Navigation Links
Researchers attack HIV's final defenses before drug-resistant mutations emerge
Date:1/16/2013

is working with researchers at the University of Pittsburgh and University of Minnesota to design drugs that target the RNase H enzyme and inhibit its activity. While the enzyme has been extremely difficult to target so far, Sarafianos and his colleagues believe they now know enough about the structure of RNase H to launch a promising new drug development program.

Parniak has spent more than 15 years studying the RNase H enzyme and developing antiviral drugs for HIV/AIDS, and he and Sarafianos have collaborated on research projects for more than six years. Together, they solved the framework of an RNase H fragment, mapping out the molecular details of its crystal structure and providing a roadmap for their current research.

"If we know what the lock looks like, we can make the key," Sarafianos said. "Knowing the crystal structure gives us the framework for designing the most potent compounds that target the RNase H enzyme, which is a novel and key target for antiretroviral drug discovery."

Parniak, an expert in virology and pharmacological analysis, has identified more than 3,000 different leads for compounds that could target RNase H. However, he said it's Sarafianos' expertise and experience in crystal structures that will allow them to design the best compounds that will be then synthesized at the University of Minnesota.

"Dr. Sarafianos brings a fresh approach," Parniak said. "He has the perfect combination of skills and knowledge to move this project forward. If anyone can solve this, it's him."

In addition to targeting the HIV virus, the behavior present in the RNase H enzyme is also present in more common viruses, such as Hepatitis B. Two billion people worldwide have been infected with the Hepatitis B virus, and about 600,000 people die every year as a result of Hepatitis B infection.

"The knowledge that we gain for developing drugs against the RNase of HIV could eventually be applied toward designing dr
'/>"/>

Contact: Laura Gerding
gerdingla@health.missouri.edu
573-882-9193
University of Missouri School of Medicine
Source:Eurekalert  

0

GOOD

Page: 1 2 3

Related biology news :

1. Study by UC Santa Barbara researchers suggests that bacteria communicate by touch
2. UC Santa Barbara researchers discover genetic link between visual pathways of hydras and humans
3. Researchers attempt to solve problems of antibiotic resistance and bee deaths in one
4. UNH researchers find African farmers need better climate change data to improve farming practices
5. Ottawa researchers to lead world-first clinical trial of stem cell therapy for septic shock
6. Researchers uncover molecular pathway through which common yeast becomes fungal pathogen
7. Researchers print live cells with a standard inkjet printer
8. Columbia Engineering and Penn researchers increase speed of single-molecule measurements
9. Researchers reveal how a single gene mutation leads to uncontrolled obesity
10. Researchers discover novel therapy for Crohns disease
11. New paper by Notre Dame researchers describes method for cleaning up nuclear waste
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Researchers attack HIV's final defenses before drug-resistant mutations emerge
(Date:6/18/2013)... 2013 The herbal extract of a yellow-flowered mountain ... increase the lifespan of fruit fly populations by an ... , But it,s how Rhodiola rosea ... grabbed the attention of study leaders Mahtab Jafari and ... in a manner completely unrelated to dietary restriction and ...
(Date:6/17/2013)... MA Women in the U.S. exposed to high levels ... likely to have a child with autism as women who ... study from Harvard School of Public Health (HSPH). It is ... and air pollution across the U.S. , "Our findings raise ... the women in our study lived in areas where risk ...
(Date:6/17/2013)... On June 6, professors in Wayne State ... National Science Foundation-funded (NSF) Research Experience for Undergraduates ... an opportunity to do cutting-edge research in astrophysics, ... According to Alexey Petrov, Ph.D., professor of physics ... principal investigator and program director of the grant, ...
Breaking Biology News(10 mins):Herbal extract boosts fruit fly lifespan by nearly 25 percent, UCI study finds 2Exposure to high pollution levels during pregnancy may increase risk of having child with autism 2Wayne State welcomes undergraduates from around the US for physics research experience 2
... A study by researchers at the University of California, San Diego ... in Tijuana, Mexico is increasing, and much higher than had been ... a team of researchers working in San Diego and Mexico to ... , The number of men and women aged 15 to ...
... A rare frog that lives in rushing streams and waterfalls ... the roar of flowing water by communicating ultrasonically, scientists reported ... frog to hear ultrasounds are made possible by the presence ... , "Our research points out an elegant and novel solution ...
... first conclusive evidence that neurodevelopmental disorders such as ... disease, Parkinson's disease and ataxias can be caused, ... that interfere with the electrical impulses of rapid-firing ... implicated gene, KCNC3, and two mutations are described ...
Cached Biology News:HIV/AIDS rates in Tijuana, Mexico increasing at alarming rate 2HIV/AIDS rates in Tijuana, Mexico increasing at alarming rate 3Frog’s ear canal may provide insights for understanding human hearing loss 2Frog’s ear canal may provide insights for understanding human hearing loss 3Study ties 'new' cell-death mechanism to developmental and degenerative brain disorders 2Study ties 'new' cell-death mechanism to developmental and degenerative brain disorders 3
(Date:6/18/2013)... June 18, 2013 Though health care ... according to the U.S. Bureau of Labor Statistics -- the ... 24,000 per month. Most new health care jobs were added ... sector saw a loss of 6,000 jobs. Overall, the U.S. ... firm Challenger, Gray & Christmas reported that a total of ...
(Date:6/18/2013)... June 18, 2013 Earlier this year, Google ... platform. As this directly impacts the core component of ... one of the most sweeping updates since its inception in ... Technologies recently posted a very informative article on ... ‘must-have’ upgrade date for enhanced campaigns . Only ...
(Date:6/18/2013)... Kitware , a leading developer ... Fast-Track award from the U.S. Department of Energy for ... the nuclear power industry. , Construction of nuclear power ... years, but the United States’ nuclear power industry has ... plant utilization through improved refueling, maintenance, and safety systems ...
(Date:6/17/2013)... Fort Belvoir, VA (PRWEB) June 17, 2013 ... its annual Basic Research Technical Review at the Waterford ... 2. More than 300 grant awardees will present technical ... research. Technical sessions will cover a broad range of ... Recognition; (2) Cognitive, Information and Network Science; (3) Science ...
Breaking Biology Technology:MedZilla Employment Report for June 2013 -- Jobs in Health Care Grow, But at Slower Pace 2MedZilla Employment Report for June 2013 -- Jobs in Health Care Grow, But at Slower Pace 3Core and More Technologies Helps Organizations Migrate to Google’s Enhanced Campaign Structure 2Core and More Technologies Helps Organizations Migrate to Google’s Enhanced Campaign Structure 3Kitware to Develop an Open-Source HPC Design-Analysis Environment for Nuclear Energy Research 2Invitation to Register: Annual Defense Threat Reduction Agency Basic Research Technical Review 2
... Also Shows Stable Attitudes on Using Biotechnology for Food Production , ... ... the need to feed more people with fewer resources becomes increasingly challenging, ... more people are thinking about the concept of sustainable food production and ...
... 23 MedImmune today announced,that researchers will present ... Annual Meeting of the American College of Rheumatology, ... Center in San Francisco, California., "MedImmune is ... patients,struggling with systemic autoimmune rheumatic diseases," said Barbara,White, ...
... Authored A New Understanding Of Heart Failure, LA ... Board: DSKA) ("Duska") announced today that Jonathan S.,Stamler, M.D., ... advise on the clinical development of CDP-1050, a drug ... is the George Barth Geller Professor of Research in,Cardiovascular ...
Cached Biology Technology:Consumers Looking to Sustainable Food Production to Feed Global Population 2Consumers Looking to Sustainable Food Production to Feed Global Population 3Consumers Looking to Sustainable Food Production to Feed Global Population 4Consumers Looking to Sustainable Food Production to Feed Global Population 5MedImmune Presents Data Highlighting its Progressive Inflammatory Disease Portfolio at the 72nd Annual Meeting of the American College of Rheumatology 2MedImmune Presents Data Highlighting its Progressive Inflammatory Disease Portfolio at the 72nd Annual Meeting of the American College of Rheumatology 3Leading Heart Specialist Joins Duska Therapeutics as Scientific Consultant 2Leading Heart Specialist Joins Duska Therapeutics as Scientific Consultant 3Leading Heart Specialist Joins Duska Therapeutics as Scientific Consultant 4Leading Heart Specialist Joins Duska Therapeutics as Scientific Consultant 5
normal rat IgM AF647...
Chicken anti-EEA1...
Animal Origin Free...
... Cell Dissociation Buffers are membrane-filtered ... salts chelating agents and cell-conditioning agents ... balanced salt solution or Ca2+- ... dissociation of mammalian cells from support ...
Biology Products: