Navigation Links
Researchers capture images of open channel that moves proteins across cell membranes
Date:10/23/2013

(Boston) Similar to passengers on an urban transit system, every protein made in the cell has a specific destination and function. Channels in cell membranes help direct these proteins to their appropriate target. Researchers at Boston University School of Medicine (BUSM) and their colleagues have now captured images of these channels as they open to allow proteins to pass through a membrane, while the proteins are being made. These findings are published as a Letter in Nature (Park, E. et al. 2013).

Christopher W. Akey, PhD, professor of physiology and biophysics at BUSM is a co-senior author of the Letter. In addition, the collaborating institutions include Harvard Medical School (HMS), Baylor College of Medicine (BCM) and Georgia Institute of Technology (GT).

Proteins, which are encoded by genes, are large molecules that perform specific functions. Many proteins such as hormones and growth factors are secreted by the cell and move into the bloodstream. These proteins are made in factories called ribosomes, which interact with a family of channels called Sec61/SecY that provide a path across the membrane. Initially, these nascent, or newly-made, proteins are inserted into channels as the proteins are being made. The channels also aid in inserting nascent proteins into the cell membrane where they function as receptors for drugs and form ion channels that function in vision and in transmitting nerve cell impulses.

In this study, researchers used samples made in E. coli bacteria to determine the structure of the highly conserved SecY channel. Using an electron microscope and computer analysis, researchers were able to capture images of the SecY channel opening when a nascent protein enters the central pore. In particular, the channel undergoes large movements that enlarge the central pore as a first step in allowing the nascent protein to cross the cell membrane and eventually travel to its destination.

"Similar to
'/>"/>

Contact: Jenny Eriksen Leary
jenny.eriksen@bmc.org
617-638-6841
Boston University Medical Center
Source:Eurekalert

Page: 1 2

Related biology news :

1. UAlberta medical researchers discover potential new treatment for colitis
2. Older siblings cells can be passed from female dogs to their puppies in the womb, MU researchers find
3. Nitrogen fertilizer remains in soils and leaks towards groundwater for decades, researchers find
4. Researchers discover innate virus-killing power in mammals
5. CNIO researchers delve into the behavior of cohesins
6. Rensselaer researchers propose new theory to explain seeds of life in asteroids
7. UT Dallas researchers find early success in new treatment for stroke recovery
8. University of Utah researchers receive NIH Directors New Innovator Award
9. UC Davis researchers discover a biological link between diabetes and heart disease
10. Researchers use smart phone photography to diagnose eye disease
11. University of Maryland researchers studying vaccine to prevent potential bird flu pandemic
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/21/2014)... is a key region in the global oceanic circulation. "On ... warm Atlantic water flows to the north into the Arctic ... and sea ice push their way out of the Arctic ... water cools here on its way to the north and ... in this manner drives the global band of oceanic currents ...
(Date:8/21/2014)... La. A team of researchers at ... method for using affordable, consumer-grade 3D printers ... that can contain antibacterial and chemotherapeutic compounds ... comprised of doctoral students and research faculty ... engineering programs collaborated to create filament extruders ...
(Date:8/20/2014)... In a study of 158 pregnant teenagers in ... craving and intentional consumption of ice, cornstarch, vacuum dust, ... a new Cornell study. , Moreover, such teens had ... did not eat nonfood substances. , Pregnant teens, regardless ... which can lead to iron deficiency and anemia. Low ...
Breaking Biology News(10 mins):Arctic sea ice influenced force of the Gulf Stream 2Arctic sea ice influenced force of the Gulf Stream 3Louisiana Tech University researchers use 3D printers to create custom medical implants 2Louisiana Tech University researchers use 3D printers to create custom medical implants 3Pica in pregnant teens linked to low iron 2
... explain the complexities of the origins of life. Their work, ... Interface , offers new insights into how RNA signaling likely ... that today,s genetic code probably resulted from a combination of ... student at NYU School of Medicine and the paper,s lead ...
... When a woman becomes pregnant, she knows it is important ... of herself and the health of her baby. New clinical ... Eurpean Federation of Periodontology (EFP) urge pregnant women to maintain ... periodontal disease may be at risk of adverse pregnancy outcomes, ...
... role of microbiology in agriculture combined with new technologies ... population increases according to a new report from the ... are essential partners in all aspects of plant physiology, ... solely on the plant," says Ian Sanders of University ...
Cached Biology News:Researchers develop model of 'near-optimal' genetic code 2Expectant mothers' periodontal health vital to health of her baby 2Report proposes microbiology's grand challenge to help feed the world 2
(Date:8/22/2014)... Greenville, SC (PRWEB) August 22, 2014 ... that indisputable acknowledgement is a national disgrace. Furthermore, ... part in establishing the current, deplorable state of ... outlined "5 great mistakes," to merely serve as ... convey the extent of colossal failure(s) that have ...
(Date:8/21/2014)... (PRWEB) August 21, 2014 ... Fertilizer Industry” is a professional and in-depth ... The report provides basic Seaweed Fertilizer information, ... industry chain structure as well as industry ... analysis, including domestic market as well as ...
(Date:8/21/2014)... BURLINGTON, Mass. , Aug. 21, 2014 /PRNewswire/ ... in Brazil and ... restrictions. The uptake of several newly approved agents, ... for this indication and the launch of emerging ... asthma markets. In particular, the emerging IL-5 inhibitors ...
(Date:8/21/2014)... Chester, NJ (PRWEB) August 21, 2014 ... of personal selling optimization technology and services for ... publication of “Grading Pharma’s Use of New Commercial ... of Measurement & Analytics. , The article examines ... marketing yield that are being tested in the ...
Breaking Biology Technology:5 Great Mistakes in Healthcare and How to Fix Them by Dr. Ira Williams 2Internationals Seaweed Fertilizer Industry 2014 Development Trend Analysis in New Research Study at DeepResearchReports.com 2Internationals Seaweed Fertilizer Industry 2014 Development Trend Analysis in New Research Study at DeepResearchReports.com 3Asthma Agents Currently Face a Suboptimal Coverage Environment in Brazil and Mexico, and as the Treatment Armamentarium Expands, Competitiveness Will Further Intensify 2Asthma Agents Currently Face a Suboptimal Coverage Environment in Brazil and Mexico, and as the Treatment Armamentarium Expands, Competitiveness Will Further Intensify 3Pursuit's Peter Robinson Publishes "Grading Pharma's Use of New Commercial Sales Models" 2
... -- Bruker AXS Inc. on Thursday announced the promotions ... to executive vice presidents, responsible for leading all aspects ... the Madison headquarters of Bruker AXS, now leads the ... as chief technology officer heads global R&D. , ,Burgaezy, ...
... describes today's go-it-alone economic climate than the word "entrepreneur." ... appealing to those who would strike out on their ... large and small along with colleges and universities and ... to help them in their quests to be successful ...
... CHICAGO -Last week, we talked about the size and ... key market segments. This week's column will focus on the ... , ,Before we comment on some trends from this ... absent here is the major part of the diagnostics business ...
Cached Biology Technology:Beware -- Use of the word 'entrepreneur' can put you in a legal mess 2Beware -- Use of the word 'entrepreneur' can put you in a legal mess 3Beware -- Use of the word 'entrepreneur' can put you in a legal mess 4Beware -- Use of the word 'entrepreneur' can put you in a legal mess 5Midwest plays key role in developing new medical device companies 2Midwest plays key role in developing new medical device companies 3
sterile filtered, off the clot, all male donors, Total Protein: 4.5 to 8.5 g/dl...
Recombinant Mouse MMP-9, CF...
Human/Mouse/Rat JNK Pan Specific Affinity Purified PAb...
Blue Standard is 3-cyano-7-hydroxycoumarin....
Biology Products: