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Researchers coat titanium with polymer to improve integration of joint replacements
Date:7/1/2008

the growth of bone around the implant and strength of the attachment of the implant to the bone.

Analysis of the bone-implant interface four weeks later revealed extensive and contiguous bone matrix and a 70 percent enhancement in the amount of contact between the implant and bone with the titanium implants coated with the engineered fibronectin fragment over the uncoated or RGD-coated titanium.

Garca and Petrie tested the fixation of the implants by measuring the amount of force required to pull the implants out of the bone. The study showed significantly higher mechanical fixation of the implants coated with the engineered fibronectin fragment over the implants with the other coating and uncoated titanium.

In addition to total joint replacements, Garca is studying how to fill large gaps between bones, which sometimes occur after a traumatic injury or tumor removal.

"We are developing a strategy to present peptides that encourage the surrounding bone to grow in and fill in around the gap," said Garca.

By improving communication with the body's cells, Garca can control the integration and healing response of the body to any implanted device. Currently, most become encapsulated by a collagen sheath, which affects the performance and long-term viability of the device. Garca aims to use these biomaterials to help integrate devices implanted in the body.


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Contact: Abby Vogel
avogel@gatech.edu
404-385-3364
Georgia Institute of Technology Research News
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