Navigation Links
Researchers advance understanding in immune response to infectious disease
Date:7/16/2014

University of Leicester researchers have released evidence substantiating an unexpected dual role of an important component of the immune system.

Findings by researchers at the University's Department of Infection, Immunity and Inflammation including three PhD graduates are published in a paper for the journal 'Medical Microbiology and Immunology'.

The paper presents significant new findings about the protein properdin an important part of the immune system. It is a positive regulator in the alternative pathway of complement activation which means it plays a key part in one of the body's main techniques for tackling infections and foreign bodies known as antigens.

The new findings show that in some situations a lack of properdin can actually have major benefits while in others it can be a big disadvantage.

Using mouse models, the researchers investigated the differences in immune responses between individuals deficient in properdin and those with normal amounts of the protein.

When individuals were infected with Streptococcus pneumoniae - bacteria which can cause sepsis and pneumonia in humans those deficient in properdin had higher survival rates than those with normal levels.

But when individuals were infected with Listeria monocytogenes which cause an infection called listeriosis in humans those deficient in properdin had lower levels of survival.

Cellular analysis by the researchers suggests that properdin-deficiency is likely to cause the body to use more of a type of white blood cell known as M2 macrophages involved in tissue repair rather than M1 macrophages, whose main role is to kill pathogens.

This allowed the researchers to conclude that properdin controls the strength of the body's immune response by affecting the role of macrophages during infection and inflammation.

Principal investigator and corresponding author, Dr Cordula Stover, Senior Lecturer in Immunology at the University's Department of Infection, Immunity and Inflammation, said: "The PhD graduates' projects together elucidate a critically instructive role of an innate immune protein, complement properdin, in shaping the inflammatory response.

"The work is the first to show that complement properdin controls the strength of immune responses by affecting humoral as well as cellular phenotypes during acute bacterial infection and ensuing inflammation."

Dr Stover also stresses that using mouse models can be very useful for understanding disease mechanisms but there are limitations with the value of mouse models.

She said: "We are asking mice to react to human pathogens or diseases of significance for man, not mouse. Mice are genetically homogenous, unlike man, and have comparable, not identical, scope of cells and antibodies.

"To be meaningful, disease concepts need to be tested in patient samples, in order to have direct application of the research."


'/>"/>

Contact: Cordula Stover
cms13@le.ac.uk
01-162-525-032
University of Leicester
Source:Eurekalert

Related biology news :

1. Study by UC Santa Barbara researchers suggests that bacteria communicate by touch
2. UC Santa Barbara researchers discover genetic link between visual pathways of hydras and humans
3. Researchers attempt to solve problems of antibiotic resistance and bee deaths in one
4. UNH researchers find African farmers need better climate change data to improve farming practices
5. Ottawa researchers to lead world-first clinical trial of stem cell therapy for septic shock
6. Researchers uncover molecular pathway through which common yeast becomes fungal pathogen
7. Researchers print live cells with a standard inkjet printer
8. Columbia Engineering and Penn researchers increase speed of single-molecule measurements
9. Researchers reveal how a single gene mutation leads to uncontrolled obesity
10. Researchers discover novel therapy for Crohns disease
11. New paper by Notre Dame researchers describes method for cleaning up nuclear waste
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/20/2017)... HANOVER, Germany , March 20, 2017 At ... Hamburg -based biometrics manufacturer DERMALOG. The Chancellor came to the ... Japan is this year,s CeBIT partner country. At the largest ... important biometrics in use: fingerprint, face and iris recognition as well as ... ...
(Date:3/9/2017)... FRANCISCO and MOUNTAIN VIEW, Calif. ... , "Eating Well Made Simple," and 23andMe , ... help guide better food choices.  Zipongo can now provide ... their food preferences, health goals and biometrics, but also ... certain food choices. Zipongo,s personalized food decision ...
(Date:3/2/2017)... 2017 Summary This report provides ... KGaA and its partnering interests and activities since 2010. ... Description The Partnering Deals and Alliance since 2010 report ... one of the world,s leading life sciences companies. ... to ensure inclusion of the most up to date ...
Breaking Biology News(10 mins):
(Date:3/22/2017)... Florida , March 22, 2017 ... ... various cancer conditions are being pressured as of late due ... for cancer pain management has a dramatic impact on patient,s ... research and development activities for identifying new forms of opioid ...
(Date:3/22/2017)... ... ... Premier executive recruitment firm, Slone Partners, is proud to have been named ... , Hunt Scanlon Media is one of the most respected life science publications ... human capital sector. , “It is a great honor for Slone Partners to be ...
(Date:3/22/2017)... (PRWEB) , ... March 21, 2017 , ... ... Kickstarter , more than tripling its goal and raising over $30,000 in the ... garden that grows nutritious veggies & herbs fast, easy, and affordably, anywhere. , ...
(Date:3/22/2017)... WI (PRWEB) , ... March 22, 2017 , ... The ... scientific research agencies as outlined in the Administration’s recently published fiscal year 2018 budget ... the National Institutes of Health (NIH) by $5.8 billion or roughly 20% of its ...
Breaking Biology Technology: