Navigation Links
Researchers decipher modus operandi of potential Alzheimer's drug
Date:2/20/2013

tries to prevent harmful reactions with the help of antioxidants," says Eckhard Mandelkow. "However, with age and in cases of neurodegenerative diseases such as Alzheimer's, this protective system weakens allowing tau proteins to aggregate."

Beta sheets also important

Zweckstetter stresses that along with the disulfide bridges, another mechanism is important for the clumping of tau proteins. "Tau proteins aggregate particularly quickly when disulfide bonds form. These work like a trigger. However, tau proteins can also aggregate without these bridges, albeit more slowly."

This is due to the structure of the molecule, the backbone of which can fold like an accordion in some places. Such regions can pile up to "beta sheets" when two proteins come together closely enough and in the appropriate orientation. "Our experiments also show a distinct effect of methylene blue on the regions that want to form these beta sheets." Thus, methylene blue, particularly its derivatives "Azure A" and "Azure B", which are expected to be predominantly present in the body, also appear to inhibit the aggregation of beta sheets. "Steric hindrance occurs," Zweckstetter guesses. "When an inhibitor attaches to a beta sheet region of the tau protein, no other tau molecule can lock on."

There are other substances besides methylene blue that can suppress the aggregation of tau proteins. Some of them focus explicitly on preventing the build-up of beta sheets. The researchers believe that an effective treatment could ultimately require a combination of various substances: "Certainly, one conclusion of our study is that there are different ways to disrupt the pathogenic aggregation of tau proteins."


'/>"/>

Contact: Dirk Frger
presse@dzne.de
49-228-433-02260
Helmholtz Association of German Research Centres
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Stanford researchers develop tool for reading the minds of mice
2. Researchers in Manchester find genetic key to preventing spine tumors
3. When It Comes To Genetic Code, Researchers Prove Optimum Isnt Always Best
4. UTSW researchers identify new enzyme that acts as innate immunity sensor
5. Researchers make racehorses fertile
6. USC researchers find possible genetic clues to organ development, birth defects
7. Researchers discover Achilles heel for lymphoid leukemia
8. Researchers find Asian needle ants displacing other aggressive invaders
9. Spanish researchers design biomarkers for the detection of dengue and West Nile virus
10. UT Dallas researchers pushing the boundaries of virtual reality
11. Polar bear researchers urge governments to act now and save the species
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/28/2014)... the developmental on-off switch for Streptomyces , a ... of the world,s naturally derived antibiotic medicines. , ... is possible to manipulate this switch to make nature,s ... August 28 in Cell , found that a ... a larger protein called BldD ultimately controls whether a ...
(Date:8/28/2014)... Aug. 28, 2014A new method for measuring and imaging ... doctors and researchers better understand how drug abuse affects ... and tissue engineering, and lead to better treatment options ... a team of researchers from Stony Brook University in ... Health, was published today in The Optical Society,s (OSA) ...
(Date:8/28/2014)... the first person to alert the world to Global ... be captured and stored underground. He says that Carbon ... the best way to avoid global warming getting out ... (Columbia University, New York) made the call during his ... where 150 scientists are meeting to discuss Carbon Capture ...
Breaking Biology News(10 mins):Small molecule acts as on-off switch for nature's antibiotic factory 2Small molecule acts as on-off switch for nature's antibiotic factory 3This is your brain's blood vessels on drugs 2This is your brain's blood vessels on drugs 3Global warming pioneer calls for CO2 to be taken from atmosphere and stored underground 2
... type of immune cell DNA in the blood could ... transplant will successfully restore a population of infection-fighting cells ... investigators at St. Jude Children's Research Hospital, is published ... physicians predict whether children receiving such a transplant will ...
... dinosaurs died and became fossilized, soft tissues didn't ... through a gradual replacement of all organic material ... State University paleontologist, however, could literally turn that ... professor of paleontology with a joint appointment at ...
... by Johns Hopkins scientists has,found the first clear ... remarkable ability to recognize and respond to a ... of genes whose,only apparent function is to jump ... themselves out of the genetic material, and scientists,have ...
Cached Biology News:Circles Of DNA Might Help Predict Success Of Stem Cell Transplantation 2Circles Of DNA Might Help Predict Success Of Stem Cell Transplantation 3Circles Of DNA Might Help Predict Success Of Stem Cell Transplantation 4NC State scientist finds soft tissue in T. rex bones 2New therapy for HIV/AIDS eliminates needles and excessive toxicity 2New therapy for HIV/AIDS eliminates needles and excessive toxicity 3
(Date:8/28/2014)...  Next month, executives from clinical trial marketing firm BBK ... with Patient-Centered Clinical Trials 2014 , to be held ... , September 4-5. Patient recruitment experts Bonnie A. Brescia ... will share insights on the benefits of employing an effective ... from media to mobile apps – can be used to ...
(Date:8/28/2014)... , Aug. 28, 2014  Armetheon, Inc. ... developing novel mid- to late-stage cardiovascular drug candidates, ... in its first round of financing. The Series ... and Hercules Bioventures with participation from investors that ... pharmaceutical executive, Dr. Larry Hsu , the ...
(Date:8/28/2014)... Woodstock, Vt. (PRWEB) August 28, 2014 ... microbiology testing around the world is available from ... industrial diagnostics companies. “ Industrial Microbiology Market Review, ... the Industrial Market ” (IMMR—4) tracks and compares ... in in North America, Europe and Asia, and ...
(Date:8/28/2014)... (PRWEB) August 28, 2014 Supplementing ... offering a promotion for Eppendorf Safe Lock ... to purchase the highest quality tubes at an ... ideal for customers doing chemical, medical, pharmaceutical, and ... who are not regularly able to afford Eppendorf ...
Breaking Biology Technology:BBK Worldwide Leads Sessions at Key September Events 2Armetheon Completes $7.0 Million Series A Financing 2Armetheon Completes $7.0 Million Series A Financing 32 Billion Industrial Microbiology Tests Conducted for Product Quality and Safety Worldwide 22 Billion Industrial Microbiology Tests Conducted for Product Quality and Safety Worldwide 3Eppendorf Safe Lock Centrifuge Tube Promotion Now Available at Major Pipette Distributor Pipette.com 2Eppendorf Safe Lock Centrifuge Tube Promotion Now Available at Major Pipette Distributor Pipette.com 3
... FRAZER, Pa. and MAISONS-ALFORT, France, April 14 /PRNewswire-FirstCall/,-- ... that the European,Commission has granted marketing authorization for ... indicated for the treatment of,breakthrough cancer pain (BTCP) ... therapy for chronic pain. The approval allows Cephalon,to ...
... Biomarkers form basis of blood-based ColonSentry(TM) test -, ... (TSX: GEN),a company focused on developing blood-based biomarker ... health management, today reported,positive performance results from a ... the assessment of a patient,s current risk for,colorectal ...
... April 11 ImaRx Therapeutics,Inc. (Nasdaq: IMRX ) ... on April 11, 2008 indicating that for the last ... stock has closed,below $1.00 per share. As a result, ... requirement for continued listing set forth in,Marketplace Rule 4310(c)(4)., ...
Cached Biology Technology:Cephalon Announces European Commission Approval of EFFENTORA for the Treatment of Breakthrough Cancer Pain 2Cephalon Announces European Commission Approval of EFFENTORA for the Treatment of Breakthrough Cancer Pain 3Cephalon Announces European Commission Approval of EFFENTORA for the Treatment of Breakthrough Cancer Pain 4GeneNews reports positive results from validation study of colorectal cancer biomarkers in late-breaking abstract at AACR 2GeneNews reports positive results from validation study of colorectal cancer biomarkers in late-breaking abstract at AACR 3ImaRx Therapeutics Receives Notification from NASDAQ Regarding Non-Compliance with NASDAQ's Minimum Bid Price Requirement 2
, Premium quality synthesis and purification , You provide the sequence, we'll do the rest , Rigorous quality control , Your choice of purification method, amount and format , Available annealed...
... Synthetic peptide derived from an internal region ... target of rapamycin FRAP RAFT1 RAPT1). ... On Western blots it identifies the ... Human (positive control: HEK293 cell lysates). Based ...
...
From micro to giga sizes, from single prep to high-throughput, Invitrogen's range of plasmid purification kits offers superior performance to match the demands of your downstream application....
Biology Products: