Navigation Links
Researchers design first model motor nerve system that's insulated and organized like the human body
Date:7/21/2009

Amsterdam, 21 July 2009 - In the July issue of Biomaterials, published by Elsevier, researchers from the University of Central Florida (UCF) report on the first lab-grown motor nerves that are insulated and organized just like they are in the human body. The model system will drastically improve understanding of the causes of myelin-related conditions, such as diabetic neuropathy and later, possibly multiple sclerosis (MS). In addition, the model system will enable the discovery and testing of new drug therapies for these conditions.

MS, diabetic neuropathy, and many conditions that are caused by a loss of myelin, which forms protective insulation around our nerves, can be debilitating and even deadly. Adequate treatments do not yet exist. Researchers at the UCF have identified this to be a result of a deficiency in model research systems.

James Hickman, a bioengineer at UCF and the lead researcher on this project explained: "The nodes of Ranvier act like power station relays along the myelin sheath. They chemically boost signals, allowing them to get across breaks in myelin, or from node to node, at the electrically charged nodes of Ranvier. Nerve malfunctions, called neuropathies, involve a breakdown in the way the brain sends and receives electric signals along nerve cells, leading to malfunctions at the nodes of Ranvier, along with demyelination". Hickman's team has now achieved the first successful model nodes of Ranvier formation on motor nerves in a defined serum-free culture system.

Researchers have long recognized the need for lab-grown motor nerve cells that myelinate and form nodes of Ranvier in order to use controlled lab conditions to zero in on the causes of demyelination. Yet, due to the complexity of the nervous system, it has been a challenge to study demyelinating neuropathies, and researchers have been confined to using animal models.

The main difference with this research was that Hickman's gro
'/>"/>

Contact: Allyn Molina
Al.molina@elsevier.com
212-366-3656
Elsevier
Source:Eurekalert

Page: 1 2

Related biology news :

1. Iowa State University researchers develop process for surgical genetic changes
2. UCLA researchers discover new molecular pathway for targeting cancer, disease
3. Munich researchers discover new target for tailored antibiotics
4. Baylor researchers unravel mystery of DNA conformation
5. Researchers achieve major breakthrough with water desalination system
6. Researchers gain insight into mechanism underlying Huntingtons
7. Alzheimers disease drug treats traumatic brain injury, report GUMC researchers
8. UTSA infectious disease researchers advancing vaccine against Valley fever
9. Canadian researchers set to study impact of nanomaterials on aquatic ecosystems
10. Ben-Gurion U. researchers reveal connection between cancer and human evolution
11. University of Leicester researchers discover new fluorescent silicon nanoparticles
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/15/2014)... for both plants and animals alike. , Understanding just ... lead to the design of better drugs for diabetes ... and vegetables farmers are able to grow. Stanford University ... the cell by piecing together proteins slightly wider than ... To determine the size, shape and orientation of one ...
(Date:9/15/2014)... ecologists fears that reef biodiversity may not provide the ... thought. , In an international study published today, Professor ... Coral Reef Studies (Coral CoE) says we need to ... ecosystems. , In coral reefs, just as in any ... ecosystem safe and functioning. , Professor Bellwood says, ...
(Date:9/15/2014)... the first 500 million years after it formed may ... with oceans, continents and active crustal plates. , This ... Hadean, has gained substantial new support from the first ... 4 billion years ago with those formed contemporaneously in ... analog for early Earth. , The study was conducted ...
Breaking Biology News(10 mins):X-rays unlock a protein's SWEET side 2X-rays unlock a protein's SWEET side 3Specialized species critical for reefs 2Early Earth less hellish than previously thought 2Early Earth less hellish than previously thought 3
... chief executive officer of DuPont, and Abby Joseph Cohen, ... & Co., will be featured speakers at a University ... to be held Friday, Nov. 2, in Clayton Hall, ... conference is the first in a new series of ...
... of marine microbes have been discovered at two deep-sea ... the MBL (Marine Biological Laboratory) and University of Washingtons ... Their findings, published in the October 5 issue of ... comprehensive, comparative study to date of deep-sea microbial communities ...
... (ESA) is proud to announce its selection of ... as an ESA Fellow acknowledges outstanding contributions in research, ... have have participated actively in ESA affairs and served ... be recognized during the ESA Annual Meeting, which will ...
Cached Biology News:UD hosts conference on knowledge-based partnerships Nov. 2 2Hydrothermal vents: Hot spots of microbial diversity 2Entomological Society of America recognizes 2007 fellows and honorary members 2Entomological Society of America recognizes 2007 fellows and honorary members 3
(Date:9/15/2014)... Carolina State University have developed a technique for controlling ... low voltages, opening the door to a new generation ... technique hinges on the fact that the oxide "skin" ... removed acts as a surfactant, lowering the surface ... The researchers used a liquid metal alloy of gallium ...
(Date:9/15/2014)... 15, 2014 Zymo Research Corp., has announced ... for safe ambient temperature storage and transport of ... infectivity of agents in such samples is completely ... of the viral nucleic acids for subsequent analyses.  ... epidemic in West Africa ...
(Date:9/15/2014)... 15. September 2014 Die zweite jährliche ... vom 12. bis 18. Oktober stattfinden. Die IPAW ... Therapeutics Association (PPTA) und ihrer Mitgliedsunternehmen ... Das globale Bewusstsein für die Gewinnung von Quellplasma ... beim Retten und Verbessern von Leben zu würdigen ...
(Date:9/14/2014)... MD (PRWEB) September 15, 2014 ... be held on Tuesday, October 21, 2014, from 12:00 ... overview of the program’s innovative curriculum and practice-oriented instruction, ... a graduate degree can help advance their career in ... RSVP online . , About UMBC’s Biotechnology ...
Breaking Biology Technology:Researchers control surface tension to manipulate liquid metals 2Safe storage and transport of Ebola, Mers-CoV, and other viruses: Groundbreaking viral inactivation solution capable of preserving nucleic acids 2Safe storage and transport of Ebola, Mers-CoV, and other viruses: Groundbreaking viral inactivation solution capable of preserving nucleic acids 3International Plasma Awareness Week feiert Spender und rückt seltene Krankheiten in den Mittelpunkt 2International Plasma Awareness Week feiert Spender und rückt seltene Krankheiten in den Mittelpunkt 3UMBC Biotechnology Graduate Programs’ Virtual Info Session, October 21, 2014 2
... (Nasdaq: VNDA ), a biopharmaceutical company focused ... for central,nervous system disorders, today announced financial and ... 2008., Vanda reported research and development (R&D) ... million, compared to $5.5 million in the second,quarter ...
... STERIS Corporation,(NYSE: STE ) today announced financial ... 2008. Fiscal 2009 second quarter revenues,increased 10% to $323.1 ... fiscal 2008, driven by strong growth in all three ... million, or $0.48,per diluted share, compared with net income ...
... Genetic Variations Identify Predisposition to Early Cardiovascular,Events in ... Interleukin Genetics,Inc. (Amex: ILI ), announced today ... will present new research findings on,the genetics of ... Symposium (CVGAS), which takes place from Oct. 31 ...
Cached Biology Technology:Vanda Pharmaceuticals Reports Third Quarter 2008 Results 2Vanda Pharmaceuticals Reports Third Quarter 2008 Results 3Vanda Pharmaceuticals Reports Third Quarter 2008 Results 4Vanda Pharmaceuticals Reports Third Quarter 2008 Results 5Vanda Pharmaceuticals Reports Third Quarter 2008 Results 6Vanda Pharmaceuticals Reports Third Quarter 2008 Results 7Vanda Pharmaceuticals Reports Third Quarter 2008 Results 8Vanda Pharmaceuticals Reports Third Quarter 2008 Results 9Vanda Pharmaceuticals Reports Third Quarter 2008 Results 10STERIS Corporation Announces Fiscal 2009 Second Quarter and First Half Results 2STERIS Corporation Announces Fiscal 2009 Second Quarter and First Half Results 3STERIS Corporation Announces Fiscal 2009 Second Quarter and First Half Results 4STERIS Corporation Announces Fiscal 2009 Second Quarter and First Half Results 5STERIS Corporation Announces Fiscal 2009 Second Quarter and First Half Results 6STERIS Corporation Announces Fiscal 2009 Second Quarter and First Half Results 7STERIS Corporation Announces Fiscal 2009 Second Quarter and First Half Results 8STERIS Corporation Announces Fiscal 2009 Second Quarter and First Half Results 9STERIS Corporation Announces Fiscal 2009 Second Quarter and First Half Results 10STERIS Corporation Announces Fiscal 2009 Second Quarter and First Half Results 11Interleukin Genetics to Present New Findings at the 11th Cardiovascular Genomics and Atherosclerosis Symposium 2Interleukin Genetics to Present New Findings at the 11th Cardiovascular Genomics and Atherosclerosis Symposium 3Interleukin Genetics to Present New Findings at the 11th Cardiovascular Genomics and Atherosclerosis Symposium 4
Applications: Western blotting ...
...
... efficiencies and the chemistry of light production ... benefit that they require simple triggering conditions ... This benefit has been exploited to great ... compounds can also be easily modified to ...
ssDNA from PCR DNA in less than 1 hour. No gels, columns, or slurries. Sequence from high quality ssDNA: clearer reads, longer runs....
Biology Products: