Navigation Links
Researchers describe 1 mechanism that favors rejection in transplantation of porcine cartilage in humans
Date:11/25/2013

Researchers at the Bellvitge Institute of Biomedical Research (IDIBELL) led by Cristina Costa from the New Therapies on Genes and Transplantation group have shown that inhibition of one of the basic components of the complement system protects chondrocytes (cartilage cells) from porcine rejection of xenotransplantation (transplantation between animals of different species).

Complement system

The complement system is a key component in the process of innate immunity. "This is the first response of the organism to external pathogens," explained Cristina Costa " and in recent years there have been very relevant jobs that establish that the complement system may be an important therapeutic target in diseases of cartilage." In that vein, the group Cristina Costa works in xenotransplantation research of cartilage cells (chondrocytes) pig in human joints that have suffered a traumatic injury. This particular work shows that one of the components of the complement system effectors: C5 plays a major role in the rejection.

In a first phase the researchers inhibited pharmacologically C5 in an experimental mouse model and injected them with porcine chondrocytes. "We note that there is a protective effect. The animals without C5 present more preserved cartilage tissue and less cellular infiltrate. "

Description of the mechanism

After confirming the protective effect of C5 inhibition, the researchers studied the molecular mechanisms which enable this component of the innate immune response are. The studies were conducted by exposing porcine chondrocytes in human serum " so that the results bring us one step closer to clinical application " noted Costa .

"We found that activation of the human complement system not directly cause cell death of porcine chondrocytes but activates various inflammatory processes, adhesion and secretion of cytokines and chemokines. All related to xenograft rejection. "

Cartilage transplant

Cartilage transplantation between humans is not widely applied in the clinic but has already proved successful in the regeneration of this tissue in traumatic injuries, especially in athletes. Autologous transplants are performed (with cells from the same person) or allogeneic (cells from another person). "In both cases," explains Cristina Costa " the limitation is in the number of cells. If we get that xenotransplantation work we increase the number and quality of cells available for transplantation. "

In the future, according to the researcher, "maybe we could apply the xenotransplantation of porcine chondrocytes patients of osteoarthritis or even rheumatoid arthritis " but has warned Costa "in these cases other inflammatory and immunological processes that hinder the success of transplantation are combined."


'/>"/>

Contact: Arantxa Mena
amena@idibell.cat
0034-932-607-129
IDIBELL-Bellvitge Biomedical Research Institute
Source:Eurekalert  

Related biology news :

1. UCLA, Emory researchers find a chemical signature for fast form of Parkinsons
2. Researchers map brain areas vital to understanding language
3. Researchers gain fuller picture of cell protein reactions
4. Scripps oceanography researchers engineer breakthrough for biofuel production
5. USF researchers show invasive sparrows immune cells sharpen as they spread
6. Researchers use CT and 3-D printers to recreate dinosaur fossils
7. Natural compound mitigates effects of methamphetamine abuse, University of Missouri researchers find
8. Researchers classify urban residential desert landscapes
9. Researchers test effects of LEDs on leaf lettuce
10. Researchers develop new approach to identify possible ecological effects of releasing genetically engineered insects
11. Researchers capture structure of key part of deadly Nipah virus
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Researchers describe 1 mechanism that favors rejection in transplantation of porcine cartilage in humans
(Date:12/2/2016)... The report "Biometric Vehicle Access ... (Iris Recognition System), Vehicle Type (Passenger Car, Battery ... 2021", published by MarketsandMarkets, the market is estimated ... is projected to grow to USD 854.8 Million ...      (Logo: http://photos.prnewswire.com/prnh/20160303/792302) ...
(Date:11/30/2016)...  higi SH llc (higi) announced today the ... brands, industry thought-leaders and celebrity influencers looking to ... taking steps to live healthier, more active lives. ... has built the largest self-screening health station network ... who have conducted over 185 million biometric screenings.  ...
(Date:11/29/2016)... , November 29, 2016 Nearly one billion ... Continue Reading ... ... part of an efficient Identity Management. (PRNewsFoto/DERMALOG Identification Systems) ... DERMALOG is Germany's largest Multi-Biometric supplier: The ...
Breaking Biology News(10 mins):
(Date:12/8/2016)... San Francisco, CA (PRWEB) , ... December 08, ... ... and Oculus as finalists in the World Technology Awards. uBiome is one of ... were received across all categories. , In addition to uBiome, companies nominated as ...
(Date:12/8/2016)... , Dec. 8, 2016 Savannah ... remediation technologies and selected NewTechBio,s NT-MAX Lake ... microbial based beneficial bacteria, in conjunction with Hexa ... correct deficiencies with National Pollutant Discharge Elimination System ... has experienced a steady history of elevated pH ...
(Date:12/7/2016)... (PRWEB) , ... December 07, 2016 , ... ... journal has concluded that “in the setting of previously treated, advanced pancreatic cancer, ... in defining the optimal patient population and timing of blood sampling may improve ...
(Date:12/7/2016)... Ontario , Dec. 7, 2016  Nordion, ... with General Atomics (GA), welcome today,s award by ... Nuclear Security Administration (NNSA) of the Phase II ... project with Nordion and the University of Missouri ... II funding will support the establishment of a ...
Breaking Biology Technology: