Navigation Links
Researchers at IRB Barcelona discover a general mechanism that accelerates tumor development
Date:2/24/2013

Cancer is characterized by uncontrolled cell division and growth. In order to identify new therapeutic targets through which to tackle the disease, scientists seek to clarify the mechanisms that control the expression of genes that favor the development of tumors, in processes such as uncontrolled cell division. Today, Nature has published a paper by the lab headed by Ral Mndez, ICREA professor at the Institute for Research in Biomedicine (IRB Barcelona). The study describes a mechanism controlled by the CPEB1 protein that affects more than 200 genes related to cell proliferation and tumor progression. The mechanism, which was discovered using Hodgkin lymphoma cells, has been proposed as a general regulatory system that enhances the spread of cancer.

The researchers describe that CPEB1 shortens a highly specific region of RNAs (RNAs are the molecules that carry gene information for protein synthesis). This region holds most of the signals that determine whether an RNA molecule is made into a protein or not. "CPEB1 "takes off the brakes" for hundreds of RNAs that stimulate cell desdifferentiation and proliferation, allowing them to be made into proteins; however, in addition to removing the brakes in the nucleus, this protein accompanies RNA to the cytoplasm, where it speeds up the production of these proteins", explains the senior author of the paper Ral Mndez, head of the "Translational control of cell cycle and differentiation" group at IRB Barcelona.

Ral Mndez is an expert on the CPBE protein family, a type of RNA-binding protein that has a positive and crucial role in early embryo development. "CPEB proteins are necessary during development and also during tissue regeneration via stem cells in adults, but if the programme governed by CPEBs is continually switched on, cells divide when they are not supposed to and form a tumor", explains Mndez. The CPEB family comprises four proteins, which compensate each other's normal function bu
'/>"/>

Contact: Snia Armengou
armengou@irbbarcelona.org
34-934-037-255
Institute for Research in Biomedicine (IRB Barcelona)
Source:Eurekalert  

Page: 1 2 3

Related biology news :

1. Brown University researchers build robotic bat wing
2. Researchers say sunlight yields more efficient carbon dioxide to methanol model
3. Researchers decipher modus operandi of potential Alzheimers drug
4. Stanford researchers develop tool for reading the minds of mice
5. Researchers in Manchester find genetic key to preventing spine tumors
6. When It Comes To Genetic Code, Researchers Prove Optimum Isnt Always Best
7. UTSW researchers identify new enzyme that acts as innate immunity sensor
8. Researchers make racehorses fertile
9. USC researchers find possible genetic clues to organ development, birth defects
10. Researchers discover Achilles heel for lymphoid leukemia
11. Researchers find Asian needle ants displacing other aggressive invaders
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Researchers at IRB Barcelona discover a general mechanism that accelerates tumor development
(Date:7/21/2014)... Irvine, Calif., July 21, 2014 Dysfunction in ... about 2,000 genes in the brain,s prefrontal cortex ... complex neuropsychiatric disorders, such as schizophrenia, according to ... gene activity in brain cells that receive this ... deficiencies can affect a variety of behavioral and ...
(Date:7/21/2014)... satellites detected 154 hotspots in areas across Riau province ... had increased again following a decline in rainfall. ... far higher than what had been reported one day ... hotspots were scattered in six regencies and municipalities, most ... and the related haze it creates could potentially spread ...
(Date:7/21/2014)... change, due to greenhouse gasses emitted by livestock. New ... and that beef cattle are responsible for far more ... is published by Climactic Change . , ... to climate change. It is released by vehicles, industry, ... greenhouse gas totals. But methane and nitrous oxide are ...
Breaking Biology News(10 mins):UCI researchers find epigenetic tie to neuropsychiatric disorders 2Climate: Meat turns up the heat 2
... with a large-scale "geoengineering" fix, such as having a ... or building tens of millions of chemical filter systems ... But Richard Turco, a professor in ... a member and founding director of UCLA,s Institute of ...
... Rochester have designed a gene that produces a ... in healthy cells., The findings may help address ... ability to specifically and effectively target cancer cells. ... to insert "self-destruct" codes into the modified gene, ...
... Commonwealth University Life Sciences survey shows that eight in 10 ... who want it, and 54 percent say that the benefits ... about genetic research are varied with a plurality of 38 ... known about how to conduct such research safely. About three ...
Cached Biology News:No quick or easy technological fix for climate change, researchers say 2No quick or easy technological fix for climate change, researchers say 3No quick or easy technological fix for climate change, researchers say 4Modified gene targets cancer cells a thousand times more often than healthy cells 2Modified gene targets cancer cells a thousand times more often than healthy cells 3VCU survey: US public supports genetic research, testing and government spending on research 2VCU survey: US public supports genetic research, testing and government spending on research 3
(Date:7/21/2014)... a chain of carbon atoms can turn it from ... University scientists. , Stretching the material known as carbyne ... by just 3 percent can begin to change its ... mechanically activated nanoscale electronics and optics. , The finding ... appears in the American Chemical Society journal Nano ...
(Date:7/21/2014)... 21, 2014 Sleep disturbances such ... closely correlated with depression. According to a study ... "About three quarters of depressed patients have insomnia ... of young depressed adults and 10% of older ... cause huge distress, have a major impact on ...
(Date:7/18/2014)... , July 18, 2014  Neogen Corporation (Nasdaq: ... , Neogen,s chief operating officer and president, has resigned, ... work as a consultant going forward on special projects. ... has been in this position since September 2013. On ... James Herbert , who has been Neogen,s chief ...
(Date:7/18/2014)... Cambridge, MA (PRWEB) July 18, 2014 ... in Budapest with US offices in Cambridge, MA, ... a combination Assay and Software product that leverages ... use on the Illumina® MiSeq sequencing platform. The ... with The Children’s Hospital of Philadelphia (CHOP) and ...
Breaking Biology Technology:Carbyne morphs when stretched 2Carbyne morphs when stretched 3Open Label Data on Enhanced Sleep Released by JayMac Pharmaceuticals, LLC 2Open Label Data on Enhanced Sleep Released by JayMac Pharmaceuticals, LLC 3Omixon Launches Holotype HLA for NGS-based HLA Genotyping 2Omixon Launches Holotype HLA for NGS-based HLA Genotyping 3
... , , , Multiporator , , , , , ... Transfection Protocol , Protocol No. 4308 915.026 11/2001 , ... , , , ... line), , , ...
... , , , Multiporator / Electroporator 2510 , , , , , ... Transformation Protocol , Protocol No. 4308 915.525 01/2002 , ... , , , ... , Cell type , Bacteria, gram positive, ...
... Multiporator / Electroporator 2510 , , , , , , , ... Protocol No. 4308 915.540 07/2002 , , ... , , Microorganism , ... Cell type , Bacteria, gram positive, , ...
Cached Biology Technology:Sp20-Ag14 2Sp20-Ag14 3Nocardia asteroides 2Pediococcus spp. 2
... CHEMICON's Cell Transformation Detection Assay is an ... is considered the most stringent assay for ... this assay, cells (pre-treated with carcinogens or ... in soft agar medium for 21-28 days. ...
The Saturn 2200 answers your GC/MS questions with the CP-3800 GC and the 2000 Series Ion Trap MS! These components create a platform for the worlds most versatile GC and flexible MS. Both deliver une...
... Kit uses a simplified procedure and streamlines ... The kit is based on the three ... and sodium bisulfite where cytosine is converted ... innovative in-column desulphonation reaction eliminates several precipitation ...
... Invitrogen makes blotting of E-PAGE Gels ... pre-cut fiber blotting pad and several types ... perfectly fit 8.6 cm x 13.5 cm ... PVDF membranes are designed for western transfer ...
Biology Products: