Navigation Links
Researchers determine why tendons break down with age
Date:8/5/2014

Scientists at Queen Mary University of London (QMUL) have identified differences in the proteins present in young and old tendons, in new research that could guide the development of treatments to stop tissue breakdown from occurring.

Tendon structure in horses is similar to humans, and both face common injuries. The researchers used a horse model to undertake a thorough analysis of all the proteins and protein fragments present in healthy and injured tendons.

Working with scientists at the University of Liverpool, the team collected data, which shows that healthy, older tendons have a greater amount of fragmented material within them, suggesting accumulated damage over time that has not been fully repaired.

When examining injured tendons, the team found even more evidence of protein breakdown. However, whilst in younger tendons, the cells were active and trying to repair the damage, there was an accumulation of different protein fragments in older tendons. This suggests the cells somehow lose the ability to repair damage during the ageing process.

"Normal function of tendons, such as the Achilles, is important not just for Commonwealth athletes but for everyday activities for ordinary people," said co-author Dr Hazel Screen, a Reader in biomedical engineering at QMUL's School of Engineering and Materials Science and Institute of Bioengineering.

She added: "This is the first study of its kind, and provides evidence that the increased risk of tendon injury with ageing might be due to a reduced ability of tendon cells to repair damage effectively."

This novel information is an important first step towards understanding how our tissues break down as we age and could help us find ways to prevent it occurring in the future.


'/>"/>
Contact: Neha Okhandiar
n.okhandiar@qmul.ac.uk
020-788-27927
Queen Mary, University of London
Source:Eurekalert

Page: 1

Related biology news :

1. Study by UC Santa Barbara researchers suggests that bacteria communicate by touch
2. UC Santa Barbara researchers discover genetic link between visual pathways of hydras and humans
3. Researchers attempt to solve problems of antibiotic resistance and bee deaths in one
4. UNH researchers find African farmers need better climate change data to improve farming practices
5. Ottawa researchers to lead world-first clinical trial of stem cell therapy for septic shock
6. Researchers uncover molecular pathway through which common yeast becomes fungal pathogen
7. Researchers print live cells with a standard inkjet printer
8. Columbia Engineering and Penn researchers increase speed of single-molecule measurements
9. Researchers reveal how a single gene mutation leads to uncontrolled obesity
10. Researchers discover novel therapy for Crohns disease
11. New paper by Notre Dame researchers describes method for cleaning up nuclear waste
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/22/2016)... 2016 On Monday, the Department of Homeland ... share solutions for the Biometric Exit Program. The Request ... Protection (CBP), explains that CBP intends to add biometrics ... the United States , in order to deter ... Logo - http://photos.prnewswire.com/prnh/20160622/382209LOGO ...
(Date:6/15/2016)... ALBANY, New York , June 15, 2016 ... published a new market report titled "Gesture Recognition Market ... Trends and Forecast, 2016 - 2024". According to the ... at USD 11.60 billion in 2015 and is ... and reach USD 48.56 billion by 2024.  ...
(Date:6/3/2016)... 2016 Das DOTM ... Nepal hat ein 44 Millionen ... Kennzeichen, einschließlich Personalisierung, Registrierung und IT-Infrastruktur, an ... und Implementierung von Identitätsmanagementlösungen. Zahlreiche renommierte internationale ... teilgenommen, aber Decatur wurde als konformste und ...
Breaking Biology News(10 mins):
(Date:6/23/2016)... ... , ... In a new case report published today in STEM CELLS Translational ... lymphedema after being treated for breast cancer benefitted from an injection of stem cells ... this debilitating, frequent side effect of cancer treatment. , Lymphedema refers to ...
(Date:6/23/2016)... BEACH, Calif. , June 23, 2016  Blueprint ... new biological discoveries to the medical community, has closed ... co-founder Matthew Nunez . "We have ... us with the capital we need to meet our ... will essentially provide us the runway to complete validation ...
(Date:6/23/2016)... , June 23, 2016 On ... session at 4,833.32, down 0.22%; the Dow Jones Industrial Average ... 500 closed at 2,085.45, down 0.17%. Stock-Callers.com has initiated coverage ... INFI ), Nektar Therapeutics (NASDAQ: NKTR ), Aralez ... Inc. (NASDAQ: BIND ). Learn more about these ...
(Date:6/23/2016)... ... June 23, 2016 , ... ... regulatory and technical consulting, provides a free webinar on Performing Quality ... 13, 2016 at 12pm CT at no charge. , Incomplete investigations are still ...
Breaking Biology Technology: