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Researchers close in on origins of main ingredient of Alzheimer's plaques
Date:4/9/2008

beta production that requires endocytosis but doesn't need brain cell activity.

Cirrito conducted the research in the laboratories of co-senior authors David M. Holtzman, M.D., the Andrew B. and Gretchen P. Jones Professor and chair of the Department of Neurology at the School of Medicine, and neurologist-in-chief at Barnes-Jewish Hospital, and Steven J. Mennerick, Ph.D., associate professor of neurobiology and psychiatry.

Researchers already know several proteins on the surfaces of brain cells that bind to APP. They will be conducting follow-up studies to see if blocking these interactions can block APP endocytosis and reduce amyloid beta production.


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Contact: Michael Purdy
purdym@wustl.edu
314-286-0122
Washington University School of Medicine
Source:Eurekalert

Page: 1 2 3

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