Navigation Links
Researchers demystifying complex cellular communications hubs found in sensory neurons
Date:7/7/2010

BETHESDA, Md., July 6, 2010 It's safe to say that cilia, the hairlike appendages jutting out from the smooth surfaces of most mammalian cells, have long been misunderstood underestimated, even.

Not to be confused with their whiplike cousins flagella, which propel sperm, one type of cilia has been known to serve as microscopic conveyor belts. (Picture cilia reaching up like concertgoers supporting a crowd-surfer.) But for decades another type of cilia, known as "primary" cilia, was believed to serve little to no purpose. Despite the fact that almost every cell found in vertebrates has at least one primary cilium, the organ was regarded as merely an evolutionary relic the cellular equivalent to the human appendix.

Of late, however, it has become increasingly clear that primary cilia serve as powerful communication hubs. (After all, they do sort of look like antennae.) Disruptions in the activity of cilia are now understood to lead to a whole class of diseases dubbed ciliopathies, and researchers are hustling to figure out what makes them tick.

One group of scientists in Japan last month marked a milestone in the pursuit to reveal cilia's secrets. In study results that were fast-tracked for publication and deemed a "Paper of the Week" by the Journal of Biological Chemistry, they report that they have identified a long-elusive enzyme necessary for the proper regulation of cilia.

The Hamamatsu University School of Medicine team is optimistic that the discovery may aid in the development of therapies for those with visual and hearing maladies caused by cilia dysfunction.

"Our finding might give insights into the sensory defects associated with problems in cilia function. For example, patients with some syndromes have genetic defects in cilia functions that result in retinal degeneration," explains Mitsutoshi Setou, who oversaw the team's work. "Also, age-dependent visual loss or hearing loss is known to be r
'/>"/>

Contact: Angela Hopp
ahopp@asbmb.org
301-634-7389
American Society for Biochemistry and Molecular Biology
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Pitt researchers find new proteins that regulate blood pressure, flow
2. Rutgers researchers discover secrets of nutritious corn breed that withstands rigors of handling
3. Researchers discover trigger to early, effective antibody response
4. Hips dont lie: Researchers find more accurate technique to determine sex of skeletal remains
5. WSU researchers use super-high pressures to create super battery
6. Cell signaling classification system gives researchers new tool
7. Researchers discover how insulin-producing cells increase during pregnancy
8. Researchers develop accurate way to predict the age when women will hit the menopause
9. Researchers discover source of essential nutrients for mid-ocean algae
10. Researchers at UH work to prevent neurological diseases
11. Researchers create self-assembling nanodevices that move and change shape on demand
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/14/2014)... How does oxygen control insect body size? What influence does ... first issue of Current Opinion in Insect Science ... questions. , Current Opinion in Insect Science is ... is a review journal that aims to provide specialists with ... of information published in the field of insect science. First ...
(Date:7/14/2014)... Foundation (BGRF), a UK-based charity founded to support ... rapidly ageing population, hosted the inaugural 21st Century ... Analytics, a company supporting financial decision-making in the ... at the forum included: , Dmitry Kamenskiy, Senior ... Investment to Advance Longevity Research, , Kate Elizarova, ...
(Date:7/14/2014)... University of Kansas scientists to the discovery and description of ... in collections specimen, which turned out to represent a new ... enigmatic ripidiine wedge beetle from Borneo is discussed in a ... ZooKeys . , The holotype male, and only known ... ago in Borneo but subsequent to this it was transferred ...
Breaking Biology News(10 mins):BGRF hosts inaugural 21st Century Medicine Forum 2Serendipity at the Smithsonian: The 107-year journey of the beetle Rhipidocyrtus muiri 2Serendipity at the Smithsonian: The 107-year journey of the beetle Rhipidocyrtus muiri 3
... space activities, a silent revolution is taking place at ... first human-rated spacecraft to be launched from Europe,s Spaceport, ... pressurised module of the largest, most complex automated spacecraft ... fulfilling the most stringent rules of human spaceflight. , ...
... to pass genes to the next generation. In sexually ... that are vital for fertility. In a new study ... researchers at Cornell University knocked down the levels of ... the males abilities to modulate egg production, sperm storage ...
... Washington University School of Medicine in St. Louis have ... plague women with urinary tract infections (UTIs) are entrenched ... controversial revision of scientists, model of how bacteria cause ... for infections get into the bladder but do not ...
Cached Biology News:Final preparations for first human-rated spacecraft to be lauched from Europe's Spaceport 2Final preparations for first human-rated spacecraft to be lauched from Europe's Spaceport 3Bacteria that cause urinary tract infections invade bladder cells 2Bacteria that cause urinary tract infections invade bladder cells 3
(Date:7/14/2014)... , July 14, 2014 Cloud ... drug design and development, announced today the expansion ... company has been granted supercomputing time at Argonne ... targets.  Through a discretionary allocation ... Computing Facility (ALCF), researchers at Cloud Pharmaceuticals will ...
(Date:7/14/2014)... Canada (PRWEB) July 14, 2014 ... executives from across the clinical trials space, representing ... eCongress webinar series entitled “Optimizing Patient Participation in ... eCongress kicked off with internationally renowned R&D expert, ... Keynote address on Reinventing Drug Development through Patient ...
(Date:7/14/2014)... -- Minerva Neurosciences (NASDAQ: NERV ), a ... neuropsychiatric diseases and disorders, today announced that Frederick ... finance and chief accounting officer, effective June 2, 2014.  ... more than 20 years of experience in directing the ... background includes the management of compliance and reporting requirements ...
(Date:7/14/2014)... (PRWEB) July 14, 2014 ... registry platform, announced that three PatientCrossroads-based patient ... the Phelan-McDermid Syndrome International Registry; and the ... been awarded contracts by the Patient-Centered Outcomes ... creation of a new health data network ...
Breaking Biology Technology:Cloud Pharmaceuticals Granted 1M Hours of Supercomputer Time to Target Orphan Diseases Including Malaria 2Optimizing Patient Participation in Clinical Trials: Attract. Engage. Retain. – eCongress eBox Archives Now Available 2Optimizing Patient Participation in Clinical Trials: Attract. Engage. Retain. – eCongress eBox Archives Now Available 3Optimizing Patient Participation in Clinical Trials: Attract. Engage. Retain. – eCongress eBox Archives Now Available 4Optimizing Patient Participation in Clinical Trials: Attract. Engage. Retain. – eCongress eBox Archives Now Available 5Minerva Neurosciences Announces Appointment Of Frederick W. Ahlholm As VP Of Finance And Chief Accounting Officer 2PatientCrossroads Fuels Development of New National Clinical Research Network 2PatientCrossroads Fuels Development of New National Clinical Research Network 3
... , BEIJING, Sept. 16 ... hospital groups, has announced it will broaden inclusion,criteria ... study will use,stem cells derived from peripheral blood ... of diabetic foot ulcers involves intensive,wound management, risk ...
... 16 /PRNewswire-FirstCall/ - AEterna Zentaris Inc. (NASDAQ: ... company focused on endocrine therapy and oncology, today announced ... its partner and licensee for perifosine in the North ... from the U.S. Food and Drug Administration (FDA) for ...
... , , , SAN ... it is relaunching its oligonucleotide radiolabeling services. TriLink discontinued the ... that the market may no longer require it. However, strong ... in September 2009. , , "We,ve learned ...
Cached Biology Technology:Indian Stem Cell Trial to Broaden Diabetic Foot Inclusion Criteria 2Indian Stem Cell Trial to Broaden Diabetic Foot Inclusion Criteria 3Indian Stem Cell Trial to Broaden Diabetic Foot Inclusion Criteria 4AEterna Zentaris Partner, Keryx Biopharmaceuticals, Receives Orphan-Drug Designation for Perifosine (KRX-0401) for the Treatment of Multiple Myeloma 2AEterna Zentaris Partner, Keryx Biopharmaceuticals, Receives Orphan-Drug Designation for Perifosine (KRX-0401) for the Treatment of Multiple Myeloma 3TriLink BioTechnologies, Inc. Relaunches Oligonucleotide Radiolabeling Services 2
Mouse IL-31 RA Biotinylated Affinity Purified PAb...
... The steadylite plus assay ... High assay sensitivity, Designed for ... Suitable for higher density microplates ... plates, Odor free, Convenient storage ...
... versatile Promega Flipper® Racks are ideal for ... small tubes. These polypropylene racks withstand extreme ... freezer storage. They may also be autoclaved ... is two-sided; one side accommodates 0.5ml microcentrifuge ...
Sf9 cells derived from Spodoptera frugiperda ovarian cells (Sf21 cells) are commonly used to isolate and propagate recombinant AcMNPV viral stocks and to produce recombinant proteins....
Biology Products: