Navigation Links
Researchers determine why tendons break down with age
Date:8/5/2014

Scientists at Queen Mary University of London (QMUL) have identified differences in the proteins present in young and old tendons, in new research that could guide the development of treatments to stop tissue breakdown from occurring.

Tendon structure in horses is similar to humans, and both face common injuries. The researchers used a horse model to undertake a thorough analysis of all the proteins and protein fragments present in healthy and injured tendons.

Working with scientists at the University of Liverpool, the team collected data, which shows that healthy, older tendons have a greater amount of fragmented material within them, suggesting accumulated damage over time that has not been fully repaired.

When examining injured tendons, the team found even more evidence of protein breakdown. However, whilst in younger tendons, the cells were active and trying to repair the damage, there was an accumulation of different protein fragments in older tendons. This suggests the cells somehow lose the ability to repair damage during the ageing process.

"Normal function of tendons, such as the Achilles, is important not just for Commonwealth athletes but for everyday activities for ordinary people," said co-author Dr Hazel Screen, a Reader in biomedical engineering at QMUL's School of Engineering and Materials Science and Institute of Bioengineering.

She added: "This is the first study of its kind, and provides evidence that the increased risk of tendon injury with ageing might be due to a reduced ability of tendon cells to repair damage effectively."

This novel information is an important first step towards understanding how our tissues break down as we age and could help us find ways to prevent it occurring in the future.


'/>"/>
Contact: Neha Okhandiar
n.okhandiar@qmul.ac.uk
020-788-27927
Queen Mary, University of London
Source:Eurekalert

Page: 1

Related biology news :

1. Study by UC Santa Barbara researchers suggests that bacteria communicate by touch
2. UC Santa Barbara researchers discover genetic link between visual pathways of hydras and humans
3. Researchers attempt to solve problems of antibiotic resistance and bee deaths in one
4. UNH researchers find African farmers need better climate change data to improve farming practices
5. Ottawa researchers to lead world-first clinical trial of stem cell therapy for septic shock
6. Researchers uncover molecular pathway through which common yeast becomes fungal pathogen
7. Researchers print live cells with a standard inkjet printer
8. Columbia Engineering and Penn researchers increase speed of single-molecule measurements
9. Researchers reveal how a single gene mutation leads to uncontrolled obesity
10. Researchers discover novel therapy for Crohns disease
11. New paper by Notre Dame researchers describes method for cleaning up nuclear waste
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/30/2017)... -- On April 6-7, 2017, Sequencing.com will host the world,s ... at Microsoft,s headquarters in Redmond, Washington ... health and wellness apps that provide a unique, personalized ... is the first hackathon for personal genomics and the ... the genomics, tech and health industries are sending teams ...
(Date:3/29/2017)...  higi, the health IT company that operates the ... , today announced a Series B investment from ... The new investment and acquisition accelerates higi,s strategy to ... population health activities through the collection and workflow integration ... collects and secures data today on behalf of over ...
(Date:3/24/2017)... The Controller General of Immigration from Maldives Mr. ... have received the prestigious international IAIR Award for the most innovative ... ... Maldives Immigration ... Algeen (small picture on the right) have received the IAIR award for ...
Breaking Biology News(10 mins):
(Date:7/20/2017)... ... July 20, 2017 , ... Resoundant, Inc. is pleased ... centers around the U.S. that offer MR Elastography for liver fibrosis staging. ... biopsy for staging liver fibrosis assessment. , “MRE:connect was created in response to ...
(Date:7/20/2017)... ... July 20, 2017 , ... ... digital pathology and artificial intelligence Tuesday, July 25, during the Association of Pathology ... Johns Hopkins Medicine. , Baras, Associate Director of Pathology Informatics, will present ...
(Date:7/18/2017)... , ... July 18, 2017 , ... ... accelerate pharmaceutical and biotherapeutics development, announces the launch of a new NTA biosensor ... chip enables researchers to study the kinetics of polyhistidine-tagged (His-tagged) molecules quickly and ...
(Date:7/18/2017)... ... ... Blood centers traditionally see a dangerous drop of blood donations during the ... community blood centers as high schools are out and many frequent donors are on ... up with the South Texas Blood & Tissue Center (STBTC), a subsidiary ...
Breaking Biology Technology: