Navigation Links
Researchers decipher the mecanism of membrane fission
Date:10/26/2012

A cell is composed of a nucleus which encloses its genetic information and the cytoplasm which is itself confined by an external membrane separating the cell from the outside world. The impermeability of the membrane and its ability to repair itself protect the cell from its environment. Although this membrane resistance is fundamental to the survival of the cell, the cell also needs to let in particles necessary for its proper functioning. The mechanism by which a small region of the cytoplasmic membrane invaginates to form a bud that will then be sectioned off to let molecules and other particles into the cell is known as endocytosis.

However, this natural process remains elusive due to the remarkable resistance of the cell membrane. Aurlien Roux, a professor of biochemistry and member of the National Centres of Competence in Research (NCCR) Chemical Biology, heads a team that focused on dynamin, a protein involved in endocytosis, to try to understand how an ultra-resistant membrane can nevertheless let external elements enter into the cell.

The power of dynamin

Scientists conducted in vitro experiments using artificial membrane tubules with a radius of 10 to 100 nanometres. They discovered that once dynamin is injected into the tube, it polymerises. In other words, it forms a helix around the tube and compresses it until it breaks. Dynamin produces the energy necessary for this constriction by consuming GTP molecules, much like a car consumes gasoline.

Based on these experiments, Professor Roux's team observed that the location of the fission is very specific and appears at the boundary between the helix and the membrane. A change in radius that curves the membrane, caused by the polymerisation of dynamin, induces a stress that promotes the fracture, states Sandrine Morlot, researcher at the Department of Biochemistry. This is new data allowing us to explain the process of fission.

The researchers were also able to measure the time it took to fission the membrane. Its duration depends on the mechanical properties of the membrane, which vary from one cell to another.

We found that the ability of dynamin to break an ultra-resistant membrane is due to its torque, that is to say, its rotational force, which is vastly superior to that of other proteins, explains Professor Roux. By decrypting the effect of dynamin on the membrane, we have come to understand the workings of membrane fission, a phenomenon which is certainly natural but remains extremely complex.


'/>"/>
Contact: Aurlien Roux
aurelien.roux@unige.ch
022-379-3532
Universit de Genve
Source:Eurekalert

Related biology news :

1. SDSU researchers to study Chinas national treasure
2. Exercise boosts satisfaction with life, researchers find
3. UC Davis researchers develop new drug delivery system for bladder cancer using nanoparticles
4. Far from random, evolution follows a predictable genetic pattern, Princeton researchers find
5. USF researchers identify gene mutation linked to old age hearing loss
6. USDA scientists collaborate with global researchers to advance the mapping of the barley genome
7. Danish researchers release ground-breaking knowledge about calcium pumps in cells
8. CU-Boulder researchers uncover new target for cancer research
9. Columbia researchers report novel approach for single molecule electronic DNA sequencing
10. Researchers develop new stamping process to pattern biomolecules at high resolution
11. Mount Sinai researchers awarded Provocative Questions grant from National Cancer Institute
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/11/2016)... , March 11, 2016 http://www.apimages.com ) ... Cross reference: Picture is available at AP Images ( http://www.apimages.com ) ... DERMALOG will be used to produce the new refugee identity cards. ... biometric innovations, at CeBIT in Hanover next ... from DERMALOG will be used to produce the new refugee identity ...
(Date:3/9/2016)... YORK , March 9, 2016 This ... and future states of the RNA Sequencing (RNA Seq) ... segments such as instruments, tools and reagents, data analysis, ... Analyze various segments of the RNA-Sequencing market such as ... services Identify the main factors affecting each segment and ...
(Date:3/3/2016)... MONTEREY, Calif. , March 3, 2016  FlexTech, ... in the categories of Innovation, Research & Development, Leadership ... Industry Leadership. This is the 9 th year ... select group of companies and individuals from past ... nominations based on a pre-described set of criteria, by ...
Breaking Biology News(10 mins):
(Date:5/3/2016)... ... May 03, 2016 , ... Flagship ... Dr. Nancy Gillett to its Board of Directors. Dr. Gillett recently retired from ... Executive Vice President and Chief Scientific Officer. A board-certified veterinary pathologist, Dr. Gillett ...
(Date:5/3/2016)...  Dr. Thomas P. McHugh , an internationally ... Woodlands, Texas , now offers SculpSure, the new ... cells in just 25-minutes, leaving a slimmer figure for ... Americans report feeling bothered by excess weight and are ... a growing industry. This innovative new approach to non-invasive ...
(Date:5/2/2016)... (PRWEB) , ... May 02, 2016 , ... ... with its clients in mind, the fresh look and added functionality give the ... “Recent years have seen a dynamic shift in agriculture – from precision farming ...
(Date:4/29/2016)... ... April 29, 2016 , ... ... medicine, is excited to announce the launch of the Proove Health Foundation ... volunteerism, and education to promote the use of personalized medicine for tackling the ...
Breaking Biology Technology: