Navigation Links
Researchers at Penn help develop a dynamic model of tissue failure
Date:12/12/2013

r surrounding environment. Much of this behavior is due to myosin activity. Myosin is a molecular motor protein that helps muscles contract, but it is present in most types of cells, as it helps them to divide and anchor themselves to one another.

To flesh out their understanding of myosin's role in tissue stability, the researchers performed a series of physical experiments, growing heart tissue samples under various mechanical constraints while chemically altering their myosin activation.

The researchers used rapid prototyping to build "dogbone" shaped environments for the tissues to grow in. The shape, two ring-shaped wells connected by a narrow bridge, was ideal for testing mechanical properties of the cells because it forced them to stretch instead of contracting in on themselves.

The researchers also fluorescently labeled the cells so they could measure the degree to which they were stretching. They saw cells in the middle of the "bone" grow up to thirty times longer than normal, a factor that led to the tissue's ultimate demise.

"Over the course of 30 hours or so, the cells pull on one another until the middle of the bone breaks. A similar process happens in each of the rings afterwards as well," Shenoy said. "You can't really hold the tissue and have it stable in this shape. It will find a way to pull, due to the myosin in the cells, and this leads to a major morphological instability."

The researchers knew myosin was responsible for this instability because when they treated the tissue samples with a drug that inhibits the protein's activation, the tissues didn't break. The protein transforming growth factor beta, a protein that is a factor in scarring and tumor progression, had the opposite effect on myosin, causing the tissues to break faster.

The researchers used a different experimental set-up to test another factor that could impact myosin activity: how strongly the cells are able to pul
'/>"/>

Contact: Evan Lerner
elerner@upenn.edu
215-573-6604
University of Pennsylvania
Source:Eurekalert  

Page: 1 2 3 4

Related biology news :

1. Leibniz Prizes 2014: DFG honors 11 outstanding researchers
2. Researchers named to National Academy of Inventors
3. Researchers at Penn show optimal framework for heartbeats
4. University researchers observe surprising bonefish spawning behavior in the Bahamas
5. ASU researchers discover chameleons use colorful language to communicate
6. Canadian researchers lead groundbreaking discovery in deadly childhood cancer
7. Mount Sinai researchers say new strain of bird flu packs a punch even after becoming drug-resistant
8. Researchers develop worlds highest quantum efficiency UV photodetectors
9. Researchers develop system for assessing how effective species are at pollinating crops
10. UF researchers experiment is first to simulate warming of Arctic permafrost
11. Rensselaer researchers to map step-by-step mechanism of photosynthesis
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Researchers at Penn help develop a dynamic model of tissue failure
(Date:10/1/2014)... Reserve University researchers hope to take a healthy salad ... aggressive form of breast cancer in leafy greens. , ... the vaccine either by eating the salad or making ... assistant professor of biomedical engineering at Case Western Reserve ... The Susan G. Komen breast cancer organization is funding ...
(Date:10/1/2014)... 2014 Novel detection technology ... field  The life science field has ... the years. Some are shooting stars and others ... novel detection technology that has raised much enthusiasm ... technology is becoming commercially available. With their unique ...
(Date:9/30/2014)... visit the Mediterranean each year, but its deep-blue ... Earth. Almost 1,000 alien species, including fish, crustaceans, ... through human activities. In the open-access journal ... of researchers analyzed data from a new information ... how the introduction of alien species has changed ...
Breaking Biology News(10 mins):Scientists wield plant viruses against deadly human disease 2Scientists wield plant viruses against deadly human disease 3First-of-a-kind Solution for Utilizing Photon Upconversion 2Biodiversity in the Mediterranean is threatened by alien species 2
... bacteria that break down pollutants do their job and ... toxic wastes. , Bacteria called Dehalococcoides ethenogenes, discovered in ... professor of civil and environmental engineering, and isolated and ... now in wide use to detoxify such carcinogenic chemicals ...
... announced the publication in the June 23 issue of the ... gene therapy trial for Parkinson’s disease and the first report ... for any adult neurodegenerative disease. , The open label ... disease demonstrated both a lack of adverse events related to ...
... in the United States and other northern mid- ... in offsetting global warming than previously thought, according ... The study, which sheds light on the so-called ... are removing an unexpectedly high proportion of carbon ...
Cached Biology News:Helping chlorine-eating bacteria clean up toxic waste 2Gene therapy study shows safety and statistically significant improvement in Parkinson's disease 2Gene therapy study shows safety and statistically significant improvement in Parkinson's disease 3Gene therapy study shows safety and statistically significant improvement in Parkinson's disease 4Scientists close in on missing carbon sink 2Scientists close in on missing carbon sink 3
(Date:10/1/2014)... 30, 2014 Today the National ... of grants for the Brain Research through Advancing ... to develop and revolutionize new methods of understanding ... human brain. This first round of grants totaling ... was allocated to more than 100 investigators in ...
(Date:10/1/2014)... TeselaGen Biotechnology has received ... expand their bioCAD/CAM software suite, which uses synthetic ... Small Business Innovation Research Phase II grant will be ... license from the Lawrence Berkeley National Laboratory. j5 was ... LBNL laboratory that develops alternative fuel technologies for the ...
(Date:9/30/2014)... 30, 2014 Applying a well-known optical phenomenon ... Harvard University has demonstrated the ability to "paint" ... that holds promise for making future, flexible electronic ... sides of next-gen rocket ships and spacecraft with ... through oil in water, it becomes iridescent, revealing ...
(Date:9/30/2014)... Shimadzu Scientific Instruments has released the DSES-1000 long-travel ... for measuring displacement in rubber and other soft ... distance, the DSES-1000 can measure elongations up to ... mm. In addition, it achieves +/- 0.2 percent ... +/- 100 µm below 50-mm stroke. , The ...
Breaking Biology Technology:NIH Awards 15 Grants to CHI Members for BRAIN Initiative Research 2NIH Awards 15 Grants to CHI Members for BRAIN Initiative Research 3TeselaGen Receives $750k NSF SBIR Phase II Award 2TeselaGen Receives $750k NSF SBIR Phase II Award 3Taking thin films to the extreme 2Shimadzu’s New Long-Travel Extensometer Increases Precision for Soft Material Testing 2
... the pro and cons of radio frequency identification technology ... at the second annual Wisconsin RFID Conference. Sponsored by ... at the steps for implementing RFID and predicted where ... about a product in an electronic tag. The tags ...
... MILWAUKEE - Metavante Corporation , a supplier of ... Corporation , has acquired two financial firms located in Virginia ... purchased GHR Systems , a provider of loan origination ... million and the deal is expected to close in the ...
... Wis. - It would be misleading to suggest that ... human embryos. They arent. In fact, no scientist in the ... ,It would also be disingenuous to suggest the process for ... at the outset -- from the process used in ...
Cached Biology Technology:Conference studies applications and lessons of RFID 2Conference studies applications and lessons of RFID 3The Attack of the Clones: No, its not a summer movie 2The Attack of the Clones: No, its not a summer movie 3
... plus assay system offers the ... Designed for batch-processing systems, Long ... density microplates such as 384-well ... Convenient storage conditions ( 2 ...
Sf21 cells derived from Spodoptera frugiperda ovarian cells are recommended for high-level production of recombinant proteins. Higher expression levels of some proteins are seen due to the larger ce...
... steadylite plus assay system offers ... sensitivity, Designed for batch-processing systems, ... higher density microplates such as ... free, Convenient storage conditions ( ...
Sf9 cells derived from Spodoptera frugiperda ovarian cells (Sf21 cells) are commonly used to isolate and propagate recombinant AcMNPV viral stocks and to produce recombinant proteins....
Biology Products: