Navigation Links
Researchers at Children's Hospital Los Angeles find diet-induced obesity accelerates leukemia
Date:9/7/2010

LOS ANGELES (September 7, 2010) The first study to demonstrate that obesity can directly accelerate the progression of acute lymphoblastic leukemia (ALL) has been conducted at The Saban Research Institute of Childrens Hospital Los Angeles and will be published in Cancer Prevention Research, on October 5, 2010. Obesity has been associated with an increased incidence of many cancers, including leukemia, but it has been unknown whether the increase in incidence was a direct effect of obesity or associated with genetic, lifestyle, health, or socio-economic factors.

"Given the high prevalence of obesity in our society, we felt it was critical to determine if obesity actually caused the increased incidence of leukemia and not some other associated exposure," explains Steven D. Mittelman, MD, PhD, a pediatric endocrinologist who led the study.

Dr. Mittelman and his colleagues used a high-fat diet to induce obesity in two mouse models of ALL. Mice were randomized to a high-fat or a control diet. The investigators found that obesity increased the risk of ALL in both models, particularly in older mice. This observation was consistent with the type of cumulative effect seen with other exposure-related cancers, such as lung cancer related to smoking and breast cancer resulting from increased estrogen exposure. Observing the difference in older animals also agreed with the other obesity-related effects from cumulative exposure such as heart disease, diabetes, and arthritis.

"Our findings are consistent with epidemiological data that show a higher incidence of leukemia in obese adults and suggests that these observations are actually due to obesity, and not some associated genetic, socio-economic, or lifestyle factor," concluded Dr. Mittelman, who is also an Assistant Professor of Pediatrics and Physiology & Biophysics at the Keck School of Medicine of the University of Southern California. "These data imply that some hormone or factor in overweight individuals, perhaps produced by fat tissue itself, may signal leukemia cells to grow and divide. Since leukemia is the most common type of childhood cancer, understanding how obesity may increase its incidence could have important public health implications."


'/>"/>

Contact: CONTACT: Ellin Kavanagh
ekavanagh@chla.usc.edu
323-361-8505
Children's Hospital Los Angeles
Source:Eurekalert

Related biology news :

1. Researchers define role of CEP290 in maintaining ciliary function
2. Research about Brazilian marine biodiversity brings researchers from 5 countries together
3. Researchers identify how bone-marrow stem cells hold their breath in low-oxygen environments
4. Bochums researchers discover proton diode
5. U-M researchers receive largest single collection of psoriasis DNA samples
6. Researchers analyze the environmentalists paradox
7. Researchers develop simulation to better understand the effects of sound on marine life
8. U of Alberta researchers discover important mechanism in fighting infection
9. UBC researchers unveil toolbox of MiniPromoters for gene research and therapy
10. Researchers to activate anti-cancer gene
11. ISU researchers develop hybrid protein tools for gene cutting and editing
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/3/2016)... LONDON , June 3, 2016 /PRNewswire/ ... Transport Management) von Nepal ... ,Angebot und Lieferung hochsicherer geprägter Kennzeichen, einschließlich ... weltweit führend in der Produktion und Implementierung ... an der Ausschreibung im Januar teilgenommen, aber ...
(Date:6/2/2016)... June 2, 2016 Perimeter Surveillance ... Unmanned Systems, Physical Infrastructure, Support & Other Service  ... visiongain offers comprehensive analysis of the global ... will generate revenues of $17.98 billion in 2016. ... Inc, a leader in software and hardware technologies for ...
(Date:5/20/2016)... 20, 2016  VoiceIt is excited to announce ... By working together, VoiceIt and VoicePass ... and VoicePass take slightly different approaches to voice ... security and usability. ... new partnership. "This marketing and technology ...
Breaking Biology News(10 mins):
(Date:6/23/2016)... SILVER SPRING, Md. , June 23, 2016 ... evidence collected from the crime scene to track the criminal ... sick, and the U.S. Food and Drug Administration (FDA) uses ... Sound far-fetched? It,s not. ... whole genome sequencing to support investigations of foodborne illnesses. Put ...
(Date:6/23/2016)... 2016  The Biodesign Challenge (BDC), a university competition ... harness living systems and biotechnology, announced its winning teams ... New York City . The ... projects at MoMA,s Celeste Bartos Theater during the daylong ... senior curator of architecture and design, and Suzanne ...
(Date:6/23/2016)... ... , ... In a new case report published today in STEM CELLS Translational ... lymphedema after being treated for breast cancer benefitted from an injection of stem cells ... this debilitating, frequent side effect of cancer treatment. , Lymphedema refers to ...
(Date:6/23/2016)... YORK , June 23, 2016 ... trading session at 4,833.32, down 0.22%; the Dow Jones Industrial ... S&P 500 closed at 2,085.45, down 0.17%. Stock-Callers.com has initiated ... INFI ), Nektar Therapeutics (NASDAQ: NKTR ), ... Therapeutics Inc. (NASDAQ: BIND ). Learn more about ...
Breaking Biology Technology: