Navigation Links
Researchers create map of 'shortcuts' between all human genes
Date:3/18/2013

Some diseases are caused by single gene mutations. Current techniques for identifying the disease-causing gene in a patient produce hundreds of potential gene candidates, making it difficult for scientists to pinpoint the single causative gene. Now, a team of researchers led by Rockefeller University scientists have created a map of gene "shortcuts" to simplify the hunt for disease-causing genes.

The investigation, spearheaded by Yuval Itan, a postdoctoral fellow in the St. Giles Laboratory of Human Genetics of Infectious Diseases, has led to the creation of what he calls the human gene connectome, the full set of distances, routes (the genes on the way), and degrees of separation, between any two human genes. Itan, a computational biologist, says the computer program he developed to generate the connectome uses the same principles that GPS navigation devices use to plan a trip between two locations. The research is reported in the online early edition of the journal Proceedings of the National Academy of Sciences.

"High throughput genome sequencing technologies generate a plethora of data, which can take months to search through," says Itan. "We believe the human gene connectome will provide a shortcut in the search for disease-causing mutations in monogenic diseases."

Itan and his colleagues, including researchers from the Necker Hospital for Sick Children, the Pasteur Institute in Paris, and Ben-Gurion University in Israel, designed applications for the use of the human gene connectome. They began with a gene called TLR3, which is important for resistance to herpes simplex encephalitis, a life-threatening infection from the herpes virus that can cause significant brain damage in genetically susceptible children. Researchers in the St. Giles lab, headed by Jean-Laurent Casanova, previously showed that children with HSE have mutations in TLR3 or in genes that are closely functionally related to TLR3. In other words, these gen
'/>"/>

Contact: Joseph Bonner
joseph.bonner@rockefeller.edu
212-327-8998
Rockefeller University
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Study by UC Santa Barbara researchers suggests that bacteria communicate by touch
2. UC Santa Barbara researchers discover genetic link between visual pathways of hydras and humans
3. Researchers attempt to solve problems of antibiotic resistance and bee deaths in one
4. UNH researchers find African farmers need better climate change data to improve farming practices
5. Ottawa researchers to lead world-first clinical trial of stem cell therapy for septic shock
6. Researchers uncover molecular pathway through which common yeast becomes fungal pathogen
7. Researchers print live cells with a standard inkjet printer
8. Columbia Engineering and Penn researchers increase speed of single-molecule measurements
9. Researchers reveal how a single gene mutation leads to uncontrolled obesity
10. Researchers discover novel therapy for Crohns disease
11. New paper by Notre Dame researchers describes method for cleaning up nuclear waste
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/30/2014)... suite of perilous threats in today,s ocean. From ... change, fragile coral ecosystems are disappearing at unprecedented ... species of corals surrounding the island of Moorea ... their tropical environment: coral guard-crabs. New research from ... Station scientist Seabird McKeon and the museum,s predoctoral ...
(Date:9/29/2014)... gut bacteria called Clostridium ramosum , coupled with a ... is published this week in mBio , the online ... A research team from the German Institute of Human Nutrition ... including C. ramosum gained weight when fed a ... were less obese even when consuming a high-fat diet, ...
(Date:9/29/2014)... September 29: Between 1970 and 2010 populations of ... globe dropped 52 percent, says the 2014 Living ... (WWF). This biodiversity loss occurs disproportionately in low-income ... high-income countries. , In addition to the precipitous ... to other warning signs about the overall health ...
Breaking Biology News(10 mins):Smithsonian scientists discover coral's best defender against an army of sea stars 2Gut bacteria promote obesity in mice 2Half of global wildlife lost, says new WWF report 2
... This release is available in Spanish . ... emerald ash borer could mean improved traps for monitoring and ... of Agriculture (USDA) entomologist Allard Coss and his colleagues. ... part of a multidisciplinary team of scientists from USDA,s Agricultural ...
... WASHINGTON, April 7, 2011 Moms-to-be long have been ... staying fit during pregnancy is good for both mother and ... that exercising strengthens a fetus, heart control, many pregnant women ... up for prenatal yoga classes; others found new ways to ...
... WASHINGTON, April 7, 2011 Timing is everything. That,s ... created by the pancreas to break down food. When the ... reach the gut, where they get to work releasing and ... is wrong and the enzymes are activated too soon, they ...
Cached Biology News:Scientists exploit ash tree pest's chemical communication 2Physically active moms-to-be give babies a head start on heart health 2Physically active moms-to-be give babies a head start on heart health 3Findings may help keep pancreatic disease off the menu 2
(Date:10/1/2014)... Oct. 1, 2014  Discovery Laboratories, Inc. (Nasdaq: ... awarded a Phase II Small Business Innovation Research ... from the National Institute of Allergy and Infectious ... (NIH) to support the development of the Company,s ... countermeasure to mitigate acute and chronic/late-phase radiation-induced lung ...
(Date:10/1/2014)... As the world takes its first steps ... that this century would mark the beginning of a new ... science. The fact that the world is experiencing a rapid ... scientific community. Almost half of these chronic conditions are due ... with medical care and intervention. While the world is experiencing ...
(Date:10/1/2014)... 2014 Award winning unified communications ... four new-hosted collaboration bundles that combine next generation ... conferencing experiences for low, flat rate fees. ... businesses have optimized solutions to meet their technology ... audio only minutes (1K, 5K, 10K increments) or ...
(Date:10/1/2014)... PHILADELPHIA , October 1, 2014 ... plans to software invited to engage around the theme, ... 29-30     Elsevier ... information products and services, will host a gathering of ... discuss issues and trends impacting healthcare today and in ...
Breaking Biology Technology:Discovery Labs Receives SBIR Grant Valued up to $3.0 Million to Support Development of Aerosolized KL4 Surfactant to Address Radiation-Induced Lung Injury 2Discovery Labs Receives SBIR Grant Valued up to $3.0 Million to Support Development of Aerosolized KL4 Surfactant to Address Radiation-Induced Lung Injury 3Fighting Mortality and Morbidity of Chronic Health Disorders during Open Access Week 2Fighting Mortality and Morbidity of Chronic Health Disorders during Open Access Week 3SoundConnect Launches New Audio, Web and Video Bundles 2Elsevier Healthcare and Pharmaceutical Economics Conference 2014 To Convene Industry Leaders to Discuss Top Healthcare Business Issues 2Elsevier Healthcare and Pharmaceutical Economics Conference 2014 To Convene Industry Leaders to Discuss Top Healthcare Business Issues 3
... Feb. 21 Keryx Biopharmaceuticals,Inc. (Nasdaq: KERX ) ... at 8:30 a.m. EST to discuss the fourth quarter ... Michael S. Weiss, Chairman,and Chief Executive Officer of the ... results for this period in a press release to ...
... 13, 2008 at 9:00 am (Eastern) ... am (Pacific) / 9:00 pm (Beijing/Hong Kong), SHANGHAI, ... WX ) ("WuXi PharmaTech" or "the Company"), the ... announced that it will release unaudited,financial results for the ...
... 5% annually over the next five ... to Millennium Research Group, WALTHAM, Mass., Feb. 21 ... the US market for,fixed C-arm systems, comprising units used for ... in 2007 and will,rise to over $1.8 billion by 2012., ...
Cached Biology Technology:Keryx Biopharmaceuticals, Inc. to Hold Conference Call on Fourth Quarter and Year-End 2007 Financial Results on Monday, February 25, at 8:30 A.M. EST 2WuXi PharmaTech Schedules Fourth Quarter and Full Year 2007 Earnings Release on Wednesday, March 12, 2008 2Fixed C-Arms Revolutionize Operating Room Environments 2
... Background Cloning Kit includes the pZErO-1 vector ... coli. The pZErO-1 vector utilizes positive selection ... of the Zeocin resistance gene reduces the ... transformation efficiencies. The kit contains all of ...
NATIVE, ENZYME PORCINE TRYPSIN...
... S-Adenosyl-Homocysteine. S-Adenosyl Homocysteine 100%,S-Adenosyl Methionine ... 0.27%,Homocysteine ... <0.1%,L-Cysteine ... Assay Range: 0.1 ug/ml to ...
... Panomer 9 oligodeoxynucleotides ... are labeled at the ... proprietary Alexa Fluor dyes ... for assessing microarray spot ...
Biology Products: