Navigation Links
Researchers at GIS develop systematic approach for accurate DNA sequence reconstruction
Date:12/5/2011

Researchers at the Genome Institute of Singapore (GIS) have, for the very first time, developed a computational tool that comes with a guarantee on its reliability when reconstructing the DNA sequence of organisms, thus enabling a more streamlined process for reconstructing and studying genomic sequences.

The work, lead by Dr Niranjan Nagarajan, Assistant Director of Computational and Mathematical Biology at the GIS, was reported in the November 2011 issue of the Journal of Computational Biology.

The genomic study of life (plants and animals alike) is based on computational tools that can first piece together the DNA sequence of these organisms, a process called genome assembly, that is similar to solving a giant puzzle or putting together the words in a book from a shredded copy. Due to the sheer scale of this challenge, existing approaches for genome assembly rely on heuristics and often result in incorrect reconstructions of the genome. The work reported here represents the first algorithmic solution for genome assembly that provides a quality guarantee and scales to large datasets. A new and improved implementation for this algorithm called Opera is now freely available at http://sourceforge.net/projects/operasf/ and has been used at the GIS for successfully assembling large plant and animal genomes.

The assembled genome of an organism forms the basis for a range of downstream biological investigations and serves as a critical resource for the research community. The draft human genome, for example, was obtained at the expense of billions of dollars, serves as a fundamental resource for biomedical research and is, in fact, still being refined. Improved assembly tools thus serve to generate the most complete and accurate draft genomes that can be reconstructed from the data, avoiding mis-assembly related dead-ends for downstream research as well as minimizing the painstaking effort needed to refine and correct a draft assemb
'/>"/>

Contact: Winnie Serah Lim (Ms)
limcp2@gis.a-star.edu.sg
65-680-88013
Agency for Science, Technology and Research (A*STAR), Singapore
Source:Eurekalert

Page: 1 2

Related biology news :

1. 2 top biological imaging centers offer powerful free online tool to researchers and public
2. Adult stem cells use special pathways to repair damaged muscle, MU researchers find
3. Medical researchers in Canada and the US discover hidden side of prion diseases
4. Yale researchers develop a way to monitor engineered blood vessels as they grow in patients
5. NJIT researchers publish news of success with robots as learning tool
6. Researchers new recipe cooks up better tissue phantoms
7. BUSM researchers develop blood test to detect membranous nephropathy
8. WSU researchers use a 3-D printer to make bone-like material
9. Abstinence-only education does not lead to abstinent behavior, UGA researchers find
10. Body rebuilding: Researchers regenerate muscle in mice
11. UCLA researchers engineer blood stem cells to fight melanoma
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:11/7/2014)... professor, biomedical engineering, in the Grove School of ... have identified a molecule that could lead to ... forms of breast cancer. , Triple negative breast ... to aggressive proliferation and metastasis and a lack ... discovered the overexpression of intercellular adhesion molecule-1 (ICAM-1) ...
(Date:11/6/2014)... TALLAHASSEE, Fla. -- A groundbreaking paper from a team ... better understanding of how plants could adapt to and ... The research, published in the latest issue of the ... how chromatin (the complex of DNA and proteins) is ... material, so that some genes are turned on and ...
(Date:11/6/2014)... - Insilico Medicine, Inc, a Baltimore-based bioinformatics company ... diseases announced a research collaboration with the international ... Inc (OTC: CSBR). , "There are many companies ... Champions Oncology,s TumorGraft technology is unique in a ... experimentally generating vast amounts of valuable data. Our ...
Breaking Biology News(10 mins):Maize analysis yields whole new world of genetic science 2Insilico Medicine, Inc announces research collaboration with Champions Oncology, Inc 2
... therapy currently used to treat Helicobacter pylori (H. ... disorders, is unsuccessful in around 25 percent of ... Journal of Gastroenterology, finds that adding a bovine ... yield more effective results, with fewer of the ...
... true spontaneity exist ?in fruit flies. This is what ... 16, 2007 issue of the open-access journal PLoS ONE. ... complex robots which only respond to external stimuli," says ... They are assumed to be input-output devices. "When scientists ...
... but don’t count on them to prevent prostate ... Epidemiology, Biomarkers & Prevention, researchers based at the ... Center report that lycopene, an antioxidant predominately found ... In fact, the researchers noted an association ...
Cached Biology News:Do fruit flies have free will? 2No magic tomato? Study breaks link between lycopene and prostate cancer prevention 2
(Date:11/26/2014)... (PRWEB) November 25, 2014 Whitehouse ... officially joined the Morris County (New Jersey) Chamber ... is a leading business organization in the North ... to further engage some key clients in the ... in the geographic area. Membership enables Whitehouse Laboratories ...
(Date:11/26/2014)... Pittsburgh, PA (PRWEB) November 25, 2014 ... release of its official conference and exposition mobile app, ... available for free download in the App Store for ... as a valuable resource tool before, during and after ... guide containing details on exhibiting companies, technical sessions, Conferee ...
(Date:11/26/2014)... 26, 2014 CURE™ magazine ... on December 5, 2014, in San Francisco prior to ... Heroes event will honor clinicians, caregivers, and advocates who ... neoplasms (MPNs). , Special guest speaker Charles Esten, ... cancer journey at the reception. Over a decade ...
(Date:11/26/2014)... /PRNewswrie/ -- Theravalues Corporation annuncia con orgoglio il lancio ... di Hi Europe 2014 (dal 2 al 4 dicembre, ... della curcumina con la maggiore biodisponibilità di sempre, con ... approvati dalle norme europee. La curcumina è ... ( Curcuma longa ) che è stata associata con ...
Breaking Biology Technology:Whitehouse Laboratories Joins Morris County Chamber of Commerce 2Whitehouse Laboratories Joins Morris County Chamber of Commerce 3Pittcon Releases 2015 Mobile App 2CURE Magazine and Incyte to Honor MPN Heroes 2CURE Magazine and Incyte to Honor MPN Heroes 3CURE Magazine and Incyte to Honor MPN Heroes 4La curcumina con la maggiore biodisponibilità di sempre farà il suo debutto in Europa 2La curcumina con la maggiore biodisponibilità di sempre farà il suo debutto in Europa 3
... a privately-held biotech company using its proprietary platform technology ... gastrointestinal diseases, announced today that it has elected Christopher ... Inc. to its Board of Directors. ... on our Board," said Dr. Barbara Fox, founder, CEO ...
... Inc. (Nasdaq: SGMO ) today announced that the ... Wednesday, May 2, 2012, after the market closes. The press ... p.m. ET, which will be open to the public via ... review the financial results and discuss other business matters. ...
... 2012 The rise of the corporate ... investing are emerging key themes at BioTrinity, the-premier European ... business network which provides comprehensive support for bioscience businesses ... The first day of the conference saw ...
Cached Biology Technology:Avaxia Biologics Elects Christopher Kiritsy to its Board of Directors 2Sangamo BioSciences Announces First Quarter 2012 Conference Call and Webcast 2Corporate Venturing and Early-Stage Financing in the Spotlight at BioTrinity 2Corporate Venturing and Early-Stage Financing in the Spotlight at BioTrinity 3
... provides a convenient method to probe conformational changes ... substrates. Thus, the kit may be used to ... as transport substrates for MDR1. Because UIC2 binding ... substrates, the MDR1 Shift Assay can be utilized ...
... wide and long electrophoresis hood ... gel documentation systems. Placed on ... camera in place and provides ... photography on the lab bench. ...
... Zyagen tissue microarrays are derived from Paraffin ... rigorous quality control procedures to ensure the ... manually assembled in one block, sectioned at ... on coated slides. Sections are large (3-5 ...
... from frozen embedded tissue blocks, which are ... ensure the highest quality. Tissues of each ... sectioned at a thickness of 7microns and ... (3-5mm in diameter) in comparison to core ...
Biology Products: