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Researchers achieve a full film frame of a family of proteins essential for cell function
Date:2/23/2011

om the extracellular environment. With this new structure, they have completed the film frame that comprises the distinct conformations of these transporters, from when they bind to a molecule until its release in inside the cell and the start of the whole process again with another molecule.

"Now we have a complete register of the events, although with different transporter proteins", explains Palacn. "The future lies in revealing the complete film of each of these proteins. This knowledge will help us to understand diseases such as cistinuria and to design drugs that inhibit the uptake of amino acids by cancer cells and thus affect the viability of these cells".

The study has been headed by IRB Barcelona researchers Manuel Palacn and Jos Luis Vzquez (investigator ICREA), in collaboration with the labs run by Ignasi Fita and Modesto Orozco, both at the same institute, and researchers at the Centro de Investigacin Biomdica en Red de Enfermedades Raras (CIBERER) and the University of Barcelona. The article has been published in today's issue of Proceedings of the National Academy of Sciences of the United States of America (PNAS).


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Contact: Nuria Noriega
nuria.noriega@irbbarcelona.org
Institute for Research in Biomedicine (IRB Barcelona)
Source:Eurekalert

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