Navigation Links
Researchers attack HIV's final defenses before drug-resistant mutations emerge
Date:1/16/2013

Scientists who study HIV are facing a troubling consequence of their own success. They created drugs that can now give infected patients almost normal life expectancy. However, those same drugs will eventually cause the constantly mutating virus to evolve into a form that eludes current treatments.

With a new $3.4 million grant from the National Institutes of Health, the University of Missouri is leading a team of researchers who want to stay a step ahead of HIV by finding new pathways for shutting down the virus. The scientists are developing new compounds designed to target an enzyme in HIV called RNase H, which has escaped the reach of existing drugs.

"Patients stay on these drugs for decades, so there will come a point where resistant strains of the virus will develop," said Stefan Sarafianos, PhD, principal investigator for the NIH project and Chancellor's Chair for Excellence in Molecular Virology at MU. "Our goal is to be ready for the mutating virus with new treatment options so we're not left empty-handed."

As HIV copies itself in humans, it can mutate into forms that escape the effects of previously effective treatments. More than 1.1 million people in the United States live with HIV infection, and 1 in 5 are unaware they are infected. HIV is one of the world's leading infectious killers, claiming more than 25 million lives over the past three decades.

"There are four enzymes present in HIV, and there are current drugs that target three of those enzymes," said Michael Parniak, PhD, co-investigator for the project and professor of microbiology and molecular genetics at the University of Pittsburgh. "RNase H is the last HIV enzyme being targeted, and there are no compounds currently in preclinical development designed for it."

Sarafianos
'/>"/>

Contact: Laura Gerding
gerdingla@health.missouri.edu
573-882-9193
University of Missouri School of Medicine
Source:Eurekalert  

Page: 1 2 3

Related biology news :

1. Study by UC Santa Barbara researchers suggests that bacteria communicate by touch
2. UC Santa Barbara researchers discover genetic link between visual pathways of hydras and humans
3. Researchers attempt to solve problems of antibiotic resistance and bee deaths in one
4. UNH researchers find African farmers need better climate change data to improve farming practices
5. Ottawa researchers to lead world-first clinical trial of stem cell therapy for septic shock
6. Researchers uncover molecular pathway through which common yeast becomes fungal pathogen
7. Researchers print live cells with a standard inkjet printer
8. Columbia Engineering and Penn researchers increase speed of single-molecule measurements
9. Researchers reveal how a single gene mutation leads to uncontrolled obesity
10. Researchers discover novel therapy for Crohns disease
11. New paper by Notre Dame researchers describes method for cleaning up nuclear waste
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Researchers attack HIV's final defenses before drug-resistant mutations emerge
(Date:10/18/2014)... Berlin, 19th October 2014 Psychological stress and stress-related ... for aging-related diseases, but the molecular mechanisms ... mechanisms may contribute to the development of ... treatments for these devastating diseases. This work ... Neuropsychopharmacology congress in Berlin., Now an international ...
(Date:10/17/2014)... of Copenhagen have shown for the first time how ... fibrosis patients, giving them the opportunity to get tremendous ... , The study also discovered the bacterial growth in ... halted or slowed down by the immune cells. The ... and helped "suffocate" the bacteria, forcing the bacteria to ...
(Date:10/16/2014)... how the bowel lining develops and, in the process, ... , The researchers produced evidence that stem cells are ... a feature of the bowel lining, and believe these ... controversial finding as scientists are still divided on the ... Chin Wee Tan and Professor Tony Burgess from the ...
Breaking Biology News(10 mins):Researchers find why depression and aging linked to increased disease risk 2Scientists opens black box on bacterial growth in cystic fibrosis lung infection 2Cryptic clues drive new theory of bowel cancer development 2
... Plant Science Center (PSC) have clarified a key epigenetic ... Arabidopsis protects cells from harmful DNA elements. Published in ... Genetics , the finding contributes to advancing our understanding ... plants and animals, opening the door to applications in ...
... Professor Cyrus Cooper, Professor of Rheumatology and Director ... has been awarded the Heberden Medal of the British ... Musculoskeletal Research Programme at the University of Southampton for ... 2003. His research programme has focused on ...
... WASHINGTONA bill in Oregon that would provide incentives to deliver ... the state,s residents and, at the same time, create hundreds ... according to a study released by Upstream Public Health in ... Health Impact Project, a collaboration of the Robert Wood Johnson ...
Cached Biology News:Discovery of DNA silencing mechanism reveals how plants protect their genome 2Oregon Farm to School bill would benefit health through job creation, study finds 2Oregon Farm to School bill would benefit health through job creation, study finds 3
(Date:10/20/2014)... Richardson, Texas (PRWEB) October 20, 2014 ... today announced that a team from Iowa State University ... * design contest. Using a Convey HC-2ex, the team’s ... than 14 times faster than the second place finisher. ... academic world embarked upon the month long challenge, using ...
(Date:10/20/2014)... Oct. 20, 2014  GenVec, Inc. (NASDAQ: GNVC ... , Ph.D., from its board of directors effective on October ... 2003, and served as its chairman from June 2006 to ... Nominating and Corporate Governance and Audit Committees of the board.  ... a decade of dedicated service to GenVec, and its stockholders," ...
(Date:10/20/2014)... 2014 Local veterinary surgeon, Dr. Tim ... study of donor stem cells for dogs with osteoarthritis. ... and has performed clinical stem cell therapy for 7 ... determine if a single injection of donor stem cells ... reduce pain and inflammation in the treated joints. ...
(Date:10/19/2014)... The Asia-Pacific Bromine Market report defines ... analysis and forecast of revenue. , Browse through ... report, to get an idea of the in-depth ... the segmentation in the Asia-Pacific bromine market, and ... , http://www.micromarketmonitor.com/market/asia-pacific-bromine-6741503144.html , Bromine is a ...
Breaking Biology Technology:Team from Iowa State Wins 2014 MemoCODE Design Contest Using Convey HC-2ex 2Team from Iowa State Wins 2014 MemoCODE Design Contest Using Convey HC-2ex 3Zola P. Horovitz To Retire From GenVec Board 2Cascade Veterinary Referral Center Seeks Candidates for an Investigational Study of Stem Cells for Dogs with Arthritis 2The Asia-Pacific Bromine Market is estimated to grow to $4,080.1 million by 2018 - New Report by MicroMarket Monitor 2The Asia-Pacific Bromine Market is estimated to grow to $4,080.1 million by 2018 - New Report by MicroMarket Monitor 3
... (OTC Bulletin Board: BNET) announced that notification was received,today ... System" has been granted by the Commonwealth of Australia,Patent ... The,official filing date is approved as November 8, 2001 ... date of November 8, 2021., This patent now ...
... N.J., Sept. 25 Osteotech, Inc.,(Nasdaq: OSTE ), ... for,regenerative medicine, announced today the appointment of Cato T.,Laurencin, ... joined the,Board of Directors effective September 24, 2008 and ... of the Board of Directors., Kenneth P. Fallon, ...
... Vanda,Pharmaceuticals Inc. (Nasdaq: VNDA ), a ... of clinical-stage product candidates,for central nervous system ... of Vanda Pharmaceuticals Inc. (the "Company") declared ... Right (a "Right") on each,outstanding share of ...
Cached Biology Technology:Bion Announces Approval of New Australian Patent for Low Oxygen Organic Waste Bioconversion for Livestock Waste Environmental Treatment 2Cato T. Laurencin, M.D., Ph.D. to Join Osteotech Board of Directors 2Vanda Pharmaceuticals Declares Dividend Distribution of Preferred Stock Purchase Rights 2Vanda Pharmaceuticals Declares Dividend Distribution of Preferred Stock Purchase Rights 3
... positive control for ChIP assays. Efficient fixation ... is a crucial step for the Chromatin-immunoprecipitation ... probably the most important parameter. Two major ... be taken into account: first, an excess ...
Mouse monoclonal [M2II-12] to MRP2 ( Abpromise for all tested applications). entrezGeneID: 1244 SwissProtID: Q92887...
The Programmable MP-5000P-F Power Supply can be applied for any Microfluidic application....
Rab GDP dissociation inhibitor beta...
Biology Products: