Navigation Links
Researchers complete the first epigenome in Europe
Date:5/30/2012

A study led by Manel Esteller, director of the Epigenetics and Cancer Biology Program at the Bellvitge Biomedical Research Institute (IDIBELL), professor of genetics at the University of Barcelona and ICREA researcher, has completed the first epigenome in Europe. The finding is published in the latest issue of the international scientific journal Epigenetics.

The genome of all cells in the human body is the same for all of them, regardless their aspect and functions. Therefore, genome cannot fully explain the activity of tissues and organs and their disorders in complex diseases like cancer. It takes a further explanation. Part of this explanation is provided by epigenetics, a field of biology that studies the heredity activity of DNA that does not involve changes in its sequence. That is, if genetics is the alphabet, epigenetics is the spelling that guides the activity of our cells.

Methylation

Epigenetics refers to chemical changes in our genetic material and proteins that regulate it. The best-known epigenetic mark is the methylation, the addition of a methyl chemical group (-CH3) in our DNA. The epigenome consists of all the epigenetic marks of a living being.

The authors of the study have completed the epigenomes for all brands of methylation of DNA from white blood cells of two girls: a healthy one and a patient suffering from a rare genetic disease called Immunodeficiency, Centromere instability and Facial anomalies syndrome (ICF). This disease is caused by a mutation in a gene that causes the addition of a methyl chemical group in its DNA.

The analysis performed by the researchers reveals that the patient has an epigenomic defect that causes fragility of chromosomes, which thus can easily be broken. In addition, the study shows that the patient has a wrong epigenetic control of many genes related to the response against infection, which causes a severe immune deficiency.

The study coordinator, Manel Esteller, emphasizes that due to this study, "we now know what happens in this type of rare diseases and we can start thinking about strategies for new treatments based on this knowledge."

Dr. Esteller is an international leader in the field of epigenetics. His work has been crucial to show that all human tumours have in common a specific chemical alteration: the hypermethylation of tumour suppressor genes. Since 2008 is the director of the Epigenetics and Cancer Biology Program at IDIBELL.


'/>"/>

Contact: Jordi Morato
comunicacio@idibell.cat
IDIBELL-Bellvitge Biomedical Research Institute
Source:Eurekalert

Related biology news :

1. UC Santa Barbara researchers develop synthetic platelets
2. Researchers say tart cherries have the highest anti-inflammatory content of any food
3. CSHL researchers solve structure of human protein critical for silencing genes
4. Researchers identify genetic markers to predict male fertility
5. University of Hawaii Cancer Center researchers create new anti-cancer drug
6. UCLA researchers develop way to strengthen proteins with polymers
7. Tufts Medical Center researchers finds marker in premies saliva predicts readiness to feed by mouth
8. Researchers aim to assemble the tree of life for all 2 million named species
9. Dartmouth researchers are learning how exercise affects the brain
10. Nottingham researchers lead worlds largest study into pre-eclampsia
11. Begin early: Researchers say water with meals may encourage wiser choices
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/14/2016)... , April 14, 2016 ... and Malware Detection, today announced the appointment of ... the new role. Goldwerger,s leadership appointment comes ... the heels of the deployment of its platform at ... behavioral biometric technology, which discerns unique cognitive and physiological ...
(Date:3/31/2016)... March 31, 2016  Genomics firm Nabsys has completed ... Barrett Bready , M.D., who returned to the ... original technical leadership team, including Chief Technology Officer, ... Development, Steve Nurnberg and Vice President of Software and ... company. Dr. Bready served as CEO of ...
(Date:3/22/2016)... India , March 22, 2016 /PRNewswire/ ... market research report "Electronic Sensors Market for Consumer ... Proximity, & Others), Application (Communication & IT, ... Geography - Global Forecast to 2022", published ... industry is expected to reach USD 26.76 ...
Breaking Biology News(10 mins):
(Date:4/26/2016)... ... 2016 , ... Heidelberg Instruments, a leader in design, development ... Volume Pattern Generator (VPG) line of lithography systems. The breakthrough VPG+ system is ... a solution for mid volume direct write lithography applications. It utilizes the ...
(Date:4/26/2016)... ... ... This unique "Fertility Happy Hour" event will be held at The Saguaro Hotel ... on female fertility and the reproductive technologies that are empowering a new generation of ... The Arizona Center, will give a short presentation and answer questions about age ...
(Date:4/26/2016)... ... April 26, 2016 , ... Seattle based ... operating grant from 1Plus12 Corporation. The grant will be used to further the ... on the organization's website http://www.ivsci.org , In accounting the grant to ...
(Date:4/26/2016)... ... , ... uBiome, the leading microbial genomics company, welcomes Neil Grimmer, Co-founder and ... to co-founding Plum in 2007, Neil Grimmer was Vice President of Strategy and Innovation ... designer of ideas, products, and brands, Grimmer has been at the forefront of launching ...
Breaking Biology Technology: