Navigation Links
Researchers design drug to restore cell suicide in HPV-related head and neck cancer
Date:4/8/2013

the function of the p53 "tumor-suppressor" gene and triggers the death of the cancer cells.

"Our study revealed a new mechanism for p53 inactivation in HPV-positive head and neck cancer, and this allowed us to develop an agent that disrupts that interaction and reactivates p53 in HPV-positive head and neck cancer," Pan says. "Our pre-clinical studies show CH1iB can reactivate p53 and eliminate HPV-positive head and neck cancer cells."

Pan notes that the standard of care for HPV-positive head and neck cancer uses high-dose cis-platinum, a chemotherapy drug that causes serious side effects that are difficult for patients to tolerate. The drug's toxicity raises the need for safer therapy, and, although further testing is necessary, combining CH1iB with a low dose of cis-platinum might one day provide an alternative.

For this study, Pan and his colleagues used high-risk HPV-positive head and neck squamous cell carcinoma cells. Key technical findings include:

  • The small-molecule inhibitor CH1iB inhibits the binding of the HPV E6 protein with the p300 cell protein;

  • The binding of the CH1iB inhibitor with p300 reactivated p53 and dramatically potentiated the efficacy of cis-platinum in HPV-positive head and neck cancer cells.

  • The combination of CH1iB and cis-platinum eliminated 91 percent of HPV16-positive head and neck cancer cells; it also increased apoptosis by 984 percent and 443 percent compared with CH1iB and cis-platinum respectively alone.

"These results suggest that fewer cycles or a tapered dose of cis-platinum, along with a CH1 inhibitor, might be sufficient to effectively manage HPV-positive head and neck cancer patients and offer a better toxicity profile," Pan says.

"Taken together, our data suggest that we've discovered a novel approach for reactivating the p53 gene in HPV-positive head and neck cancer that may translate to other HPV-positive carcinomas."


'/>"/>

Contact: Darrell E. Ward
darrell.ward@osumc.edu
614-293-3737
Ohio State University Medical Center
Source:Eurekalert

Page: 1 2

Related biology news :

1. Researchers shine light on how stress circuits learn
2. Cleveland Clinic researchers discover new link between heart disease and red meat
3. SFU researchers help unlock pine beetles Pandoras box
4. Empa researchers join Quantis to open new branch in Switzerland
5. MDC and FMP researchers identify edema inhibitor
6. Barrow researchers identify
7. Researchers discover brain cancer treatment using genetic material from bone marrow cells
8. Notre Dame researchers are using new technologies to combat invasive species
9. University of Montreal researchers discover how drug prevents aging and cancer progression
10. Researchers question evaluation methods for protected areas in the Amazon
11. Penn Researchers attach Lyme disease antibodies to nanotubes, paving way for diagnostic device
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/19/2014)... and Markets ( http://www.researchandmarkets.com/research/86ncd6/micro_market ) has announced ... America Perimeter Security Systems Market" report to their ... The North American perimeter security market is estimated ... to 2019. Although the U.S. market holds a larger ... is expected to grow at a higher CAGR of ...
(Date:12/17/2014)... Dec. 15, 2014  HITLAB SM announced ... (GCP) audit to confirm its adherence to current ... accomplishment enables HITLAB to conduct regulated smart device ... principles for patient safety and research quality. ... access, quality, and delivery with innovative technology," said ...
(Date:12/11/2014)... , Dec. 09, 2014 Research and ... ( http://www.researchandmarkets.com/research/twhjll/biometrics_market ) has ... in the APAC Region 2015-2019"  report to their ... in this market is advances in technology. With ... upgrade biometric solutions to the latest standard that ...
Breaking Biology News(10 mins):Micro Market Monitor: North America Perimeter Security Systems Market (Intrusion Detection Sensor, Video Surveillance, Communication/Alarm and Notification, Access Control System) 2Micro Market Monitor: North America Perimeter Security Systems Market (Intrusion Detection Sensor, Video Surveillance, Communication/Alarm and Notification, Access Control System) 3HITLAB Completes GCP Audit for FDA Smart Device & App Compliance 2Biometrics Market in the APAC Region 2015-2019: Key Vendors are 3M Cogent, NEC, Safran and Suprema 2
... The increasing acidity of the world,s oceans and ... definitive proof that the atmospheric carbon dioxide that is ... environment, says world-renowned Antarctic marine biologist Jim McClintock, Ph.D., ... Department of Biology. "The oceans are a sink ...
... , PARIS , Feb. 4 ... network for Eurofins Scientific, a global leader in bio-analysis. , ... will securely connect 16 key Eurofins laboratories and research centers ... with the company,s global customer base.  Verizon will use MPLS ...
... COLLEGE STATION A joke among two Texas ... found Viagra can aid fetal development in female sheep. ... can serve as an excellent animal model for studying ... Viagra (sildenafil citrate), which is used to treat male ...
Cached Biology News:Oceans reveal further impacts of climate change, says UAB expert 2Oceans reveal further impacts of climate change, says UAB expert 3Verizon Business to Provide Global IP for Eurofins Scientific 2Verizon Business to Provide Global IP for Eurofins Scientific 3Study shows male erectile dysfunction drug enhances fetal growth in female sheep 2
(Date:12/22/2014)... Dec. 22, 2014  ( www.competitivehealth.com ) — Competitive ... medical bill review and advocacy service, has signed an ... WellCard Savings discount health services marketplace. 63% ... more than they expected to pay. As part of ... costs, WellCard Savings is pleased to offer medical bill ...
(Date:12/22/2014)... 22, 2014 Fertility Associates of Memphis ... Bank USA , a network of more than 20 ... partnership, patients have fast access to a national pool ... IVF . Fertility Associates of Memphis is the only ... treatment option. , Dr. William Kutteh , director ...
(Date:12/19/2014)... BioPlus Specialty Pharmacy (BioPlus), one ... of Nick Maroulis, Pharm.D. to the newly created position ... In this position, Dr. Maroulis will continue to manage ... of our multi-site pharmacies as the company expands. Dr. ... that time he has served in many different capacities ...
(Date:12/19/2014)... Dec. 19, 2014 Bina Technologies, Inc. (Bina, ... that they have been acquired by Roche (SIX: RO, ... privately held company that provides a big data platform ... (NGS) data for the academic and translational research markets. ... and will continue to focus on development of their ...
Breaking Biology Technology:WellCard Savings Announces CoPatient Medical Bill Review Service for Members 2Fertility Associates of Memphis Announces Partnership with Donor Egg Bank USA 2Fertility Associates of Memphis Announces Partnership with Donor Egg Bank USA 3BioPlus Specialty Pharmacy Promotes Dr. Nick Maroulis to Vice President of Specialty Pharmacy Services 2Bina Technologies is acquired by Roche. 2Bina Technologies is acquired by Roche. 3
... 2011 Sequenom, Inc. (NASDAQ: SQNM ), a ... the Company,s participation at the Lazard Capital Markets 8th Annual ... November 15-16, 2011. Harry F. Hixson, Jr, Ph.D., ... EVP of Research and Development, will present on Tuesday, November ...
... of active metamaterial that incorporates semiconductor devices into conventional ... gain while retaining its negative refraction property, a first ... and experimental results show that the addition of the ... also maintained the negative index of this kind of ...
... 9, 2011 A new diagnostic kit ... been launched at the Veterinary Cancer Society,s annual conference ... ) in the UK, the announcement is a significant ... major benefit being that it is able to differentiate ...
Cached Biology Technology:Sequenom Announces Participation at the Lazard Capital Markets 8th Annual Healthcare Conference 2New metamaterial allows transmission gain while retaining negative refraction property 2New Kit Takes the Uncertainty Out of Lymphoma Diagnosis 2
Rabbit polyclonal to Peptide E ( Abpromise for all tested applications)....
Mouse monoclonal [6911] to E. coli K99 pilus ( Abpromise for all tested applications)....
...
...
Biology Products: