Navigation Links
Researchers capture bacterial infection on film
Date:7/27/2009

Researchers have developed a new technique that allows them to make a movie of bacteria infecting their living host.

Whilst most studies of bacterial infection are done after the death of the infected organism, this system developed by scientists at the University of Bath and University of Exeter is the first to follow the progress of infection in real-time with living organisms.

The researchers used developing fruit fly embryos as a model organism, injecting fluorescently tagged bacteria into the embryos and observing their interaction with the insect's immune system using time-lapse confocal microscopy.

The researchers can also tag individual bacterial proteins to follow their movement and determine their specific roles in the infection process.

The scientists are hoping to use this system in the future with human pathogens such as Listeria and Trypanosomes. By observing how these bacteria interact with the immune system, researchers will gain a better understanding of how they cause an infection and could eventually lead to better antibacterial treatments.

Dr Will Wood, Research Fellow in the Department of Biology & Biochemistry at the University of Bath, explained: "Cells often behave very differently once they have been taken out of their natural environment and cultured in a petri dish.

"In the body, immune surveillance cells such as hemocytes (or macrophages in vertebrates) are exposed to a battery of signals from different sources. The cells integrate these signals and react to them accordingly.

"Once these cells are removed from this complex environment and cultured in a petri dish these signals are lost. Therefore it is really important to study whole organisms to fully understand how bacteria interact with their host."

Dr Nick Waterfield, co-author on the study and Research Officer at the University of Bath, said: "To be able to film the microscopic battle between single bacterial cells and immune cells in a whole animal and in real time is astounding.

"It will ultimately allow us to properly understand the dynamic nature of the infection process."

Professor Richard Ffrench-Constant, Professor of Molecular Natural History at the University of Exeter, added: "For the first time this allows us to actually examine infection in real time in a real animal it's a major advance!"


'/>"/>

Contact: Vicky Just
v.j.just@bath.ac.uk
44-122-538-6886
University of Bath
Source:Eurekalert  

Related biology news :

1. Researchers identify proteins involved in new neurodegenerative syndrome
2. Texas researchers and educators head for Antarctica
3. MGH researchers describe new way to identify, evolve novel enzymes
4. University of Pennsylvania researchers develop formula to gauge risk of disease clusters
5. U of MN researchers discover noninvasive diagnostic tool for brain diseases
6. U of Minnesota researchers discover noninvasive diagnostic tool for brain diseases
7. Researchers discover new strategies for antibiotic resistance
8. Researchers find new taste in fruit flies: carbonated water
9. Binghamton University researchers investigate evolving malaria resistance
10. UIC researchers find promising new targets for antibiotics
11. Researchers develop simple method to create natural drug products
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Researchers capture bacterial infection on film
(Date:11/29/2016)... CANNES, France , November 29, 2016 Nearly ... Continue Reading ... ... System is part of an efficient Identity Management. (PRNewsFoto/DERMALOG Identification Systems) ... DERMALOG is Germany's largest Multi-Biometric ...
(Date:11/21/2016)... Nov. 21, 2016   Neurotechnology , a ... technologies, today announced that the MegaMatcher On Card ... submitted for the NIST Minutiae Interoperability Exchange ... the mandatory steps of the evaluation protocol. ... continuing test of fingerprint templates used to establish ...
(Date:11/15/2016)... 2016  Synthetic Biologics, Inc. (NYSE MKT: SYN), ... the gut microbiome, today announced the pricing of ... its common stock and warrants to purchase 50,000,000 ... to the public of $1.00 per share and ... the offering, excluding the proceeds, if any from ...
Breaking Biology News(10 mins):
(Date:12/2/2016)... , ... December 01, 2016 , ... ... long-term client Nanowear on their recent FDA Class II 510(k) clearance for their ... significant hurdle in commercializing remote cardiac monitoring devices that rely on cloth-based nanosensors. ...
(Date:12/2/2016)... bioLytical Laboratories, a world leader in rapid infectious disease tests, introduced the Company,s newest ... members. (Photo: http://photos.prnewswire.com/prnh/20161201/444905 ) Continue Reading ... ... , , bioLytical was invited ... introduce the INSTI HIV Self Test to 350 pharmacy representatives in Nairobi ...
(Date:11/30/2016)... Nov. 30, 2016 Biotest Pharmaceuticals Corporation (BPC), ... to announce the addition of its newest plasma collection ... Nebraska . The 15,200 square foot state-of-the-art facility ... 2016 and brings the total number of BPC,s plasma ... Carlisle , BPC,s Chief Executive Officer said "We are ...
(Date:11/30/2016)... November 2016   Merck , ein ... Unterzeichnung einer Reihe von Vereinbarungen mit Evotec ... AG Screeningleistungen für Mercks Palette genetischer Reagenzien ... auf diese Bibliotheken in Kombination mit Evotecs ... Weg zur Ermittlung und Erforschung neuer Arzneimitteltargets.    ...
Breaking Biology Technology: