Navigation Links
Researchers coat titanium with polymer to improve integration of joint replacements


In this case, the polymer presented controlled amounts of an engineered protein that mimics fibronectin, a protein in the body that acts as a binding site for cell surface receptors called integrins.

It is important to control the integrins binding to the titanium implant because integrins provide signals that direct bone formation. Therefore, controlling integrin binding to the titanium will result in targeted signals that enhance bone formation around the implant.

To bind integrins to titanium, researchers previously coated titanium with a small biological signal containing the sequence arginine-glycine-aspartic acid (RGD) that binds to integrins. However, this region alone binds many different integrin receptors and with much less affinity than the full fibronectin protein.

"It has been common to mimic only very small sections of fibronectin, but when you take a small section and ignore the rest of the molecule you lose specificity and activity, and therefore signaling is impaired," said Garca.

For that reason, Garca engineered a much longer region of the same type of fibronectin that included the RGD peptide sequence as well as new sections also known to have sites that participate in integrin binding.

To evaluate the in vivo performance of the coated titanium in bone healing, chemists Raynor and Collard coated the surfaces of tiny clinical-grade titanium cylinders with the polymer brushes. Then engineers Petrie and Garca modified them with peptide sequences.

Two-millimeter circular defects were drilled into a rat's tibia bone and the cylinders were pressed into the holes. They tested three types of coatings: uncoated titanium, titanium coated with the RGD peptide and titanium coated with different densities of the engineered fibronectin fragment.

To investigate the function of these novel surfaces in promoting bone growth, the researchers quantified osseointegration, or

Contact: Abby Vogel
Georgia Institute of Technology Research News

Page: 1 2 3

Related biology news :

1. Researchers link early stem cell mutation to autism
2. Montreal Heart Institute and Mount Sinai Hospital researchers contribute to Crohns disease study
3. Salk researchers reprogram adult stem cells in their natural environment
4. UIC researchers make promising finding in severe lung disease
5. Montana State researchers release guide to noninvasive carnivore research
6. Growth hormones link to starvation may be clue to increasing life span, researchers find
7. Researchers explain nitrogen paradox in forests
8. UNH researchers test sediment-scrubbing technology in NH river
9. Florida researchers receive JDRF Excellence in Clinical Research Award
10. LIAI researchers discover new cellular mechanism that will significantly advance vaccine development
11. Stem cell researchers give old muscle new pep
Post Your Comments:
Related Image:
Researchers coat titanium with polymer to improve integration of joint replacements
(Date:7/23/2014)... Defense recently awarded the STEMPREP Project at Southern ... its goal of increasing the number of minorities ... middle school students for the two-summer classroom phase ... students with summer opportunities at research labs. , ... School of Education and Human Development, boasts an ...
(Date:7/23/2014)... North Carolina State University shows that urban "heat islands" ... States. One factor is that researchers have found warmer ... gloomy scale insect a significant tree pest ... times more adult gloomy scales on urban trees. , ... the gloomy scale in cities, and now we know ...
(Date:7/23/2014)... Honey bees, especially the young, are highly sensitive ... together to maintain temperatures within a narrow range. Recently ... at Tufts University,s School of Arts and Sciences, is ... heat within a hive in process similar to how ... vessels and skin. , "This study shows how ...
Breaking Biology News(10 mins):Department of Defense awards $2.6 million grant to SMU STEM program for minority students 2Urban heat boosts some pest populations 200-fold, killing red maples 2Urban heat boosts some pest populations 200-fold, killing red maples 3How honey bees stay cool 2
... researchers at The Johns Hopkins University School of Medicine reveal ... papers appear in the March issue of The Journal ... opening, many ion channels spontaneously close by inactivation, a process ... channels is important for a variety of biological processes, including ...
... Illinois study touts the benefits of soluble fiberfound in ... the inflammation associated with obesity-related diseases and strengthens the ... immune cellsthey go from being pro-inflammatory, angry cells to ... infection," said Gregory Freund, a professor in the U ...
... NEW ORLEANS, LA. Minerals Management Service (MMS) ... biologists have set sail to learn more about the ... Mexico. The first of the research cruise,s three legs ... is underway. The first and second legs of ...
Cached Biology News:An apple a day? Study shows soluble fiber boosts immune system 2An apple a day? Study shows soluble fiber boosts immune system 3MMS and NOAA scientists study prey of Gulf of Mexico sperm whales 2
(Date:7/23/2014)... Heroic worldwide conservation efforts have made great strides in ... in China, there are over 65 giant panda reserves ... But despite these efforts, just 1596 pandas remain in ... and zoos hope to save the panda by improving ... to the wild. Just how are these high-profile programs ...
(Date:7/23/2014)... Filippov (MIPT and Russian Quantum Center at Skolkovo) ... Republic, and the Institute of Physics in Bratislava, ... entanglement of particles passing through an amplifier and, ... Details are provided in an article published in ... preprint). , Quantum entangled particles are considered to ...
(Date:7/23/2014)... at the Helmholtz-Zentrum Dresden-Rossendorf (HZDR), the Vienna University ... have succeeded in embedding nearly perfect semiconductor crystals ... of producing hybrid nanowires, very fast and multi-functional ... chip in the future. The research results will ... . , Nano-optoelectronics are considered the cornerstone of ...
(Date:7/23/2014)... 23, 2014 /PRNewswire-iReach/ -- Think Drinks are a neuroscience-backed ... long term. They are the first functional focus beverage ... as an alternative to the temporary fix associated with ... on July 29, 2014, with hopes to raise $50,000 ... Photo - Think ...
Breaking Biology Technology:Scientists find way to maintain quantum entanglement in amplified signals 2Scientists find way to maintain quantum entanglement in amplified signals 3Scientists find way to maintain quantum entanglement in amplified signals 4A crystal wedding in the nanocosmos 2truBrain Neuroscientists To Launch More Effective, Healthier Alternative To Energy Drinks On Indiegogo 2
... scientists has determined the structure of the chlorophyll molecules in ... The team,s results one day could be used to build ... to electrical energy. A research paper about the discovery ... Proceedings of the National Academy of Sciences . , The ...
... 4 Meso Scale Diagnostics, LLC. (MSD) confirmed today ... the first identified case of infection with the 2009 ... Influenza Test, which is being developed under a contract ... is the investigational device referred to in the CDC,s ...
... May 4 Circ Pharma Limited ("Circ Pharma") ... have entered into a,Development Agreement to develop a ... to moderately severe pain. , ... delivery,technology enabling once daily dosing. Circ,s technology provides ...
Cached Biology Technology:Scientists determine the structure of highly efficient light-harvesting molecules in green bacteria 2Scientists determine the structure of highly efficient light-harvesting molecules in green bacteria 3Scientists determine the structure of highly efficient light-harvesting molecules in green bacteria 4Scientists determine the structure of highly efficient light-harvesting molecules in green bacteria 5Meso Scale Diagnostics' Point of Care Influenza Test Led to the First Identification of A(H1N1) Swine Flu Infection 2Circ Pharma Limited Enters Into Development Agreement for Chrono Tramadol With Elan Corporation Plc 2
... Certified USDA Research Registered OLAW Assured AAALAC ... AALAS Certified Technicians Documentation ... Upon Request Focus CRP is ... your custom immunology service needs. We ...
Applications: Western blotting ...
... data entry by collecting data from any ... Collect is extremely easy to use ... data entry. An excellent solution for ... spectrophotometers, force gauges, digital calipers, bar code ...
One unit is equal to 10Kb (insert DNA + vector). The final cost will increase or decrease according to the final assembled genome size. The price does not include genome annotation....
Biology Products: