Navigation Links
Researchers build largest protein interaction map to date
Date:10/27/2011

we can sort of guess. But there's another third that we know nothing about. And now through this kind of analysis we can begin to explore the functions of these proteins. This is giving us extraordinary insight into how the cell works."

One significant use for such a map is to assess how a cell responds to changes in metabolic conditions, such as interactions with drugs or in conditions where genetic alterations occur. Finding such answers might lead to future drug treatments for disease, and perhaps to a deeper understanding of what occurs in conditions such as cancer.

"This is of extraordinary translational value," Artavanis-Tsakonas said. "In order to know how the proteins work you must know who they talk to. And then you can examine whether a disease somehow alters this conversation."

A pivotal part of this research involved a scientific technique called mass spectrometry, which is relatively new to the science of biology. The ultra-precise mass spectrometry experiments were done by HMS professor of cell biology Steven Gygi. Mass spectrometry is used to measure the exact weight (the mass) and thus identify each individual protein in a sample. It is a technique originally devised by physicists for analyzing atomic particles. But in recent years mass spectrometry was adapted and refined for new and powerful uses in basic biological research. Other studies using similar techniques to date have focussed on small groups of related proteins or single celled model organisms such as bacteria and yeast.

Despite the huge amount already known about the fruit fly and its genetic endowment, much about the function of thousands of proteins remains a mystery. This map, however, now gives us precice clues about their function. Filling in the detailed protein map can help scientists gain important insights into the process of development, that is, how a creature is put together, maintained and operated.

"Our analyses also sheds li
'/>"/>

Contact: David Cameron
david_cameron@hms.harvard.edu
617-432-0441
Harvard Medical School
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. WSU researchers demonstrate rare animal model for studying depression
2. UC Davis researchers discover complexities of DNA repair
3. Researchers generate first complete 3-D structures of bacterial chromosome
4. Researchers at NYU Langone Medical Center review the microbiome and its possible role in cancers
5. Researchers discover that same gene has opposite effects in prostate, breast cancers
6. Researchers do precise gene therapy without a needle
7. Researchers explore planktons shifting role in deep sea carbon storage
8. Stanford researchers examine impact of green politics on recent national elections
9. NIH grant will allow researchers to look for viral cause of most severe form of multiple sclerosis
10. UNH researchers receive NSF grant to scale up stream ecology
11. Medical College of Wisconsin researchers show molecule inhibits metastasis
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/27/2014)... Many African-Americans may not be getting effective doses of ... Hopkins suggests. The initial dosing studies, completed before the ... generally lack a protein that is key to removing ... people with maximum levels of the protein including ... maraviroc in their bodies compared to those who lack ...
(Date:8/27/2014)... it is related to ability that we already possess. ... melody more easily than learning how to hit a ... the Neural Basis of Cognition (CNBC)a joint program between ... a fundamental constraint in the brain that may explain ... the Aug. 28, 2014, issue of Nature , ...
(Date:8/27/2014)... invasive grass species frequently found in forests has created ... on American toads, a new University of Georgia study ... to the U.S. in the early 1900s, is one ... to more than a dozen states in the past ... and in forests, it can survive in widely diverse ...
Breaking Biology News(10 mins):Dosage of HIV drug may be ineffective for half of African-Americans 2Pitt and Carnegie Mellon engineers discover why learning can be difficult 2Pitt and Carnegie Mellon engineers discover why learning can be difficult 3More wolf spiders feasting on American toads due to invasive grass, UGA study shows 2More wolf spiders feasting on American toads due to invasive grass, UGA study shows 3
... the Medical College of Wisconsin, the Children,s Research Institute, ... rapid, automated system to differentiate strains of influenza. ... a rapid automated influenza A, influenza B, and RSV ... the 2009 H1N1 swine-origin influenza virus (S-OIV) epidemic in ...
... past decade, researchers have developed a variety of reliable real-time ... marine mammals and fish. These new sensors are now being ... with some very important practical results. Among them is improved ... to reduce ship strikes, a leading cause of their deaths. ...
... There is increased evidence that the Arctic could face ... Scientists documented evidence that the Arctic Ocean and Nordic ... the mid-Pliocene warm period (3.3 to 3 million years ago). ... projected for the end of this century, and is used ...
Cached Biology News:Researchers use new acoustic tools to study marine mammals and fish 2Arctic could face warmer and ice-free conditions 2
(Date:8/27/2014)... Salt Lake City, Utah (PRWEB) August 27, 2014 ... new construction that will expand its current Salt Lake ... operations currently underway outside of Utah to ultimately create ... the next 20 years. , “Utah is home ... many of whom can be credited with Varian’s success ...
(Date:8/27/2014)... 2014 In 2013, Lawrence ... Livermore National Security LLC (LLNS), was awarded ... a state-of-the-art laser system for the European Union's ... construction in the Czech Republic. , When commissioned ... called the " High repetition-rate Advanced Petawatt Laser ...
(Date:8/27/2014)... One of nature,s mysteries is how plants survive ... in the sun,s rays, while using this energy ... proteins in the plant,s blades quickly dissipate the ... protein quakes. Researchers at DTU Physics have now ... plants, algae and bacteria contain light-absorbing proteins which ...
(Date:8/27/2014)... DUBLIN , Aug. 27, 2014 ... of the "Global Lactic Acid  (Biodegradable Polymer, ... - Trends & Forecasts to 2019" report ... the simplest hydroxyl-carboxylic acid with an asymmetrical carbon ... in the biodegradable polymer, food and beverage, personal ...
Breaking Biology Technology:Varian Medical Systems Groundbreaking on Facility Expansion Triggers Influx of New Jobs to Salt Lake 2Varian Medical Systems Groundbreaking on Facility Expansion Triggers Influx of New Jobs to Salt Lake 3LLNL Synchs up with ELI Beamlines on Timing System 2LLNL Synchs up with ELI Beamlines on Timing System 3DTU researchers film protein quake for the first time 2Global Lactic Acid (Biodegradable Polymer, Food & Beverage, Personal Care & Pharmaceutical) Market - Trends & Forecasts to 2019 2
... strikes in London five years ago - the 7/7 transit ... for the Study of Terrorism and Responses to Terrorism (START), ... the rise in the number of new terror groups and ... are usually far more lethal. The report is based on ...
... school in Grenoble, France, and Virginia Tech is using ... students, work will help gene synthesis companies and their ... as harmful agents for bioterrorism. Synthetic biology offers ... agriculture, and other areas. For a few thousand dollars, ...
... University of Hawaii at Manoa,s School of Ocean Earth ... of Sea Disposal Site Hawaii Number 5 (HI-05), a ... approximately 5 miles south of Pearl Harbor, Oahu, Hawaii. ... sidescan sonar and remotely operated underwater vehicles to locate ...
Cached Biology Technology:Rise in new terror groups globally, fewer coordinated attacks, report finds 2iGEM team helps prevent rogue use of synthetic biology 2University of Hawaii completes 3-year investigation of military munitions sea disposal site 2University of Hawaii completes 3-year investigation of military munitions sea disposal site 3