Navigation Links
Researchers at UGent and VIB, discovered potential novel treatment against septic shock
Date:2/7/2014

Septic shock is caused by excessive and systemic reaction of the entire body against infectious agents, in most cases of bacterial origin. The number of deaths by septic shock in intensive care units is very high and is still increasing, despite numerous large scale clinical trials. Scientists of VIB and UGent, supervised by Peter Vandenabeele, demonstrated in a mouse study that a potential novel treatment for sepsis may consist of the simultaneous neutralization of two harmful cytokines in the blood circulation, namely interleukin-1 and interleukin-18.

In the VIB research unit of Peter Vandenabeele, postdoctoral researcher Tom Vanden Berghe, in collaboration with Anje Cauwels, discovered a novel potential treatment for sepsis based on a combination strategy. The study was performed in mice and revealed that it is crucial to neutralize two harmful cytokines in the blood circulation simultaneously, more specifically interleukin-1 and interleukin-18. Neutralization of interleukin-1 is currently being used for the treatment of acute rheumatoid arthritis, while neutralization of interleukin-18 has been proposed for the treatment of several other inflammatory diseases.

Peter Vandenabeele (VIB/UGent): "Hitting one target is not sufficient. Biology is full of pleiotropy and synergism, also in diseases. Hitting multiple targets, also in septic shock, may be the way to go".

The application of the novel combined therapy for the treatment of septic patients in the hospital may benefit from the fact that each of those anti-cytokine treatments is already in clinical use. This may create renewed hope for the fight against this life-threatening disease, which is still increasing due to antibiotic-resistant bacteria as well as the growing number of patients whose immune system is weakened by disease or therapy (for example cancer, auto-immune diseases, organ transplantation, and diabetes).

These new findings strengthen our growing awareness that in complex diseases like sepsis it may not be sufficient to neutralize one mediator, but that combination strategies may be essential to increase the chance for successful therapy. The researchers hope that the efficiency of this novel combined therapy in patients may be explored in the future, with the help of pharmaceutical industry and clinical testing.


'/>"/>

Contact: Kris Van der Beken
info@vib.be
32-924-46611
VIB (the Flanders Institute for Biotechnology)
Source:Eurekalert

Related biology news :

1. Grant to help researchers find leukemias hiding places
2. Researchers discover rare new species of deep-diving whale
3. Presence of humans and urban landscapes increase illness in songbirds, researchers find
4. Researchers build 3-D structures to test breast cancer treatments
5. New hope: Researchers discover genetic mutations that cause rare and deadly lung disease
6. Stanford researchers discover how brain regions work together, or alone
7. Researchers identify 9 steps to save waterways
8. Zebra fish fins help Oregon researchers gain insight into bone regeneration
9. Researchers reverse some lung diseases in mice by coaxing production of healthy cells
10. CU-Boulder researchers sequence worlds first butterfly bacteria, find surprises
11. Dartmouth researchers develop new tool to identify genetic risk factors
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/13/2017)... Calif. , April 13, 2017 UBM,s ... York will feature emerging and evolving technology ... Both Innovation Summits will run alongside the expo portion ... speaker sessions, panels and demonstrations focused on trending topics ... largest advanced design and manufacturing event will take place ...
(Date:4/11/2017)... -- Research and Markets has announced the addition of ... offering. ... market to grow at a CAGR of 30.37% during the period ... has been prepared based on an in-depth market analysis with inputs ... growth prospects over the coming years. The report also includes a ...
(Date:4/6/2017)... , April 6, 2017 ... RFID, ANPR, Document Readers, by End-Use (Transportation & Logistics, ... Facility, Oil, Gas & Fossil Generation Facility, Nuclear Power), ... Educational, Other) Are you looking for a ... sector? ...
Breaking Biology News(10 mins):
(Date:10/11/2017)... Charlotte, N.C. (PRWEB) , ... October 11, 2017 ... ... ARCS® Foundation President Andi Purple announced Dr. Suneel I. Sheikh, the ... Laboratories ( ASTER Labs ), Inc. has been selected for membership in ...
(Date:10/11/2017)... BALTIMORE, Md. (PRWEB) , ... October 11, 2017 ... ... for digital pathology, announced today it will be hosting a Webinar titled, “Pathology ... of  Advanced Pathology Associates , on digital pathology adoption best practices and how ...
(Date:10/11/2017)... Austin, TX (PRWEB) , ... October 11, 2017 ... ... in August compared the implantation and pregnancy rates in frozen and fresh ... the contribution of progesterone and maternal age to IVF success. , After comparing ...
(Date:10/10/2017)... (PRWEB) , ... October 10, 2017 , ... ... Science Center’s FirstHand program has won a US2020 STEM Mentoring Award. Representatives of ... award for Excellence in Volunteer Experience from US2020. , US2020’s mission is to ...
Breaking Biology Technology: