when heat-activated in an alternating current electromagnetic field operating at radio frequencies.

"We've shown that we can control the rate and extent of the release of a model drug molecule by varying the nanoparticle loading and the magnetic field strength," explained Bothun. "We get a quick release of the drug with magnetic field heating in a matter of 30 to 40 minutes, and without heating there is minimal spontaneous leakage of the drug from the liposome."

Bothun said that the liposomes self-assemble because portions of the lipids are hydrophilic they have a strong affinity for water and others are hydrophobic they avoid water. When he mixes lipids and nanoparticles in a solvent, adds water and evaporates off the solvent, the materials automatically assemble themselves into liposomes. The hydrophobic nanoparticles and lipids join together to form the shell of the liposome, while the water-loving drug molecules are captured inside the spherical shell.

"The concept of loading nanoparticles within the hydrophobic shell to focus the activation is brand new," Bothun said. "It works because the leakiness of the shell is ultimately what controls the release of the drugs."

The next step in the research is to design and optimize liposome/nanoparticle assemblies that can target cancer cells or other disease-causing cells. In vitro cancer cell studies are already underway in collaboration with URI pharmacy professor Matthew Stoner.

"We are functionalizing the liposomes by putting in different lipids to help stabilize and target them so they can seek out particular cancer cell types," he said. "We are building liposomes that will attach to particular cells or tumor regions."

Bothun said that research on nanomedicine shows great promise, but there are still many challenges to overcome, and the targeting of appropriate cells may be the greatest challenge.

"Any ability to target the drug is better than a drug that goes everywhere in your system and generates off-target effects," he said, noting that the hair loss and nausea from anti-cancer drugs are the result of the high drug concentrations needed for treatment and the drug's affect on non-target cells. "If you can get an assembly to a targeted site without losing its contents in the process, that's the holy grail."


'/>"/>

Contact: Shane Donaldson
sdonaldson@advance.uri.edu
401-874-2116
University of Rhode Island
Source:Eurekalert

Related biology news :

1. NC State researchers get to root of parasite genome
2. Researchers find animal with ability to survive climate change
3. Researchers find an essential gene for forming ears of corn
4. Researchers note differences between people and animals on calorie restriction
5. Researchers study acoustic communication in deep-sea fish
6. Researchers discover that growing up too fast may mean dying young in honey bees
7. Researchers study how pistachios may improve heart health
8. UI researchers find potentially toxic substance present in Chicago air
9. Researchers develop new self-training gene prediction program for fungi
10. Case Western Reserve University researchers track Chernobyl fallout
11. Childrens National researchers develop novel anti-tumor vaccine
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/9/2016)... TURKU, Finland , June 9, 2016 ... French National Police deploy Teleste,s video security solution to ensure ... France during the major tournament ... and data communications systems and services, announced today that its ... Police Prefecture to back up public safety across ...
(Date:6/2/2016)... --  The Weather Company , an IBM Business (NYSE: ... in which consumers will be able to interact with IBM ... voice or text and receive relevant information about the product ... have long sought an advertising solution that can create a ... and valuable; and can scale across millions of interactions and ...
(Date:5/20/2016)... , May 20, 2016  VoiceIt is excited ... with VoicePass. By working together, VoiceIt ...  Because VoiceIt and VoicePass take slightly different approaches ... increases both security and usability. ... about this new partnership. "This marketing ...
Breaking Biology News(10 mins):
(Date:6/24/2016)... 24, 2016  Regular discussions on a range of subjects ... the two entities said Poloz. Speaking at a ... , he pointed to the country,s inflation target, which ... "In certain areas ... have common economic goals, why not sit down and address ...
(Date:6/24/2016)... ... 24, 2016 , ... While the majority of commercial spectrophotometers and fluorometers use ... 6000i models are higher end machines that use the more unconventional z-dimension of 20mm. ... from the bottom of the cuvette holder. , FireflySci has developed several Agilent ...
(Date:6/23/2016)... ... June 23, 2016 , ... Mosio, a ... eBook, “Clinical Trials Patient Recruitment and Retention Tips.” Partnering with experienced clinical research ... by providing practical tips, tools, and strategies for clinical researchers. , “The landscape ...
(Date:6/23/2016)...   Boston Biomedical , an industry leader ... target cancer stemness pathways, announced that its lead ... Designation from the U.S. Food and Drug Administration ... gastroesophageal junction (GEJ) cancer. Napabucasin is an orally ... stemness pathways by targeting STAT3, and is currently ...
Breaking Biology Technology: