Navigation Links
Researchers correct the record about behavior of important human protein tied to cancer
Date:1/25/2010

In a study to be published this week, a research team is challenging a prevailing belief about the behavior of a human protein linked to the formation of cancer, possibly breathing new life into the search for therapies that will inhibit that protein from "turning on" genes involved in abnormal cell proliferation.

"The body is made up of cells that communicate with each other and with external cues via receptors at their surfaces. To generate cellular responses, signaling pathways are activated that initiate movement of proteins to specific locations inside the cells, notably the nucleus, where DNA is situated," said Diane Lidke, assistant professor at the University of New Mexico School of Medicine's department of pathology and lead author on the paper to be published Jan. 29 in the Journal of Biological Chemistry.

One particular pathway, the extracellular signal-regulated kinase (ERK) pathway, is altered in about 30 percent of all human cancers, said Lidke, who worked on the project during a postdoctoral stint in the lab of Thomas Jovin at the Max Planck Institute for Biophysical Chemistry. "It has been suspected for a long time that alterations of the ERK pathway could be the founding mutation behind cancers, and this was shown recently for melanoma."

ERKs act as messenger molecules by relaying signals that are received from outside the cell to the administrative core, the nucleus. To do so, ERK must move from its home in the intracellular fluid to the nucleus of the cell, turn on several genes while turning off others, which in turn finally tells the cell to divide or differentiate.

ERK's entry in the nucleus is unconventional, because the protein lacks the ability to bind to the known nuclear import proteins, Lidke said.

For more than a decade, scientists in this intense field of research thought that two molecules of ERK had to pair with each other after being activated in order to enter in the nu
'/>"/>

Contact: Angela Hopp
ahopp@asbmb.org
301-634-7389
American Society for Biochemistry and Molecular Biology
Source:Eurekalert  

Page: 1 2 3

Related biology news :

1. Bat researchers no longer flying blind on echolocation
2. Researchers trace effects of genetic defect in myotonic muscular dystrophy
3. Researchers identify a new gene involved in autophagy, the cellular recycling program
4. Researchers identify proteins that might contribute to memory loss and Alzheimers disease
5. University of Pittsburgh researchers launching trial of new osteoporosis drug
6. TGen-Scottsdale Healthcare researchers make breakthrough in lung cancer
7. Researchers discover genetic differences between lethal and treatable forms of leukemia
8. U of Alberta researchers find mechanism that could prevent or treat deadly peroxisome diseases
9. Researchers pin down long-elusive protein thats essential to life as we know it
10. Researchers use new acoustic tools to study marine mammals and fish
11. Researchers to investigate the genetics of congenital heart disease
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Researchers correct the record about behavior of important human protein tied to cancer
(Date:7/23/2014)... local and national governments struggle to deal with ever-growing ... refining the picture of just how much there is ... ACS journal Environmental Science & Technology , their ... developed countries discard floods into just seven developing countries ... who live there. , Knut Breivik and colleagues note ...
(Date:7/23/2014)... the International Journal of Fuzzy Systems ( ... Systems Association (TFSA). The cooperation will allow the journal ... fuzzy research., The International Journal of Fuzzy Systems ... with the theory, design and application of fuzzy systems, ... ranging from hardware to software. Launched in 1999, the ...
(Date:7/23/2014)... is available in German . ... modalities for orientation, some of which might be very ... the polarization pattern produced by sunlight in the atmosphere ... Max Planck Institute for Ornithology in Seewiesen, Germany, and ... that a night active mammal, the greater mouse-eared bat, ...
Breaking Biology News(10 mins):Bats use the evening sky's polarization pattern for orientation 2
... Sobrado, assistant professor of biochemistry at Virginia Tech, ... Prize, administered by the Ministry of Science and ... research is "a significant contribution to the diagnosis ... to a release distributed my MICIT. Sobrado, ...
... may have just provided the medical community a new way ... blocks of life forms and functions. University of Central ... program to analyze RNA motifs the subunits that make ... three building blocks of life along with DNA and proteins. ...
... in mice suggests a novel strategy for treating damaged ... approach potentially could improve cardiac function, minimize scar size, ... and avoid the risk of tissue rejection. In ... ONE , ( http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0030329 ) the researchers isolated and ...
Cached Biology News:Contributions to diagnosis, treatment of tropical diseases recognized 2Stem cell study in mice offers hope for treating heart attack patients 2Stem cell study in mice offers hope for treating heart attack patients 3
(Date:7/23/2014)... OncLive® is pleased to announce that ... Strategic Alliance Partnership program. , By participating ... will have the opportunity to work with the ... research initiatives, community-directed cancer prevention programs, and other ... OncLive to educate their peers by providing insights ...
(Date:7/22/2014)... 21, 2014 (PRWEB) July 23, 2014 ... Rutgers University. , The goal of the ... the full spectrum of scientists working in the ... development topics that represent the most promising directions ... to:,     Provide faculty and government ...
(Date:7/22/2014)... of rod-shaped metal nanoparticles in water with ultrasound and ... bits. Why? No one yet knows exactly. But researchers ... have clocked their speedand it,s fast. At up to ... faster than any nanoscale object submerged in liquid ever ... opened up the possibility that they could be used ...
(Date:7/22/2014)... CTD Holdings, Inc. (OTCQB:CTDH), a manufacturer ... cosmetics, and other markets, announced today that it has ... qualified private investors led by Novit L.P., an investment ... transaction involved the signing of a Securities Purchase Agreement ... Stock at a price per share of $1.00, resulting ...
Breaking Biology Technology:OncLive Expands Its Strategic Alliance Partnership Program With the Addition of UNC Lineberger Comprehensive Cancer Center 2OncLive Expands Its Strategic Alliance Partnership Program With the Addition of UNC Lineberger Comprehensive Cancer Center 3The 2014 NJ Symposium on Biomaterials Science Earns Society for Biomaterials Endorsement 2NIST shows ultrasonically propelled nanorods spin dizzyingly fast 2CTD Holdings Closes $1.725 Million Private Placement 2CTD Holdings Closes $1.725 Million Private Placement 3
... Sinobiopharma Pharmaceutical Group (OTC Bulletin Board: SNBP) is ... Tan as Director of Marketing.Ms. Tan joins Sinobiopharma ... as a China-based Unit Marketing Director for Organon, ... Organon, Ms. Tan held senior marketing management roles ...
... 8 Biopharmaceutical company Kiadis,Pharma reported preliminary ... mismatched bone marrow transplantations. Data was presented ... Roy during the prestigious,Presidential Symposium at the ... Goteborg, Sweden, on Monday, March 30, 2009. ...
... Inc. announced today that it has entered into ... NYSE: SNY ), providing the global ... platform for the research, development and commercialization of ... (ADCC). "We are extremely pleased about our partnership ...
Cached Biology Technology:Sinobiopharma, Inc. Appoints New Director of Marketing 2Kiadis Pharma Reports ATIR(TM) Clinical Data, Further Supporting its Potential in Mismatched Bone Marrow Transplantations 2BioWa Announces License of POTELLIGENT(R) Technology to sanofi-aventis 2
...
... is used as an internal standard for ... dilution mass spectrometry. 5-OxoETE is a polyunsaturated ... 5-HETE in human neutrophils. It stimulates cytosolic ... of 2 nM. 5-OxoETE selectively stimulates the ...
... Scalable SNPstream System Delivers 4,600 to ... GenomeLab SNPstream Genotyping System is capable of ... per day. Part of the GenomeLab family ... can process up to 48 SNPs in ...
... are a mixture of Strep•Tag® II fusion ... The markers provide precise size references for ... Coomassie blue. Because each of the proteins ... can also be detected by the Strep•Tag ...
Biology Products: