Navigation Links
Researchers decipher modus operandi of potential Alzheimer's drug
Date:2/20/2013

tries to prevent harmful reactions with the help of antioxidants," says Eckhard Mandelkow. "However, with age and in cases of neurodegenerative diseases such as Alzheimer's, this protective system weakens allowing tau proteins to aggregate."

Beta sheets also important

Zweckstetter stresses that along with the disulfide bridges, another mechanism is important for the clumping of tau proteins. "Tau proteins aggregate particularly quickly when disulfide bonds form. These work like a trigger. However, tau proteins can also aggregate without these bridges, albeit more slowly."

This is due to the structure of the molecule, the backbone of which can fold like an accordion in some places. Such regions can pile up to "beta sheets" when two proteins come together closely enough and in the appropriate orientation. "Our experiments also show a distinct effect of methylene blue on the regions that want to form these beta sheets." Thus, methylene blue, particularly its derivatives "Azure A" and "Azure B", which are expected to be predominantly present in the body, also appear to inhibit the aggregation of beta sheets. "Steric hindrance occurs," Zweckstetter guesses. "When an inhibitor attaches to a beta sheet region of the tau protein, no other tau molecule can lock on."

There are other substances besides methylene blue that can suppress the aggregation of tau proteins. Some of them focus explicitly on preventing the build-up of beta sheets. The researchers believe that an effective treatment could ultimately require a combination of various substances: "Certainly, one conclusion of our study is that there are different ways to disrupt the pathogenic aggregation of tau proteins."


'/>"/>

Contact: Dirk Frger
presse@dzne.de
49-228-433-02260
Helmholtz Association of German Research Centres
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Stanford researchers develop tool for reading the minds of mice
2. Researchers in Manchester find genetic key to preventing spine tumors
3. When It Comes To Genetic Code, Researchers Prove Optimum Isnt Always Best
4. UTSW researchers identify new enzyme that acts as innate immunity sensor
5. Researchers make racehorses fertile
6. USC researchers find possible genetic clues to organ development, birth defects
7. Researchers discover Achilles heel for lymphoid leukemia
8. Researchers find Asian needle ants displacing other aggressive invaders
9. Spanish researchers design biomarkers for the detection of dengue and West Nile virus
10. UT Dallas researchers pushing the boundaries of virtual reality
11. Polar bear researchers urge governments to act now and save the species
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/22/2015)... DALLAS , May 22, 2015 ... Recognition Market by Solution (2D, 3D, Thermal, Emotion, Forensic), by ... End User (Government and Utilities, Consumer and Home) - ... Market to grow from $2.77 Billion in 2015 to ... Browse 79 market data Tables and ...
(Date:5/21/2015)... The Sync Project™ , a global collaboration harnessing ... a collaborative partnership with Berklee,s Institute for Creative ... on original research, joint course development and an internship ... Sync Project and BerkleeICE are exploring the launch of ... academic year.  The course will focus ...
(Date:5/20/2015)... 20, 2015 NXT-ID, Inc. (NASDAQ: NXTD ... owned subsidiary, 3D-ID LLC, a company engaged in biometric ... the biometrics technology portion of the recently awarded TIES ... Department of the Army. 3D-ID LLC has ... government, law enforcement and security agencies. ...
Breaking Biology News(10 mins):Facial Recognition Market Worth $6.19 Billion by 2020 2Facial Recognition Market Worth $6.19 Billion by 2020 3The Sync Project Announces Partnership with Berklee College of Music's Institute for Creative Entrepreneurship 2The Sync Project Announces Partnership with Berklee College of Music's Institute for Creative Entrepreneurship 3NXT-ID, Inc Announces Participation as Member of Team Battelle for TIES Contract Award 2NXT-ID, Inc Announces Participation as Member of Team Battelle for TIES Contract Award 3
... studying pigeons with genetic heart disease, researchers at Wake ... about why some patients' heart vessels are prone to ... a regulator of genes that controls the growth of ... researcher. "Learning to modulate the uncontrolled growth of these ...
... Northwestern University research group has discovered that aggressive ... critical to proper embryo formation. , An ... the advanced online issue of the journal Nature ... embryonic growth factor by injecting aggressive melanoma cells ...
... norepinephrine levels in the brains of rats to ... in the sensory pathways to make it easier ... team has found. , Their report in the ... aids people with attention deficit and hyperactivity disorders ...
Cached Biology News:Pigeons provide clue to solving common problem in heart patients 2Malignant melanoma cells secrete protein required for embryo formation 2Ritalin packs punch by elevating norepinephrine, suppressing nerve signal transmissions 2Ritalin packs punch by elevating norepinephrine, suppressing nerve signal transmissions 3
(Date:5/28/2015)... May 28, 2015 Natera, Inc., a ... study published in Ultrasound in Obstetrics & ... (SNP)-based non-invasive prenatal test (NIPT) can identify a ... A study based upon data collected ... occur in about 1 in 1,000 pregnancies, although ...
(Date:5/28/2015)... Mass. , May 28, 2015 RXi ... focused on discovering and developing innovative therapeutics, primarily in ... pricing of a public offering of 26 million units ... share for gross proceeds of approximately $10.4 million. Each ... (ii) a 13-month overallotment purchase right to purchase 0.50 ...
(Date:5/28/2015)... The Fertility Centers of New England is ... has taken on a new and expanded role as ... guidance, leadership, oversight and quality assurance for the practice. ... our team of experienced reproductive endocrinologists,” said Fertility Centers ... M.D. “Her expertise and compassionate, individualized care have helped ...
(Date:5/28/2015)... May 28, 2015 American Process ... (Oak Ridge, TN) recently signed a joint ... printing plastic resins using nanocellulose, a rapidly emerging ... 3D printing is the limited number of feedstock ... mechanical strength to printed parts for load bearing ...
Breaking Biology Technology:First Confirmed Detection of a Complete Molar Pregnancy with Cell-Free DNA Test 2First Confirmed Detection of a Complete Molar Pregnancy with Cell-Free DNA Test 3RXi Pharmaceuticals Announces $10 Million Public Offering of Common Stock and Warrants 2RXi Pharmaceuticals Announces $10 Million Public Offering of Common Stock and Warrants 3Danielle Vitiello, MD of Fertility Centers of New England, Named New Medical Director 2American Process Inc. Announces Partnership with Oak Ridge National Laboratory to Make 3D Printing Plastic Resins Stronger and More Sustainable 2American Process Inc. Announces Partnership with Oak Ridge National Laboratory to Make 3D Printing Plastic Resins Stronger and More Sustainable 3
... May 9, 2011 The U.S. Food and Drug Administration ... to the development of a user fee program for ... (Logo: http://photos.prnewswire.com/prnh/20090824/FDALOGO ) Biological products ... microorganism, plant, or animal cell, while small molecule drugs ...
... On May 17-18, 2011, Diversity Alliance for Science, ... and develop minority-, woman-, veteran/service-disabled-, HUBZone-, and LGBT-owned, ... networking conference and EXPO event.  The two-day event ... Hotel in Newark, N.J. and will feature senior ...
... SAN DIEGO, May 9, 2011 Ardea Biosciences, Inc. ... on the development of small-molecule therapeutics for the treatment ... results for the first quarter ended March 31, 2011. ... lesinurad in combination with allopurinol demonstrate lesinurad,s potential to ...
Cached Biology Technology:FDA Requests Input on Development of User Fee Program for Biosimilar and Interchangeable Biological Products 2Diversity Alliance for Science to Host Fourth Annual Networking Conference and Expo 2Diversity Alliance for Science to Host Fourth Annual Networking Conference and Expo 3Diversity Alliance for Science to Host Fourth Annual Networking Conference and Expo 4Ardea Biosciences Reports Recent Accomplishments and Announces First Quarter 2011 Financial Results 2Ardea Biosciences Reports Recent Accomplishments and Announces First Quarter 2011 Financial Results 3Ardea Biosciences Reports Recent Accomplishments and Announces First Quarter 2011 Financial Results 4Ardea Biosciences Reports Recent Accomplishments and Announces First Quarter 2011 Financial Results 5Ardea Biosciences Reports Recent Accomplishments and Announces First Quarter 2011 Financial Results 6
TGF-beta 1,-2,-3 MAb (Clone 1D11)...
HSV-1 gE Envelope Protein (9H3)...
... Stem cells are functionally defined by ... ability to differentiate into multiple specialized progenitor ... along specific lineages. Neural stem cells (NSCs) ... types including astrocytes, neurons and oligodendrocytes. During ...
Lineage cocktail 1 (lin 1) 50 tests...
Biology Products: