Navigation Links
Researchers capture images of open channel that moves proteins across cell membranes
Date:10/23/2013

(Boston) Similar to passengers on an urban transit system, every protein made in the cell has a specific destination and function. Channels in cell membranes help direct these proteins to their appropriate target. Researchers at Boston University School of Medicine (BUSM) and their colleagues have now captured images of these channels as they open to allow proteins to pass through a membrane, while the proteins are being made. These findings are published as a Letter in Nature (Park, E. et al. 2013).

Christopher W. Akey, PhD, professor of physiology and biophysics at BUSM is a co-senior author of the Letter. In addition, the collaborating institutions include Harvard Medical School (HMS), Baylor College of Medicine (BCM) and Georgia Institute of Technology (GT).

Proteins, which are encoded by genes, are large molecules that perform specific functions. Many proteins such as hormones and growth factors are secreted by the cell and move into the bloodstream. These proteins are made in factories called ribosomes, which interact with a family of channels called Sec61/SecY that provide a path across the membrane. Initially, these nascent, or newly-made, proteins are inserted into channels as the proteins are being made. The channels also aid in inserting nascent proteins into the cell membrane where they function as receptors for drugs and form ion channels that function in vision and in transmitting nerve cell impulses.

In this study, researchers used samples made in E. coli bacteria to determine the structure of the highly conserved SecY channel. Using an electron microscope and computer analysis, researchers were able to capture images of the SecY channel opening when a nascent protein enters the central pore. In particular, the channel undergoes large movements that enlarge the central pore as a first step in allowing the nascent protein to cross the cell membrane and eventually travel to its destination.

"Similar to train cars that transport passengers through a tunnel, SecY/Sec61 channels help nascent proteins move across the cell membrane to reach their target in the body, and this study provides important insight about the function of these channels," said Akey.


'/>"/>

Contact: Jenny Eriksen Leary
jenny.eriksen@bmc.org
617-638-6841
Boston University Medical Center
Source:Eurekalert

Related biology news :

1. UAlberta medical researchers discover potential new treatment for colitis
2. Older siblings cells can be passed from female dogs to their puppies in the womb, MU researchers find
3. Nitrogen fertilizer remains in soils and leaks towards groundwater for decades, researchers find
4. Researchers discover innate virus-killing power in mammals
5. CNIO researchers delve into the behavior of cohesins
6. Rensselaer researchers propose new theory to explain seeds of life in asteroids
7. UT Dallas researchers find early success in new treatment for stroke recovery
8. University of Utah researchers receive NIH Directors New Innovator Award
9. UC Davis researchers discover a biological link between diabetes and heart disease
10. Researchers use smart phone photography to diagnose eye disease
11. University of Maryland researchers studying vaccine to prevent potential bird flu pandemic
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/3/2016)... LONDON , June 3, 2016 /PRNewswire/ ... Transport Management) von Nepal ... ,Angebot und Lieferung hochsicherer geprägter Kennzeichen, einschließlich ... weltweit führend in der Produktion und Implementierung ... an der Ausschreibung im Januar teilgenommen, aber ...
(Date:6/2/2016)... June 2, 2016   The Weather Company , an ... Ads, an industry-first capability in which consumers will be able ... to ask questions via voice or text and receive relevant ... Marketers have long sought an advertising solution ... can be personal, relevant and valuable; and can scale across ...
(Date:6/1/2016)... 2016 Favorable Government Initiatives Coupled ... Criminal Identification to Boost Global Biometrics System Market Through ... Research report, " Global Biometrics Market By Type, ... Opportunities, 2011 - 2021", the global biometrics market is ... account of growing security concerns across various end use ...
Breaking Biology News(10 mins):
(Date:6/27/2016)... 2016  Sequenom, Inc. (NASDAQ: SQNM ), ... through the development of innovative products and services, announced ... United States denied its petition to review ... Sequenom,s U.S. Patent No. 6,258,540 (",540 Patent") are not ... the Supreme Court,s Mayo Collaborative Services v. Prometheus Laboratories ...
(Date:6/27/2016)... 27, 2016  Liquid Biotech USA ... of a Sponsored Research Agreement with The University ... (CTCs) from cancer patients.  The funding will be ... correlate with clinical outcomes in cancer patients undergoing ... then be employed to support the design of ...
(Date:6/24/2016)... ... ... Researchers at the Universita Politecnica delle Marche in Ancona combed medical journal articles ... findings are the subject of a new article on the Surviving Mesothelioma website. ... blood, lung fluid or tissue of mesothelioma patients that can help point doctors to ...
(Date:6/23/2016)... , June 23, 2016 A person commits ... the crime scene to track the criminal down. ... U.S. Food and Drug Administration (FDA) uses DNA evidence to ... Sound far-fetched? It,s not. The FDA has ... to support investigations of foodborne illnesses. Put as simply as ...
Breaking Biology Technology: