Navigation Links
Researchers at Children's Hospital Los Angeles find diet-induced obesity accelerates leukemia
Date:9/7/2010

LOS ANGELES (September 7, 2010) The first study to demonstrate that obesity can directly accelerate the progression of acute lymphoblastic leukemia (ALL) has been conducted at The Saban Research Institute of Childrens Hospital Los Angeles and will be published in Cancer Prevention Research, on October 5, 2010. Obesity has been associated with an increased incidence of many cancers, including leukemia, but it has been unknown whether the increase in incidence was a direct effect of obesity or associated with genetic, lifestyle, health, or socio-economic factors.

"Given the high prevalence of obesity in our society, we felt it was critical to determine if obesity actually caused the increased incidence of leukemia and not some other associated exposure," explains Steven D. Mittelman, MD, PhD, a pediatric endocrinologist who led the study.

Dr. Mittelman and his colleagues used a high-fat diet to induce obesity in two mouse models of ALL. Mice were randomized to a high-fat or a control diet. The investigators found that obesity increased the risk of ALL in both models, particularly in older mice. This observation was consistent with the type of cumulative effect seen with other exposure-related cancers, such as lung cancer related to smoking and breast cancer resulting from increased estrogen exposure. Observing the difference in older animals also agreed with the other obesity-related effects from cumulative exposure such as heart disease, diabetes, and arthritis.

"Our findings are consistent with epidemiological data that show a higher incidence of leukemia in obese adults and suggests that these observations are actually due to obesity, and not some associated genetic, socio-economic, or lifestyle factor," concluded Dr. Mittelman, who is also an Assistant Professor of Pediatrics and Physiology & Biophysics at the Keck School of Medicine of the University of Southern California. "These data imply that some hormone or factor in overweight individuals, perhaps produced by fat tissue itself, may signal leukemia cells to grow and divide. Since leukemia is the most common type of childhood cancer, understanding how obesity may increase its incidence could have important public health implications."


'/>"/>

Contact: CONTACT: Ellin Kavanagh
ekavanagh@chla.usc.edu
323-361-8505
Children's Hospital Los Angeles
Source:Eurekalert

Related biology news :

1. Researchers define role of CEP290 in maintaining ciliary function
2. Research about Brazilian marine biodiversity brings researchers from 5 countries together
3. Researchers identify how bone-marrow stem cells hold their breath in low-oxygen environments
4. Bochums researchers discover proton diode
5. U-M researchers receive largest single collection of psoriasis DNA samples
6. Researchers analyze the environmentalists paradox
7. Researchers develop simulation to better understand the effects of sound on marine life
8. U of Alberta researchers discover important mechanism in fighting infection
9. UBC researchers unveil toolbox of MiniPromoters for gene research and therapy
10. Researchers to activate anti-cancer gene
11. ISU researchers develop hybrid protein tools for gene cutting and editing
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/1/2016)... 2016 Rising sales of consumer ... touchfree intuitive gesture control market size ... of consumer electronics coupled with new technological advancements to ... size through 2020   --> ... technological advancements to drive global touchfree intuitive gesture control ...
(Date:1/25/2016)... Unisys Corporation (NYSE: UIS ) today announced the implementation ... New York City , to help U.S. ... the United States using passports that are ... of the system at Dulles last year. The system will ... 2016. --> pilot testing of the system at ...
(Date:1/20/2016)... 2016 A market that just keeps on ... the explosion in genomics knowledge. Learn all about it ... range of dynamic trends are pushing market growth and ... - pharmacogenomics - pathogen evolution - next generation sequencing ... greater understanding of the role of genetic material in ...
Breaking Biology News(10 mins):
(Date:2/10/2016)... , Feb. 10, 2016  The Maryland House ... , has announced that University of Maryland School of ... MBA and University of Maryland Medical System President and ... the "Speaker,s Medallion," the highest honor given to the ... Delegates. Dean Reece and Mr. Chrencik ...
(Date:2/10/2016)... , Feb. 10, 2016  Allergan plc (NYSE: ... that Brent Saunders , Allergan,s CEO and President, ... fireside chat session at the RBC Capital Markets Healthcare ... ET at The New York Palace Hotel in ... be webcast live and can be accessed on Allergan,s ...
(Date:2/10/2016)... ... 10, 2016 , ... SonaCare Medical, LLC reports the introduction ... remote monitoring. The inaugural launch of this new technology occurred over the course ... Peretsman to a HIFU technical expert at SonaCare Medical headquarters. , Sonalink ...
(Date:2/10/2016)... ... 2016 , ... Creation Technologies, leading global provider of electronics ... Rating Award from Circuits Assembly , today announced its milestone achievement of ISO ... and China. , The EMS provider, known in the EMS industry for its ...
Breaking Biology Technology: