Navigation Links
Researchers develop better control for DNA-based computations

A North Carolina State University chemist has found a way to give DNA-based computing better control over logic operations. His work could lead to interfacing DNA-based computing with traditional silicon-based computing.

The idea of using DNA molecules the material genes are made of to perform computations is not new; scientists have been working on it for over a decade. DNA has the ability to store much more data than conventional silicon-based computers, as well as the potential to perform calculations in a biological environment inside a live cell, for example. But while the technology holds much promise, it is still limited in terms of the ability to control when and where particular computations occur.

Dr. Alex Deiters, associate professor of chemistry at NC State, developed a method for controlling a logic gate within a DNA-based computing system. Logic gates are the means by which computers "compute," as sets of them are combined in different ways to enable the computer to ultimately perform tasks like addition or subtraction. In DNA computing, these same types of gates are created by the combinations of different strands of DNA, rather than by a series of transistors. The drawback is that DNA computation events normally take place in a test tube, where the sequence of computation events cannot be easily controlled with spatial and temporal resolution. So while DNA logic gates can and do work, no one can tell them when or where to work, making it difficult to create sequences of computational events.

In a paper published in the Journal of the American Chemical Society, Deiters addressed the control problem by making portions of the input strands of DNA logic gates photoactivatable, or controllable by ultraviolet (UV) light. The process is known as photocaging. Deiters successfully photocaged several different nucleotides on a DNA logic gate known as an AND gate. When UV light was applied to the gate, it was activated and completed its computational event, showing that photoactivatable logic gates offer an effective solution to the "when and where" issues of DNA-based logic gate control.

Deiters hopes that using light to control DNA logic gates will give researchers the ability not only to create more complicated, sequential DNA computations, but also to create interfaces between silicon and DNA-based computers.

"Since the DNA gates are activated by light, it should be possible to trigger a DNA computation event by converting electrical impulses from a silicon-based computer into light, allowing the interaction of electrical circuits and biological systems," Deiters says.

"Being able to control these DNA events both temporally and spatially gives us a variety of new ways to program DNA computers."

Contact: Tracey Peake
North Carolina State University

Related biology news :

1. NC State researchers get to root of parasite genome
2. Researchers find animal with ability to survive climate change
3. Researchers find an essential gene for forming ears of corn
4. Researchers note differences between people and animals on calorie restriction
5. Researchers study acoustic communication in deep-sea fish
6. Researchers discover that growing up too fast may mean dying young in honey bees
7. Researchers study how pistachios may improve heart health
8. UI researchers find potentially toxic substance present in Chicago air
9. Researchers develop new self-training gene prediction program for fungi
10. Case Western Reserve University researchers track Chernobyl fallout
11. Childrens National researchers develop novel anti-tumor vaccine
Post Your Comments:
(Date:6/16/2016)... June 16, 2016 The ... expected to reach USD 1.83 billion by 2024, ... Research, Inc. Technological proliferation and increasing demand in ... expected to drive the market growth. ... The development of advanced multimodal techniques for ...
(Date:6/3/2016)... , June 3, 2016 ... von Nepal hat ... Lieferung hochsicherer geprägter Kennzeichen, einschließlich Personalisierung, Registrierung ... in der Produktion und Implementierung von Identitätsmanagementlösungen. ... Ausschreibung im Januar teilgenommen, aber Decatur wurde ...
(Date:5/24/2016)... Ampronix facilitates superior patient care by providing unparalleled technology to leaders of ... the latest premium product recently added to the range of products distributed by Ampronix. ... ... ... Medical Display- Ampronix News ...
Breaking Biology News(10 mins):
(Date:6/24/2016)... TOKYO , June 24, 2016  Regular discussions on ... to take place between the two entities said Poloz. ... in Ottawa , he pointed to the ... and the federal government. ... Poloz said, "Both institutions have common economic goals, why not ...
(Date:6/24/2016)... ... June 24, 2016 , ... While the majority of commercial spectrophotometers and ... and the 6000i models are higher end machines that use the more unconventional z-dimension ... light beam from the bottom of the cuvette holder. , FireflySci has developed ...
(Date:6/23/2016)... WA (PRWEB) , ... June 23, 2016 , ... ... announces the release of its second eBook, “Clinical Trials Patient Recruitment and Retention ... recruitment and retention in this eBook by providing practical tips, tools, and strategies ...
(Date:6/23/2016)... , June 23, 2016   Boston ... of novel compounds designed to target cancer stemness ... has been granted Orphan Drug Designation from the ... treatment of gastric cancer, including gastroesophageal junction (GEJ) ... inhibitor designed to inhibit cancer stemness pathways by ...
Breaking Biology Technology: