Navigation Links
Researchers at UGent and VIB, discovered potential novel treatment against septic shock
Date:2/7/2014

Septic shock is caused by excessive and systemic reaction of the entire body against infectious agents, in most cases of bacterial origin. The number of deaths by septic shock in intensive care units is very high and is still increasing, despite numerous large scale clinical trials. Scientists of VIB and UGent, supervised by Peter Vandenabeele, demonstrated in a mouse study that a potential novel treatment for sepsis may consist of the simultaneous neutralization of two harmful cytokines in the blood circulation, namely interleukin-1 and interleukin-18.

In the VIB research unit of Peter Vandenabeele, postdoctoral researcher Tom Vanden Berghe, in collaboration with Anje Cauwels, discovered a novel potential treatment for sepsis based on a combination strategy. The study was performed in mice and revealed that it is crucial to neutralize two harmful cytokines in the blood circulation simultaneously, more specifically interleukin-1 and interleukin-18. Neutralization of interleukin-1 is currently being used for the treatment of acute rheumatoid arthritis, while neutralization of interleukin-18 has been proposed for the treatment of several other inflammatory diseases.

Peter Vandenabeele (VIB/UGent): "Hitting one target is not sufficient. Biology is full of pleiotropy and synergism, also in diseases. Hitting multiple targets, also in septic shock, may be the way to go".

The application of the novel combined therapy for the treatment of septic patients in the hospital may benefit from the fact that each of those anti-cytokine treatments is already in clinical use. This may create renewed hope for the fight against this life-threatening disease, which is still increasing due to antibiotic-resistant bacteria as well as the growing number of patients whose immune system is weakened by disease or therapy (for example cancer, auto-immune diseases, organ transplantation, and diabetes).

These new findings strengthen our growing awarene
'/>"/>

Contact: Kris Van der Beken
info@vib.be
32-924-46611
VIB (the Flanders Institute for Biotechnology)
Source:Eurekalert

Page: 1 2

Related biology news :

1. Grant to help researchers find leukemias hiding places
2. Researchers discover rare new species of deep-diving whale
3. Presence of humans and urban landscapes increase illness in songbirds, researchers find
4. Researchers build 3-D structures to test breast cancer treatments
5. New hope: Researchers discover genetic mutations that cause rare and deadly lung disease
6. Stanford researchers discover how brain regions work together, or alone
7. Researchers identify 9 steps to save waterways
8. Zebra fish fins help Oregon researchers gain insight into bone regeneration
9. Researchers reverse some lung diseases in mice by coaxing production of healthy cells
10. CU-Boulder researchers sequence worlds first butterfly bacteria, find surprises
11. Dartmouth researchers develop new tool to identify genetic risk factors
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/26/2014)... a pen a New Zealand endemic tree has for the ... group of ,weedy, Australian shrubs and small trees. A New ... surprises and discover astonishing cryptic diversity behind what was long ... the open access journal PhytoKeys . , ... was one of the many discoveries made in the north-western ...
(Date:8/26/2014)... such as global warming and poverty the result ... fall on our failure as consumers to make ... in the Journal of Consumer Research , ... problems from governments to consumers and ultimately benefits ... politicians to encourage responsible consumption instead of implementing ...
(Date:8/26/2014)... planet can produce much more land-plant biomass the ... other terrestrial plant parts than previously thought. , ... and Technology , recalculates the theoretical limit of terrestrial ... than many current estimates allow. , "When you try ... to make some simplifying assumptions," said University of Illinois ...
Breaking Biology News(10 mins):And then there were 10 -- unexpected diversity in New Zealand kanuka genus Kunzea 2And then there were 10 -- unexpected diversity in New Zealand kanuka genus Kunzea 3An inconvenient truth: Does responsible consumption benefit corporations more than society? 2Study: Earth can sustain more terrestrial plant growth than previously thought 2Study: Earth can sustain more terrestrial plant growth than previously thought 3
... A new study by civil engineers at MIT shows that using ... by as much as 3 percent a savings that could ... or $15.6 billion at today,s oil prices. This would result in ... tons. The study, released in a recent peer-reviewed report, ...
... JOSE, Calif., May 22, 2012 /PRNewswire-iReach/ -- ... announces that Chief Technology Officer, Sebastien Taveau, will participate ... at NFC Solutions Summit 2012. The session will take place ... San Francisco Airport, in Burlingame, CA. At ...
... Hebrew University of Jerusalem have achieved, for the first ... of Fragile X patients. The discovery paves the way ... expression in Fragile X patients. Fragile X syndrome ... affecting hundreds of thousands of patients worldwide. The syndrome ...
Cached Biology News:Civil engineers find savings where the rubber meets the road 2Civil engineers find savings where the rubber meets the road 3Validity CTO to Present Natural ID Solutions for Improving Mobile Risk Management and User Experience at NFC Solutions Summit 2012 2Stem cell research paves way for progress on dealing with Fragile X retardation 2
(Date:8/26/2014)... Aug. 26, 2014 An analysis by Replikins, ... all Dengue virus strains in Pubmed, has revealed extensive ... 1944. This conservation and sharing of specific Replikin gene ... Blocker-Vaccine™ candidate, as it did for the H5N1 influenza ... which have been found to be effective (1,2). ...
(Date:8/26/2014)... Aug. 26, 2014 Technology Applications International ... (NUUU) has two (2) wholly- owned subsidiaries, Renuell ... harness scientifically advanced technology to provide advanced solutions ... Renuell Int,l, Inc. is launching its REJUVEL ... products that is made possible because of its ...
(Date:8/26/2014)... (PRWEB) August 26, 2014 Genedata, ... drug discovery and life science research, today announced ... will be held in Asia, Europe, and ... global pharmaceutical companies and leading research organizations will ... best practices, case studies, and upcoming challenges in ...
(Date:8/26/2014)... , Aug. 26, 2014  Guardant Health, ... commercialization of oncology diagnostic products, has been recognized ... 2015 Technology Pioneer . As an innovator ... of 24 companies across a wide variety of ... Guardant360 ® , Guardant Health,s ...
Breaking Biology Technology:Technology Applications International Corporation, Trading Symbol NUUU now trading on NASDAQ's Over the Counter Bulletin Board (OTC BB) 2Thought Leaders to Explore Innovations in SPR & Combination Screening at Genedata Screener User Group Meetings 2Thought Leaders to Explore Innovations in SPR & Combination Screening at Genedata Screener User Group Meetings 3Guardant Health Named a 2015 Technology Pioneer by World Economic Forum 2
... whopping portfolio of 16 Nanotechnology products and processes ... Release" organized to mark the fifty-second anniversary celebrations ... the portfolio, Director, Center of Excellence in Nanotechnology ... set of products and processes demonstrates potential development ...
... EAST LANSING, Mich. Researchers at Michigan State University ... while cleaning up nuclear waste and other toxic metals. ... and patented, are published in the current issue of ... The implications could eventually benefit sites forever changed ...
... WEST LAFAYETTE, Ind. - Researchers are making progress in ... sidestepping an obstacle thought to dramatically limit the material,s ... a one-atom-thick layer of carbon that conducts electricity with ... 2004 - which earned a Nobel Prize in physics ...
Cached Biology Technology:AIT unveils portfolio of 16 nanotechnology products 2Microbes generate electricity while cleaning up nuclear waste 2Innovation is step toward digital graphene transistors 2
... The CopyControl™ vector can be induced prior ... vectors provide the stability of single-copy BACs ... or other cloning vectors. The kits provide ... reagents, insert size screening system) necessary to ...
ID clarifier: Without ethidium bromide...
... Acridine orange has been used as a ... and polyacrylamide gels. Acridine orange at a ... DNA in gels with a sensitivity of ... been used extensively for cell staining of ...
... rich in GC content or with significant ... amplify, and when subjected to PCR result ... and consistency can be increased by the ... reactions. Polymer-Aide is an effective PCR enhancer ...
Biology Products: