Navigation Links
Researchers complete a milestone in defining the genetic basis of rheumatoid arthritis
Date:12/25/2013

MANHASSET, NY An international group of investigators has discovered new genes, pathways and cell types that are involved in inherited susceptibility to rheumatoid arthritis (RA). The findings are published online in Nature.

Scientists performed a genome-wide association study (GWAS) meta-analysis in more than 100,000 people of European and Asian descent. They discovered 42 new sites of genetic variation involved in risk for RA. The analysis provides specific locations of genes, DNA sequences or positions on chromosomes for these genetic differences, bringing the catalog of confirmed risk variants for RA to over 100 genetic loci. These findings lead to a better understanding of how new treatments could be developed.

"This study is the culmination of over a decade of work by an extraordinary group of collaborative scientists from around the world," said Peter K. Gregersen, a collaborator on the study, and head of the Robert S. Boas Center for Genomics and Human Genetics at the Feinstein Institute for Medical Research. "It provides us with a definitive list of the major common genetic variation involved in this disease, and points the way forward to develop new diagnostic and therapeutic approaches to this illness."

The lead investigator of the study, Robert Plenge, MD, PhD, director of Genetics and Genomics, Division of Rheumatology, Immunology and Allergy at Brigham and Women's Hospital added, "Our study provides a compelling link between human genetics in RA and approved therapies to treat RA. This leads to an intriguing question: can our new genetic discoveries lead to new therapies to treat or cure RA? Further, can a similar approach be used to develop therapies for other complex diseases such as lupus, diabetes and Alzheimer's disease?"

Rheumatoid arthritis is a long-term inflammatory disorder that may affect many tissues and organs, but principally attacks flexible joints. It can be a disabling and painful condition, which can lead to substantial loss of functioning and mobility if not adequately treated. The disease often leads to the destruction of cartilage and fusion of the joints. Rheumatoid arthritis can also produce inflammation in areas of the body including the lungs, membrane around the heart, and white of the eye.


'/>"/>

Contact: Emily Ng
eng3@nshs.edu
516-562-2670
North Shore-Long Island Jewish (LIJ) Health System
Source:Eurekalert  

Related biology news :

1. Study by UC Santa Barbara researchers suggests that bacteria communicate by touch
2. UC Santa Barbara researchers discover genetic link between visual pathways of hydras and humans
3. Researchers attempt to solve problems of antibiotic resistance and bee deaths in one
4. UNH researchers find African farmers need better climate change data to improve farming practices
5. Ottawa researchers to lead world-first clinical trial of stem cell therapy for septic shock
6. Researchers uncover molecular pathway through which common yeast becomes fungal pathogen
7. Researchers print live cells with a standard inkjet printer
8. Columbia Engineering and Penn researchers increase speed of single-molecule measurements
9. Researchers reveal how a single gene mutation leads to uncontrolled obesity
10. Researchers discover novel therapy for Crohns disease
11. New paper by Notre Dame researchers describes method for cleaning up nuclear waste
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Researchers complete a milestone in defining the genetic basis of rheumatoid arthritis
(Date:4/28/2016)... First quarter 2016:   , ... the first quarter of 2015 The gross margin was ... 18.8) and the operating margin was 40% (-13) Earnings ... flow from operations was SEK 249.9 M (21.2) , ... SEK 7,000-8,500 M. The operating margin for 2016 is ...
(Date:4/15/2016)... April 15, 2016 Research ... Gait Biometrics Market 2016-2020,"  report to their offering.  ... ) , ,The global gait biometrics market is ... during the period 2016-2020. Gait analysis ... can be used to compute factors that are ...
(Date:3/29/2016)... 2016 LegacyXChange, Inc. (OTC: ... SelectaDNA/CSI Protect are pleased to announce our successful effort ... variety of writing instruments, ensuring athletes signatures against counterfeiting ... from athletes on LegacyXChange will be assured of ongoing ... Bill Bollander , CEO states, "By ...
Breaking Biology News(10 mins):
(Date:4/27/2016)... ... April 27, 2016 , ... PathSensors, Inc., ... Advisory Board. Dr. Lamka will assist PathSensors in expanding the use of the ... deploys the CANARY® test platform for the detection of harmful pathogens, including a ...
(Date:4/27/2016)... April 27, 2016 MedDay, a biotechnology ... announces the appointment of Catherine Moukheibir as Chairman of its ... Chairman, Jean Jacques Garaud , who contributed to the ... effective immediately. Catherine started her career in strategy ... and London .  She held C-Suite level ...
(Date:4/26/2016)... CAMBRIDGE, Mass. (PRWEB) , ... April 26, 2016 , ... ... Herr has been selected as one of three finalists for the European Inventor ... the EPO’s annual innovation prize will be announced at a ceremony in Lisbon on ...
(Date:4/26/2016)... ... April 26, 2016 , ... BioFactura, Inc ., a ... round of financing. Healthy investor interest drove significant oversubscription of the original $1.5M ... known as biosimilars, to the advanced preclinical stages. , Chief Executive Officer and President, ...
Breaking Biology Technology: