Navigation Links
Researchers describe new molecular interactions behind the inhibition of TGF beta-signaling
Date:8/24/2012

This press release is available in Spanish.

Researchers headed by Maria Macias an ICREA researcher at the Institute for Research in Biomedicine (IRB Barcelona) and Joan Massagu, a Howard Hughes Medical Institute investigator at Memorial Sloan-Kettering Cancer Center (MSKCC) in New York, have identified a new molecular mechanism that plays a crucial role in the control of the activation of certain genes associated with cancer.

Through detailed structural and biochemical studies, the researchers identified a key domain present in a family of proteins called Smads, whose binding determines whether the transcription of genes controlled by the TGF-beta and BMP signaling cascades will be bound by activators or labeled for degradation. These processes are critical to the correct development and maintenance of tissues and organisms.

When looking at inhibitory Smads , the researchers found that the specific domain binds directly and constitutively to their targets. This is in contrast to what happens with receptor-activated Smads, where the proteins must first undergo processing by phosphorylation a chemical change whereby the proteins are first activated and then labeled for degradation after completing their transcriptional function. The study appears online today (August 23) in the journal Structure.

Smads are key proteins in the signaling pathways of the hormones TGF-beta and BMP, which are known to participate in the control of stem cell pluripotency and differentiation and in the development and maintenance of metazoan organisms. In this study, the researchers looked at the interactions of Smad7 a protein inhibitor of TGF-beta signaling with molecules implicated in the cascade, including three ubiquitin ligases and YAP, a transcription coactivator. They identified the domains in the four proteins that interact with the same re
'/>"/>

Contact: Sarah Sherwood
sarah.sherwood@irbbarcelona.org
34-934-034-636
Institute for Research in Biomedicine (IRB Barcelona)
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. U of M researchers: Newly discovered genetic markers could signal colon cancer development
2. Iowa State, Ames Lab researchers study the structure of drug resistance in tuberculosis
3. ORNL researchers improve soil carbon cycling models
4. Researchers identify key culprit causing muscle atrophy
5. Researchers demonstrate control of devastating cassava virus in Africa
6. Researchers pursue red flag for schizophrenia relapse
7. A new line of defense: Researchers find cattle vaccine works to reduce E. coli O157:H7
8. Iowa State, Ames Lab researchers invent new tool to study single biological molecules
9. Wayne State researchers working to improve genetic analysis, disorder detection
10. Superbird stuns researchers
11. Massachusetts Eye and Ear researchers discover elusive gene that causes a form of blindness from birth
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/17/2014)... N.C. , Dec. 16, 2014 Valencell, a ... its PerformTek biometric technology to industry leaders such as ... accurate, clinically validated, biometric wearable products. These products will ... in Las Vegas . ...
(Date:12/11/2014)... Markets , http://photos.prnewswire.com/prnh/20130307/600769 ... addition of the "Biometrics Market in the APAC ... One major trend emerging in this market is advances ... important to upgrade biometric solutions to the latest standard ...
(Date:12/10/2014)... been here before: you desperately need to sign into your online ... answer to your secret question. What,s your dog,s birthday? Who was ... , a digital infrastructure security company, launches the app ... with usernames, passwords and PINs – 1U TM . ...
Breaking Biology News(10 mins):Valencell PerformTek Biometrics Power the Most Accurate Wearables at CES 2015 2Biometrics Market in the APAC Region 2015-2019: Key Vendors are 3M Cogent, NEC, Safran and Suprema 2The Password is Finally Dead: Launch of 1U Mobile App Eliminates Need for All Usernames and Passwords 2The Password is Finally Dead: Launch of 1U Mobile App Eliminates Need for All Usernames and Passwords 3
... and their colleagues in Japan are conducting research that may ... necessary step if man someday hopes to build molecular machines ... Dr. Eric Blough, a member of the research ... Biological Sciences, said his group has shown how bionanomotors can ...
... Biologists have known for long that ecology, the interaction ... in forming new species and in modifying living ones. ... The environment defines a template and the process of ... template. Some specialized theory, a few ...
... plant virus lures aphids to infected plants by making the ... they quickly leave for tastier, healthier ones. In the process, ... entomologists. "The virus improves the cues that insects use to ... is already in the plant," said Mark C. Mescher, assistant ...
Cached Biology News:Research at Marshall University may lead to new ways to transport and manipulate molecules 2Research at Marshall University may lead to new ways to transport and manipulate molecules 3Evolution impacts environment, challenging traditionally held view, UC Riverside study finds 2Evolution impacts environment, challenging traditionally held view, UC Riverside study finds 3Virus pulls bait and switch on insect vectors 2Virus pulls bait and switch on insect vectors 3
(Date:1/22/2015)... Nueva Jersey , 22 de enero de 2015  El ... abre hoy su llamada a nominaciones para 2015. Este ... ha hecho, o tiene el potencial para hacer, contribuciones ... nominaciones se aceptarán hasta el 15 de marzo de ...
(Date:12/25/2014)... The report “Service Quality Management and ... Provider Type - Global Advancements, Worldwide Forecasts & Analysis ... analysis and forecasting of revenues. , Browse 152 ... and in-depth TOC on “Service Quality Management (SQM) and ...
(Date:12/24/2014)... “Preparative & Process Chromatography Market ... (Columns, Solvents, Buffers, Valves, Guages, Seals), Accessories, Services, ... Forecasts to 2019” provides a detailed overview of ... trends, and strategies impacting the preparative and process ...
(Date:12/24/2014)... (PRWEB) December 23, 2014 According to Ross ... Island Affiliate of ITRA Global, the national office market continues ... recovery. This is evidenced by the third quarter’s surprising ... market. Low energy costs have held inflation down and ...
Breaking Biology Technology:El Dr. Paul Janssen Award for Biomedical Research emite su llamada a los nominados para 2015 2El Dr. Paul Janssen Award for Biomedical Research emite su llamada a los nominados para 2015 3El Dr. Paul Janssen Award for Biomedical Research emite su llamada a los nominados para 2015 4Service Quality Management Market worth $2.1 Billion & Telco Customer Experience Management Market worth $2.3 Billion by 2019 – New Report by MarketsandMarkets 2Service Quality Management Market worth $2.1 Billion & Telco Customer Experience Management Market worth $2.3 Billion by 2019 – New Report by MarketsandMarkets 3Service Quality Management Market worth $2.1 Billion & Telco Customer Experience Management Market worth $2.3 Billion by 2019 – New Report by MarketsandMarkets 4Preparative and Process Chromatography Market is expected to reach $9 billion by 2019 - New Report by Marketsandmarkets 2Preparative and Process Chromatography Market is expected to reach $9 billion by 2019 - New Report by Marketsandmarkets 3Preparative and Process Chromatography Market is expected to reach $9 billion by 2019 - New Report by Marketsandmarkets 4ITRA Global Reports Long Island Is Out of Sync With The National Office Market 2ITRA Global Reports Long Island Is Out of Sync With The National Office Market 3
... , EATONTOWN, N.J., July 29 Osteotech, ... emerging field of biologic products for regenerative healing, today announced ... the French regulatory agency, afssaps, rescinded its December 17, 2008 ... products processed from donors procured by TB OsteoCentre Bulgaria EAD ...
... , , , ... (Nasdaq: VRNM ) today announced that its 50-50 ... and plan to relocate its corporate headquarters to Florida. Vercipia ... nation,s first commercial-scale cellulosic ethanol facilities, located in Highlands County, ...
... VAN BUREN TWP., Mich. , July 29 ... plc, the leading independent provider of technology, product innovation and ... energy industries, has announced that the company is to launch ... engine technologies. With the environmental demand to reduce CO2 emissions ...
Cached Biology Technology:Osteotech Resumes Shipments of Bulgarian Tissue 2Osteotech Resumes Shipments of Bulgarian Tissue 3BP and Verenium Announce Vercipia Biofuels to Advance the Commercialization of Cellulosic Ethanol 2BP and Verenium Announce Vercipia Biofuels to Advance the Commercialization of Cellulosic Ethanol 3BP and Verenium Announce Vercipia Biofuels to Advance the Commercialization of Cellulosic Ethanol 4Ricardo Launches Consortium to Evaluate Lubricant Challenges of Future Low Carbon Engine Technologies 2Ricardo Launches Consortium to Evaluate Lubricant Challenges of Future Low Carbon Engine Technologies 3
... anti-phospho-FAK (Ser843) ... acid region encompassing the human, mouse, ... Accession Number: NM_153831 ... Routinely evaluated by immunoblot. ...
Molecular Biology grade. Ideally suited for DNA and RNA separation and recovery. High gel strength. Gelling temp. 36C. Melting temp. 88C. EEO: 0.05-0.13 Resolution 0.2-40 kb; Rnase/Dnase: none detec...
Rabbit polyclonal to Quinolinic acid ( Abpromise for all tested applications). Antigen: Synthetic quinolinic acid conjugated to bovine serum albumin....
Phospho-YAP (Ser127) Antibody Ship: Hot Store: -20 C...
Biology Products: