Navigation Links
Researchers continue to find genes for type 1 diabetes
Date:10/14/2008

Genetics researchers have identified two novel gene locations that raise the risk of type 1 diabetes. As they continue to reveal pieces of the complicated genetic puzzle for this disease, the researchers expect to improve predictive tests and devise preventive strategies.

"As we add to our knowledge of the biology of type 1 diabetes and better understand details of the disease's genetic risk, we will be able to develop better diagnostic tests that meaningfully predict who will develop diabetes," said study leader Hakon Hakonarson, M.D., Ph.D., director of the Center for Applied Genomics at The Children's Hospital of Philadelphia.

The study appeared online Oct. 7 in Diabetes, the journal of the American Diabetes Association. Hakonarson's co-leader in the study was Constantin Polychronakos, M.D., director of Pediatric Endocrinology at McGill University in Montreal.

Type 1 diabetes, formerly called juvenile diabetes, usually begins in childhood, when the body's immune system malfunctions and destroys insulin-producing beta cells in the pancreas. Without insulin, blood sugar levels run out of control and can impair blood flow and damage the eyes, nerves and kidneys. It is second only to asthma as the most common chronic disease in American children. Patients are dependent for life on insulin injections or insulin medications.

Type 1 diabetes is a complex disease, in which a variety of genes interact with each other to cause the biological events in the immune system that remove the body's control of blood sugar levels. Over the past two years, large research collaborations, including groups led by Hakonarson and Polychronakos, have used highly automated, sophisticated gene-scanning tools to pinpoint genes implicated in the disease.

Based on initial data from previous researchers, scientists in the current study refined their search in DNA samples of thousands of patients, family members and control subjects from P
'/>"/>

Contact: John Ascenzi
Ascenzi@email.chop.edu
267-426-6055
Children's Hospital of Philadelphia
Source:Eurekalert

2

GOOD

Page: 1 2

Related biology news :

1. Researchers identify proteins involved in new neurodegenerative syndrome
2. Texas researchers and educators head for Antarctica
3. MGH researchers describe new way to identify, evolve novel enzymes
4. University of Pennsylvania researchers develop formula to gauge risk of disease clusters
5. U of MN researchers discover noninvasive diagnostic tool for brain diseases
6. U of Minnesota researchers discover noninvasive diagnostic tool for brain diseases
7. Researchers discover new strategies for antibiotic resistance
8. Researchers find new taste in fruit flies: carbonated water
9. Binghamton University researchers investigate evolving malaria resistance
10. UIC researchers find promising new targets for antibiotics
11. Researchers develop simple method to create natural drug products
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/21/2013)... at the University of Illinois at Chicago College of Medicine ... stores fat -- its main energy source -- and how ... under a new $2 million, 4-year grant from the National ... changes how it uses fuel for energy. These changes may ... and are different in men and women, says E. Douglas ...
(Date:5/21/2013)... largest gathering of biomass experts , Where? ... When? 03-07 June 2013 , ... research, resource assessment, market and policy developments, manufacturing and ... world and benefiting from its 2013 edition from a ... than 60 countries, more than 240 plenary and oral ...
(Date:5/20/2013)... antibiotic colistin are also commonly resistant to antimicrobial ... a study in mBio , the online ... Cross-resistance to colistin and host antimicrobials LL-37 and ... attack, could mean that patients with life-threatening multi-drug ... immune response. Colistin is a last-line drug for ...
Breaking Biology News(10 mins):Do men's and women's hearts burn fuel differently? 221st European Biomass Conference and Exhibition 221st European Biomass Conference and Exhibition 321st European Biomass Conference and Exhibition 4Resistance to last-line antibiotic makes bacteria resistant to immune system 2Resistance to last-line antibiotic makes bacteria resistant to immune system 3
... , EAST LANSING, Mich. Two lines of pest-resistant ... promise healthier harvests for growers and a little green ... Aphid Shield" is the new trade name for genetics ... and soil science tested some 2,000 strains of soybeans ...
... Prairie dogs, once abundant in the Rocky Mountains ... by plague a virulent bacterial disease spread by ... dog towns with thousands of inhabitants, killing virtually the ... and build a new colony, which eventually is wiped ...
... 3, 2010 The American Chemical Society (ACS) will hold ... its 240th National Meeting & Exposition, featuring international authorities speaking ... on Climate Change Science and Consequences," it is scheduled for ... Ballroom B/C, and will include time for audience participation. ...
Cached Biology News:Pest-resistant soybeans grow out of MSU research lab 2Carnivorous mice spread deadly plague in prairie dog towns, Stanford study finds 2Carnivorous mice spread deadly plague in prairie dog towns, Stanford study finds 3Carnivorous mice spread deadly plague in prairie dog towns, Stanford study finds 4American Chemical Society to hold forum on climate change on Aug. 23 2
(Date:5/22/2013)... (PRWEB) May 22, 2013 iLuv Creative ... of accessories for the mobile lifestyle, announces they are ... protect, and manage multiple iPad devices efficiently. Winner of ... the 2012 Good Design award, MultiCharger-X is revolutionizing the ... wherever it is deployed. , MultiCharger-X (iAD910) ...
(Date:5/22/2013)... 2013  Empire Genomics announced today it has ... novel genomic biomarker from Cornell University for use ... help in diagnosing and determining treatment for patients ... Neuroendocrine prostate cancer (NEPC) is a lethal variant ... novo, but more commonly arises after hormonal therapy ...
(Date:5/22/2013)... -- Cleveland BioLabs, Inc. (NASDAQ: CBLI) today announced that the Company ... Microcap Conference, May 30, in New York, NY ... , CPA, Chief Financial Officer of Cleveland BioLabs, will present ... 1:30 p.m. Eastern Time.  A live and archived webcast of ... of the Cleveland BioLabs website at www.cbiolabs.com . ...
(Date:5/22/2013)... (PRWEB) May 22, 2013 Alton Housing Authority ... May 15, 2013 said that their presence has already ... bed bug sufferers avoid such big spending, My Cleaning Products ... inexpensively. , It was said in the report that to ... MCP related. Apart from that, its employees also attended a ...
Breaking Biology Technology:iLuv Now Shipping the All New MultiCharger-X 2iLuv Now Shipping the All New MultiCharger-X 3Empire Genomics Licenses Novel DNA Biomarker for Use in Diagnosing and Creating a Companion Diagnostic Test for Neuroendocrine Prostate Cancer 2Cleveland BioLabs to Present at Second Annual Marcum LLP Microcap Conference 2Bed Bugs Cost Alton Housing Authority $35,000; New Help, How to Kill Bed Bugs With Less Expense, Introduced by My Cleaning Products 2
... ALBUQUERQUE, N.M. Sandia National Laboratories researchers have taken ... the functionality of devices in the terahertz (THz) frequency ... the same chip to make a compact receiver, the ... formerly needed to couple the laser to the detector. ...
... 29 Sirnaomics, Inc. ( www.sirnaomics.com ) announced ... Business Innovation Research) grants from National Cancer Institute (NCI) ...  (NIAID), of National Institute of Health (NIH). ... is dedicated to developing RNA interference (RNAi) therapeutics for ...
... ... experts, policymakers, and celebrities on issues that affect us all. Viewers any where in ... issues raised in our comedy and shows. Over 60 controversial episodes and hundreds of ... ...
Cached Biology Technology:Sandia Labs reports first monolithic terahertz solid-state transceiver 2Sirnaomics Receives Two SBIR Grants from NIH for Developing siRNA Therapeutics to Treat Glioblastoma and Influenza Infection 2Sirnaomics Receives Two SBIR Grants from NIH for Developing siRNA Therapeutics to Treat Glioblastoma and Influenza Infection 3Sirnaomics Receives Two SBIR Grants from NIH for Developing siRNA Therapeutics to Treat Glioblastoma and Influenza Infection 4Bait and Switch TV's Free Live Debates Invite TV Viewers to Debate with Experts in Real Time about Controversial Topics 2Bait and Switch TV's Free Live Debates Invite TV Viewers to Debate with Experts in Real Time about Controversial Topics 3Bait and Switch TV's Free Live Debates Invite TV Viewers to Debate with Experts in Real Time about Controversial Topics 4Bait and Switch TV's Free Live Debates Invite TV Viewers to Debate with Experts in Real Time about Controversial Topics 5Bait and Switch TV's Free Live Debates Invite TV Viewers to Debate with Experts in Real Time about Controversial Topics 6
Contained in EZ-Tn5™ Kits and are available separately for sequencing of an insertion site....
p-Raf-1 (Ser 338/Tyr 341)-R...
Mouse monoclonal [Flt-1/EWC] to VEGF Receptor 1 ( Abpromise for all tested applications). entrezGeneID: 2321 SwissProtID: P17948...
MMP-1/8 (H-300)...
Biology Products: