Navigation Links
Researchers decipher the mecanism of membrane fission
Date:10/26/2012

A cell is composed of a nucleus which encloses its genetic information and the cytoplasm which is itself confined by an external membrane separating the cell from the outside world. The impermeability of the membrane and its ability to repair itself protect the cell from its environment. Although this membrane resistance is fundamental to the survival of the cell, the cell also needs to let in particles necessary for its proper functioning. The mechanism by which a small region of the cytoplasmic membrane invaginates to form a bud that will then be sectioned off to let molecules and other particles into the cell is known as endocytosis.

However, this natural process remains elusive due to the remarkable resistance of the cell membrane. Aurlien Roux, a professor of biochemistry and member of the National Centres of Competence in Research (NCCR) Chemical Biology, heads a team that focused on dynamin, a protein involved in endocytosis, to try to understand how an ultra-resistant membrane can nevertheless let external elements enter into the cell.

The power of dynamin

Scientists conducted in vitro experiments using artificial membrane tubules with a radius of 10 to 100 nanometres. They discovered that once dynamin is injected into the tube, it polymerises. In other words, it forms a helix around the tube and compresses it until it breaks. Dynamin produces the energy necessary for this constriction by consuming GTP molecules, much like a car consumes gasoline.

Based on these experiments, Professor Roux's team observed that the location of the fission is very specific and appears at the boundary between the helix and the membrane. A change in radius that curves the membrane, caused by the polymerisation of dynamin, induces a stress that promotes the fracture, states Sandrine Morlot, researcher at the Department of Biochemistry. This is new data allowing us to explain the process of fission.

The researchers were also able to measure the time it took to fission the membrane. Its duration depends on the mechanical properties of the membrane, which vary from one cell to another.

We found that the ability of dynamin to break an ultra-resistant membrane is due to its torque, that is to say, its rotational force, which is vastly superior to that of other proteins, explains Professor Roux. By decrypting the effect of dynamin on the membrane, we have come to understand the workings of membrane fission, a phenomenon which is certainly natural but remains extremely complex.


'/>"/>
Contact: Aurlien Roux
aurelien.roux@unige.ch
022-379-3532
Universit de Genve
Source:Eurekalert

Related biology news :

1. SDSU researchers to study Chinas national treasure
2. Exercise boosts satisfaction with life, researchers find
3. UC Davis researchers develop new drug delivery system for bladder cancer using nanoparticles
4. Far from random, evolution follows a predictable genetic pattern, Princeton researchers find
5. USF researchers identify gene mutation linked to old age hearing loss
6. USDA scientists collaborate with global researchers to advance the mapping of the barley genome
7. Danish researchers release ground-breaking knowledge about calcium pumps in cells
8. CU-Boulder researchers uncover new target for cancer research
9. Columbia researchers report novel approach for single molecule electronic DNA sequencing
10. Researchers develop new stamping process to pattern biomolecules at high resolution
11. Mount Sinai researchers awarded Provocative Questions grant from National Cancer Institute
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/2/2017)... March 2, 2017 Australian stem cell and ... CYP), has signed an agreement with the Monash Lung ... Biomedicine Discovery Institute and Department of Pharmacology at Monash ... further preclinical study to support the use of Cymerus™ ... Asthma is a chronic, long term ...
(Date:2/28/2017)... ANGELES , Feb. 28, 2017   Acuant ... verification software globally, announces significant enhancements to new and ... May 2016. New products include mobile and desktop Acuant ... DocX TM - a real time manual review ... core idScan® technology provides the fastest and most accurate ...
(Date:2/28/2017)... BARCELONA , Spanien, 27. Februar 2017 /PRNewswire/ ... durch Iris-Scan, wird seine erstklassige biometrische Lösung ... Snapdragon™ 835 mit X16 LTE auf dem ... 2. März) am Qualcomm-Stand in Halle 3, ... 835-Prozessor beinhaltet die Sicherheitsplattform Qualcomm Haven™ – ...
Breaking Biology News(10 mins):
(Date:3/23/2017)... ... 2017 , ... Ellen Matloff, president and CEO of My ... a 2017 Women of Innovation® finalist. Matloff will be among several women to ... dinner recognizes women accomplished in science, technology, engineering and math (STEM), along with ...
(Date:3/23/2017)... In today,s pre-market research, Stock-Callers.com ... Biotech industry: Sangamo Therapeutics Inc. (NASDAQ: SGMO), Eyegate Pharmaceuticals ... and Regulus Therapeutics Inc. (NASDAQ: RGLS ). ... its rating on Pharmaceuticals/Biotechnology to "Overweight" from "Market Weight." Learn more ... ...
(Date:3/22/2017)... MONICA, Calif. , March 22, 2017 /PRNewswire/ ... are proud to announce their extended partnership and ... will be headlined by the 21 st ... BIOMEDevice Boston, taking place May 3-4, 2017. ... Advanced Medical Technology Association (ADVAMED) President and CEO, ...
(Date:3/22/2017)... MarketNewsUpdates.com News Commentary  ... The traditional ways to ... as of late due to the rise of the opioid ... dramatic impact on patient,s quality of life as Biotech and ... new forms of opioid formulations that prevent abuse. Biotech and ...
Breaking Biology Technology: