Navigation Links
Researchers create safer alternative to heparin
Date:8/17/2008

Troy, N.Y. Robert Linhardt has spent years stitching together minuscule carbohydrates to build a more pure and safer alternative to the commonly used and controversial blood thinner heparin. At the national conference of the American Chemical Society on August 17, 2008, Linhardt announced that his research team may have accomplished this task by building the first fully synthetic heparin. Their creation is the largest dose of heparin ever created in the lab.

Heparin is used around the globe and is among the most widely used drugs in American hospitals. The main source of this heparin is the intestines of foreign livestock and the risk of contamination from such sources is high, according to Linhardt. And as Linhardt and others around the globe worked toward an alternative, drug manufacturers worked to avoid contamination, but the risks proved too high, Linhardt said. In the spring of 2008, the search for a safer alternative to the common drug had reached a frantic pace after more than 80 people around the world died and hundreds became ill after they were administered what was believed to be contaminated batches of heparin.

Linhardt, who is the Ann and John H. Broadbent Jr. '59 Senior Constellation Professor of Biocatalysis and Metabolic Engineering at Rensselaer Polytechnic Institute, was on the international team that identified the suspected contaminant in the Chinese heparin, a structurally similar carbohydrate called oversulfated chondroitin sulfate.

"When we found the contamination, it was another sign that the way we currently manufacture heparin is simply unsafe," he said. "Unlike the current heparin that is harvested from possibly disease carrying animals in often very poor conditions, our fully synthetic heparin will be created in a pharmaceutical manufacturing environment from fermentation to packaging. This will give drug manufacturers extreme control over the safety and purity of the product."

Linhardt, toget
'/>"/>

Contact: Jason Gorss
gorssj@rpi.edu
518-276-6098
Rensselaer Polytechnic Institute
Source:Eurekalert

Page: 1 2

Related biology news :

1. Researchers identify proteins involved in new neurodegenerative syndrome
2. Texas researchers and educators head for Antarctica
3. MGH researchers describe new way to identify, evolve novel enzymes
4. University of Pennsylvania researchers develop formula to gauge risk of disease clusters
5. U of MN researchers discover noninvasive diagnostic tool for brain diseases
6. U of Minnesota researchers discover noninvasive diagnostic tool for brain diseases
7. Researchers discover new strategies for antibiotic resistance
8. Researchers find new taste in fruit flies: carbonated water
9. Binghamton University researchers investigate evolving malaria resistance
10. UIC researchers find promising new targets for antibiotics
11. Researchers develop simple method to create natural drug products
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/25/2014)... people lived on the land now called California, and ... availability of plants they used for food, fuel, tools, ... maintain desired habitat and natural resources. , Frank Lake, ... Station, will lead a field trip to ... Society of America,s 99th Annual Meeting, in Sacramento, Cal. ...
(Date:7/25/2014)... 2014)The link between autism and disrupted brain development ... the disease, and is largely unknown. However, thanks ... Initiative (SFARI), George Washington University (GW) researcher Anthony-Samuel ... integrative and in-depth answers to these key questions ... LaMantia, professor of pharmacology and physiology at the ...
(Date:7/25/2014)... engineering at the University of Houston, has written ... organ development., "Introduction to Tissue Engineering: Applications and ... the field of artificial organ development. Metin Akay, ... UH, served as a series editor on the ... published books on the subject of growing artificial ...
Breaking Biology News(10 mins):Fire ecology manipulation by California native cultures 2Fire ecology manipulation by California native cultures 3GW researcher receives grant to answer the how and why of autism during development 2University of Houston researcher publishes textbook on tissue engineering 2
... cells called macrophages can destroy tumor cells by producing ... the environment inside the tumor somehow halts this production ... promote tumor growth. The new study ... switch. This protein normally stimulates protective inflammation. But in ...
... ability every aging Hollywood star would envy: they can ... the May 19 issue of the Journal of ... London, UK) and collogues have pinned down a protein ... that might help researchers understand why myelin production falters ...
... Fla. (May 19, 2008) The current issue of ... by researchers seeking new ways to treat Parkinsons disease ... and slowed physical movements related to insufficient levels of ... by using primate models to examine the potential therapy ...
Cached Biology News:Neural cell transplants may help those with Parkinson's disease 2Neural cell transplants may help those with Parkinson's disease 3
(Date:7/24/2014)... leader Yung-Eun Sung has announced that they have ... graphenes which can be applied as high performance ... Sung is both a group leader at the ... Science* (IBS) and a professor at the Seoul ... with regards to the development of relative simplicity, ...
(Date:7/24/2014)... and synthetic processes prefer to settle into equilibriuma ... is within the realm of non-equilibrium conditions where ... in energy and phases, such as temperature fluctuations, ... humans to regulate their body temperature, airplanes to ... activity. , But even though these conditions ...
(Date:7/24/2014)... California (PRWEB) July 24, 2014 ... to advances in modeling lithium-ion battery storage capacity. ... benefit from a theoretical model created at ... University that predicts how carbon components will ... energy storage emphasizes the urgent need for higher-performance ...
(Date:7/24/2014)... Three companies from the angelMD network ... C Competition. Out of 700 competition entrants, Chiron Health, ... semi-final round. In this round twenty teams are invited ... with mentoring from thought-leaders and medical entrepreneurs from all ... angelMD commitment to the Livestrong vision around the Big ...
Breaking Biology Technology:New approach to form non-equilibrium structures 2Getting More Life out of Lithium-ion Batteries 23 angelMD Startups Make Livestrong Big C Semi-finals 2
... RADI Medical Systems today,announced improvements to their ... which will begin shipments immediately., (Photo: ... generation of the PressureWire(R) Certus features a ... key,advantages for physicians. The new large entry ...
... /Xinhua-PRNewswire-FirstCall/ -- China-Biotics,Inc. (OTC Bulletin Board: CHBT) ... in the manufacture, research, development,marketing and distribution ... China-Biotics, Chief Technology Officer, has been invited ... Annual Food Safety Technology Forum,2008 (the "Forum")., ...
... Milestones and Maintain ... Commitment to Strategy, ... Inc.,(TSX: MGI, OTC: MGIFF), a clinical-stage developer of drugs for ... shareholders,for the purpose of acquiring control of MIGENIX,s board of ...
Cached Biology Technology:RADI Medical Systems Launches Next Generation PressureWire(R) Certus 2China-Biotics, Inc. to Present at China's 3rd Annual Food Safety Technology Forum 2008 2China-Biotics, Inc. to Present at China's 3rd Annual Food Safety Technology Forum 2008 3MIGENIX Corporate Update and Requisition of Special Meeting 2MIGENIX Corporate Update and Requisition of Special Meeting 3MIGENIX Corporate Update and Requisition of Special Meeting 4MIGENIX Corporate Update and Requisition of Special Meeting 5MIGENIX Corporate Update and Requisition of Special Meeting 6MIGENIX Corporate Update and Requisition of Special Meeting 7MIGENIX Corporate Update and Requisition of Special Meeting 8
... Todays research and biologic production demands ... guesswork to confirming viable cell populations. Therefore, ... cells must be determined accurately and precisely. ... an automatic and cost effective means to ...
... SureLINK Bioconjugation Kit provides a powerful yet ... and nuceleic acids. The kit provides the ... reagents for quantifying conjugation efficiencies. It enables ... biotin and other tags with a variety ...
... the sensitivity and versatility you expect from ... counting with selected photomultipliers ensure superior sensitivity ... with up to 2 reagent injectors the ... assays as well as other luminescence applications ...
Cell Culture Flask, 25 cm, tissue-culture treated polystyrene...
Biology Products: