Navigation Links
Researchers demonstrate green tea is effective in treating genetic disorder and types of tumors
Date:8/15/2011

ST. LOUIS, MO, August 15, 2011A compound found in green tea shows great promise for the development of drugs to treat two types of tumors and a deadly congenital disease. The discovery is the result of research led by Principal Investigator, Dr. Thomas Smith at The Donald Danforth Plant Science Center and his colleagues at The Children's Hospital of Philadelphia. Their findings are published in the recent article, "Green Tea Polyphenols Control Dysregulated Glutamate Dehydrogenase In Transgenic Mice By Hijacking The ADP Activation Site" in The Journal of Biological Chemistry.

Glutamate dehydrogenase (GDH) is found in all living organisms and is responsible for the digestion of amino acids. In animals, GDH is controlled by a complex network of metabolites. For decades it was not clear why animals required such regulation but other kingdoms did not. This was partially answered by the Stanley group's finding that a deadly congenital disease, hyperinsulinism/hyperammonemia (HHS), is caused by the loss of some of this regulation. In this disorder, patients (typically children) respond to the consumption of protein by over secreting insulin, becoming severely hypoglycemic, often leading to death.

Using atomic structures to understand the differences between animals and plants, Dr. Smith and his colleagues discovered that two compounds found naturally in green tea are able to compensate for this genetic disorder by turning off GDH in isolated and when the green tea compounds were administered orally. The Smith lab also used X-ray crystallography to determine the atomic structure of these green tea compounds bound to the enzyme. With this atomic information, they hope to be able to modify these natural compounds to design and develop better drugs.

Interestingly, two other research groups have validated and extended these findings to demonstrate that blocking GDH with green tea is very effective at killing two different kinds of tumors; glioblastomas, an aggressive type of brain tumor, and tuberous sclerosis complex disorder, a genetic disease that causes non-malignant tumors to grow on a number of organs.

"While these compounds from green tea are extremely safe and consumed by millions every day, they have a number of properties that make them difficult to use as actual drugs. Nevertheless, our ongoing collaboration with the Stanley lab shows that there are natural compounds from plants that can control this deadly disorder and, with the atomic structure in hand, can be used as a starting point for further drug design."


'/>"/>

Contact: Melanie Bernds
mbernds@danforthcenter.org
314-587-1647
Donald Danforth Plant Science Center
Source:Eurekalert  

Related biology news :

1. Researchers discover freshwater mussel species thought to be extinct
2. NYU Langone researchers identify a signaling pathway as possible target for cancer treatment
3. Toronto researchers first to discover new genetic clue in the development of rheumatoid arthritis
4. Researchers decode workings of mysterious, but critical TB drug
5. Researchers fight cholera with computer forecasting
6. Vanderbilt researchers, international team, uncover genes linked to multiple sclerosis
7. Narcissism may benefit the young, researchers report; but older adults? Not so much
8. York U researchers zero in on protein that may help treat obesity, diabetes
9. Researchers use human cells to engineer functional anal sphincters in lab
10. Researchers use neutrons to spy on the elusive hydronium ion
11. UGA researchers study threats to white sturgeon
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Researchers demonstrate green tea is effective in treating genetic disorder and types of tumors
(Date:3/30/2017)... LOS ANGELES , March 30, 2017  On ... Hack the Genome hackathon at ... This exciting two-day competition will focus on developing health ... experience. Hack the Genome is ... has been tremendous. The world,s largest companies in the ...
(Date:3/28/2017)... 28, 2017 The report "Video ... Monitors, Servers, Storage Devices), Software (Video Analytics, VMS), and ... Global Forecast to 2022", published by MarketsandMarkets, the market ... is projected to reach USD 75.64 Billion by 2022, ... The base year considered for the study is 2016 ...
(Date:3/23/2017)... The report "Gesture Recognition and Touchless Sensing Market by ... Global Forecast to 2022", published by MarketsandMarkets, the market is expected to be ... 2017 and 2022. Continue Reading ... ... ...
Breaking Biology News(10 mins):
(Date:8/17/2017)... Village, CA (PRWEB) , ... August 17, 2017 ... ... technology for cancer research and personalized medicine, today announced the launch of a ... Kansas City, Missouri. The study’s goal is to evaluate the potential for early ...
(Date:8/16/2017)... ... August 16, 2017 , ... ... Electrospinning and Electrospraying line of nanofiber and nanoparticle fabrication ... for the lab to fully automated pilot plants and equipment for industrial ...
(Date:8/16/2017)... ... August 16, 2017 , ... While art and science are often ... connected than one might think. A Mesh Is Also a Snare, a group ... City Science Center’s Esther Klein Gallery (EKG) on August 17 and run through September ...
(Date:8/16/2017)... ... August 16, 2017 , ... We are proud ... (FDA) inspection at our Dilworth, MN site. The inspection took place Monday, July ... conducted as part of a routine Bioresearch Monitoring Program (BIMO) with the USFDA ...
Breaking Biology Technology: