Navigation Links
Researchers create map of 'shortcuts' between all human genes
Date:3/18/2013

es are located at a short biological distance from TLR3. As a result, novel herpes simplex encephalitis-causing genes are also expected to have a short biological distance from TLR3.

To test how well the human gene connectome could predict a disease-causing gene, the researchers sequenced exomes all DNA of the genome that is coding for proteins of two patients recently shown to carry mutations of a separate gene, TBK1.

"Each patient's exome contained hundreds of genes with potentially morbid mutations," says Itan. "The challenge was to detect the single disease-causing gene." After sorting the genes by their predicted biological proximity to TLR3, Itan and his colleagues found TBK1 at the top of the list of genes in both patients. The researchers also used the TLR3 connectome the set of all human genes sorted by their predicted distance from TLR3 to successfully predict two other genes, EFGR and SRC, as part of the TLR3 pathway before they were experimentally validated, and applied other gene connectomes to detect Ehlers-Danlos syndrome and sensorineural hearing loss disease causing genes.

"The human gene connectome is, to the best of our knowledge, the only currently available prediction of the specific route and distance between any two human genes of interest, making it ideal to solve the needle in the haystack problem of detecting the single disease causing gene in a large set of potentially fatal genes," says Itan. "This can now be performed by prioritizing any number of genes by their biological distance from genes that are already known to cause the disease.

"Approaches based on the human gene connectome have the potential to significantly increase the discovery of disease-causing genes for diseases that are genetically understood in some patients as well as for those that are not well studied. The human gene connectome should also progress the general field of human genetics by predicting the nature of unknown gene
'/>"/>

Contact: Joseph Bonner
joseph.bonner@rockefeller.edu
212-327-8998
Rockefeller University
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Study by UC Santa Barbara researchers suggests that bacteria communicate by touch
2. UC Santa Barbara researchers discover genetic link between visual pathways of hydras and humans
3. Researchers attempt to solve problems of antibiotic resistance and bee deaths in one
4. UNH researchers find African farmers need better climate change data to improve farming practices
5. Ottawa researchers to lead world-first clinical trial of stem cell therapy for septic shock
6. Researchers uncover molecular pathway through which common yeast becomes fungal pathogen
7. Researchers print live cells with a standard inkjet printer
8. Columbia Engineering and Penn researchers increase speed of single-molecule measurements
9. Researchers reveal how a single gene mutation leads to uncontrolled obesity
10. Researchers discover novel therapy for Crohns disease
11. New paper by Notre Dame researchers describes method for cleaning up nuclear waste
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/15/2014)... assess the pandemic risk from strains of influenza virus ... allow ourselves to become complacent that the most substantial ... scientists. , Influenza pandemics arise when a new virus ... widespread immunity – spreads in the human population. There ... years, the worst of which – the 1918 Spanish ...
(Date:10/15/2014)... an unexpected extent. The outbreak does not follow the ... a new disease dynamic in regions, where it has ... National Academy of Sciences Leopoldina, acatech – the German ... the German Academies of Sciences and Humanities have presented ... the statement the academies call for the following consequences ...
(Date:10/15/2014)... Fred Alt will be awarded the 44th Rosenstiel Award ... for his pioneering research exploring the mechanisms of genomic ... cancer cells. Alt is the second alumnus to win ... Nobel Prize in 2003. , Alt is the Charles ... at Harvard Medical School and an investigator at the ...
Breaking Biology News(10 mins):Scientists 'must not become complacent' when assessing pandemic threat from flu viruses 2Academies call for consequences from the Ebola virus epidemic 2Academies call for consequences from the Ebola virus epidemic 3Academies call for consequences from the Ebola virus epidemic 4Academies call for consequences from the Ebola virus epidemic 5Brandeis awards 44th Rosenstiel Award to pioneering geneticist Fred Alt 2
... way to activate Epstein-Barr viruses inside tumors as ... be manipulated to destroy their tumors. They say this ... cancers associated with Epstein-Barr, including at least four different ... In the March 1 issue of Clinical Cancer Research, ...
... intake can increase health and longevity. Professor Stephen Spindler ... reducing calorie intake later in life can still induce ... calorie reduction. Importantly, this also includes anti-cancer effects. , ... novel screening technique to find drugs which mimic this ...
... energy sources heats up, researchers at the University of ... responsible for biomass breakdown are turned on in a ... and cornstalks. , Waste products such as grass clippings ... ethanol—may soon be fodder for hungry, gene-tweaked bacteria. The ...
Cached Biology News:Researchers wake up viruses inside tumors to image and then destroy cancers 2Researchers wake up viruses inside tumors to image and then destroy cancers 3It's never too late to get it back! Aging interrupted 2Genome sequencing reveals key to viable ethanol production 2Genome sequencing reveals key to viable ethanol production 3
(Date:10/19/2014)... 19, 2014 The Latin American hardware ... in Latin America with analysis and forecast of revenue. ... and is expected to reach $2,366.8 million by 2018, ... , Browse through the TOC of the Latin American ... the in-depth analysis provided. It also provides a glimpse ...
(Date:10/19/2014)... The Asia-Pacific Bromine Market report ... with analysis and forecast of revenue. , Browse ... Market report, to get an idea of the ... of the segmentation in the Asia-Pacific bromine market, ... , http://www.micromarketmonitor.com/market/asia-pacific-bromine-6741503144.html , Bromine is ...
(Date:10/19/2014)... The report "Chocolate, Cocoa Beans, Lecithin, Sugar and ... and Forecast (2011 - 2016)," analyzes the chocolate ... the major market drivers, restraints, and opportunities for the ... The global chocolate market is expected to grow from ... an estimated CAGR of 2.7% from 2011 to 2016. ...
(Date:10/19/2014)... According to market research report “Outdoor ... Wireless gateways)]- Global Advancements, Forecasts and Analysis (2013 ... Wi-Fi market with analysis and forecasting of the ... the drivers and the restrains for this market ... challenges. , Browse 65 market data tables and ...
Breaking Biology Technology:The Latin American hardware encryption display market is expected to reach $2,366.8 million by 2018 - New Report by MicroMarket Monitor 2The Latin American hardware encryption display market is expected to reach $2,366.8 million by 2018 - New Report by MicroMarket Monitor 3The Asia-Pacific Bromine Market is estimated to grow to $4,080.1 million by 2018 - New Report by MicroMarket Monitor 2The Asia-Pacific Bromine Market is estimated to grow to $4,080.1 million by 2018 - New Report by MicroMarket Monitor 3Chocolate Market Projected To Reach $98.3 Billion by 2016 - New Report by MarketsandMarkets 2Chocolate Market Projected To Reach $98.3 Billion by 2016 - New Report by MarketsandMarkets 3Chocolate Market Projected To Reach $98.3 Billion by 2016 - New Report by MarketsandMarkets 4Outdoor Wi-Fi Market (by Access Points, WLAN Controllers, Wireless gateways) Expected to Cross $37.2 Billion by 2018 - New Report by MarketsandMarkets 2Outdoor Wi-Fi Market (by Access Points, WLAN Controllers, Wireless gateways) Expected to Cross $37.2 Billion by 2018 - New Report by MarketsandMarkets 3Outdoor Wi-Fi Market (by Access Points, WLAN Controllers, Wireless gateways) Expected to Cross $37.2 Billion by 2018 - New Report by MarketsandMarkets 4
... Quest Product Development, with partner,University of Colorado, ... Transfer grant by the National Institutes of ... next-generation endoscope. MicroFlex,technology, derived from aerospace engineering, ... active control over the shape of the ...
... Aug. 7 Odyssey Thera, Inc. announced,that it ... following,Pfizer,s decision to progress a discovery stage drug ... studied by,Odyssey Thera as part of the ongoing ... with the progress of the collaboration with,Pfizer," said ...
... /Xinhua-PRNewswire-FirstCall/ -- China-Biotics,Inc. (OTC Bulletin Board: CHBT), a ... marketing and distribution of,probiotics dietary supplements, today announced ... EDT on Friday, August 15, 2008, to discuss ... June 30, 2008, of its fiscal,2009., Hosting ...
Cached Biology Technology:NIH Funds $1M Research at Quest Product Development and University of Colorado for New Digitally-Controlled Endoscopes 2China-Biotics, Inc. Announces Conference Call to Discuss First Quarter 2009 Financial Results 2China-Biotics, Inc. Announces Conference Call to Discuss First Quarter 2009 Financial Results 3
...
... Collect XL provides RS232/Serial data collection ... Excel. Complete instrument integration with ... interfaces for balances, pH meters, titrators, density ... New RS232 and serial instruments can be ...
DNA sequencing - plasmids or PCR fragments, 3-7 working days service....
Nuclear/Cytosol Fractionation Kit Research Focus: other Storage Temperature: 4C Shipping Temperature: 4C...
Biology Products: