Bondos is studying how many proteins are amenable to fusion with Ubx. "It looks like it's a fairly wide range, and even though Ubx is positively charged, both positively and negatively charged proteins can be incorporated." She said even proteins that don't directly fuse with Ubx may be able to connect through intermediary binding partners.
Bondos said the 2009 paper "showed we could make three-dimensional scaffolds. We can basically make rods and sheets and meld them together; anything you can build with Legos, we can build with Ubx."
Ubx-based materials can match the natural properties of elastin, the protein that makes skin and other tissues pliable, Bondos said. "You don't want to make a heart out of something hard, and you don't want to make a bone out of something soft," she said. "We can tune the mechanical properties by changing the diameter of the fibers."
She said functionalized Ubx offers a path to growing three-dimensional organs layer by layer. "We should be able to build something shaped like a heart, and because we can pattern the chimeras within fibers and films, we can build instructions into the material that cause cells to differentiate as muscle, nerves, vasculature and other things."
Bondos suggested the material might also be useful for replacing damaged nerves. "We should be able to stimulate cell attachment and nerve growth along the middle and factors on the ends to enhance attachment to existing nerve cells, to tie it into the patient. It really is pretty exciting."
Matthews said the ability to characterize and pattern fibers for different functions should find many uses, because enzymes, antibodies, growth factors and peptide recognition sequences can now be incorpo
|Contact: David Ruth|