Navigation Links
Researchers achieve a full film frame of a family of proteins essential for cell function
Date:2/23/2011

Researchers at IRB Barcelona have completed the 3D structural sequence adopted by several essential proteins in the exchange of substances between the extra and intracellular milieu. This finding provides a global perspective of the structural changes that occur in these relevant proteins during basic cell processes, such as protein synthesis, the regulation of metabolism and cell volume, and nerve transmission.

The exchange of substances between the intra and extra cellular environment is performed by transporter proteins located in cell membranes. These proteins act as selective gates, allowing substances to pass through depending on cell requirements. In humans, transporters like LAT and CAT are particularly relevant as they mediate amino acid transport and are crucial in intestinal absorption and renal reabsorption, protein synthesis, the maintenance of antioxidants, and infection produced by the virus associated with Kaposi sarcoma. According to Manuel Palacn, one of the project coordinators, 300 transporter mutations have been identified in diseases. Consequently, understanding their function is crucial for the development of new pharmacological treatments.

Structural biology as the base from which to study human disease

Having achieved the sequencing of genomes, one of the challenges in biomedicine is to identify the 3D structures of proteins that are crucial for life, such as intra and extracellular transporters. LATs and CATs move within cell membranes, adopting distinct conformations that allow the passage of molecules across the membrane. In this study the scientists have addressed the distinct conformations of the AdiC transporter, a model protein for the study of human LAT and CAT and present in the bacteria Escherichia coli.

By generating crystals of an AdiC variant (mutant N101A) and later X-ray study, researchers have determined for the first time the 3D structures of this protein when binding a molecule fr
'/>"/>

Contact: Nuria Noriega
nuria.noriega@irbbarcelona.org
Institute for Research in Biomedicine (IRB Barcelona)
Source:Eurekalert

Page: 1 2

Related biology news :

1. Researchers find local wildlife protection safeguards entire range
2. Stanford researchers develop new technology for cheaper, more efficient solar cells
3. Tip sheet: Caltech researchers presenting at AAAS
4. MU researchers believe discovery could lead to testing that displaces colonoscopies
5. Researchers link gene mutations to Ebsteins anomaly
6. UT researchers link algae to harmful estrogen-like compound in water
7. Ben-Gurion U. researchers develop techniques to manipulate plant adaption in arid climates
8. Jefferson researchers provide genetic evidence that antioxidants can help treat cancer
9. Researchers working toward automating sedation in intensive care units
10. Boston University School of Medicine researchers receive NIMH brain awards
11. Just in time for Valentines Day: UNC researchers identify a gene critical for heart function
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/27/2015)... -- NXT-ID, Inc. (NASDAQ: NXTD ) ("NXT-ID" or ... growing mobile commerce market, announces that its Wocket® Smart ... week of May, 2015 and will be fulfilling all ... Gino Pereira , Chief Executive Officer said, ... Wocket® enters the consumer market. We would like to ...
(Date:4/20/2015)... 20, 2015 The announcement comes ... Glenbeigh Records Management (GRM), Ireland,s foremost ... Bank. Having built up an impressive track record of clients ... player within the records management sector in Dubai ... is GCC staffbase and employ a further eight staff members ...
(Date:4/13/2015)... NEW YORK , April 13, 2015 /PRNewswire/ ... study by TechSci Research, "Global Biometrics Market Forecast & ... to register a CAGR of around 14% till ... various governments for large scale implementation and review ... technology and launch of new products with greater ...
Breaking Biology News(10 mins):Wocket, the Smartest Wallet You Will Ever Own, Announces Shipment to Pre-order Customers 2Wocket, the Smartest Wallet You Will Ever Own, Announces Shipment to Pre-order Customers 3Glenbeigh Records Management Wins Contract With Dubai Islamic Bank 2Glenbeigh Records Management Wins Contract With Dubai Islamic Bank 3Global Biometrics Market to Cross US$ 21 Billion by 2020: TechSci Research 2
... the nation,s amphibians, including frogs, toads and salamanders, are ... at the University of North Carolina at Chapel Hill ... mirror this disturbing national trend. "It,s a steady ... Micancin [mih-CAN-sin], a visiting lecturer and recent Ph.D. graduate ...
... Scientists are making strides toward unraveling the surprisingly complex ... best," according to an article in the current edition ... the weekly newsmagazine of the American Chemical Society, the ... editor, points out that their findings reveal many intriguing ...
... of marine clouds to cool sea surface temperatures could ... oceans. Research, published in Atmospheric Science Letters , ... could give coral a fifty year ,breathing space, to ... the last few decades has been caused by rising ...
Cached Biology News:N.C.'s Southern Cricket Frog populations declining 2Cloud brightening to cool seas can protect coral reefs 2
(Date:5/6/2015)... , May 6, 2015 ... dass das Unternehmen einen mehrjährigen Vertrag mit ... das Unternehmen exklusiv für den Vertrieb der ... S) konventionellen und organischen Wein- und Mosthefestämme ... ab sofort in Kraft. "Quercus ...
(Date:5/6/2015)... 6, 2015 Bone Biologics, Corp., ("Bone Biologics") announced ... Capital, LLC ("Hankey Capital") of Los Angeles, CA. ... use in bone regenerative medicine using the patented recombinant human ... undergoing spinal fusion. Michael Schuler , ... completion of this round of funding which will allow the ...
(Date:5/6/2015)... ANN ARBOR, Mich. , May 6, 2015 /PRNewswire-USNewswire/ ... , CEO will give the keynote address at the ... Annual Meeting in Phoenix, AZ ... entitled "Personalized Medicine: The Odyssey" will focus on the historic ... ten years in shaping our personalized medicine revolution.  Furthermore, ...
(Date:5/6/2015)... , May 6, 2015  Shenzhen Beike ... Beike Biotechnology, the world,s largest stem cell ... mesenchymal stem cell packets containing no less than ... product could significantly reduce the time and cost ... the case of degenerative conditions such as ...
Breaking Biology Technology:Renaissance Yeast Inc. ernennt Quercus Europe, S.L. zum exklusiven Fachhändler für Schwefelwasserstoff-vermeidende Wein- und Mosthefen in Spanien 2Bone Biologics Corp Completes Financing With Hankey Capital, LLC 2Bone Biologics Corp Completes Financing With Hankey Capital, LLC 3Paradigm CEO Dr. Robert Penny Presents Keynote Address at 2015 ISBER Conference 2Paradigm CEO Dr. Robert Penny Presents Keynote Address at 2015 ISBER Conference 3Beike Biotechnology Produces High-dose Adult Stem Cell Packets for Degenerative Conditions 2
... Anadys Pharmaceuticals, Inc. (Nasdaq: ANDS ) announced today ... Conference on Wednesday, November 17, 2010 at 11:30 a.m. EST ... St. Regis New York.  Steve Worland, Ph.D., President and Chief ... and its clinical development programs. The presentation will ...
... Nov. 10, 2010 Dendreon Corporation (Nasdaq: ... completed the submission of the post-approval supplement to ... Morris Plains, New Jersey manufacturing facility. Dendreon is ... manufacture PROVENGE. The standard U.S. Food and Drug ...
... brain ... ... ... are keyed by longUrl, so we need to grab the first one. for (var r in data.results) { first_result ...
Cached Biology Technology:Anadys Pharmaceuticals to Present at the Lazard Healthcare Conference 2Dendreon Submits Post-Approval Supplement to the PROVENGE Biologics License Application for New Jersey Manufacturing Facility 2Neuro-Biotech Corp. Neuroceuticals® : A solution to feed the brain 2Neuro-Biotech Corp. Neuroceuticals® : A solution to feed the brain 3Neuro-Biotech Corp. Neuroceuticals® : A solution to feed the brain 4Neuro-Biotech Corp. Neuroceuticals® : A solution to feed the brain 5Neuro-Biotech Corp. Neuroceuticals® : A solution to feed the brain 6Neuro-Biotech Corp. Neuroceuticals® : A solution to feed the brain 7Neuro-Biotech Corp. Neuroceuticals® : A solution to feed the brain 8
Formulation: Phosphate-buffered saline, pH 7.2, containing 0.09% sodium azide....
... and analysis software for electrophysiology ... Contains powerful stimulus generation capabilities ... including automated waveform feature detection ... many electrophysiology specific functions including ...
A431 cells Source: Cell Lysate Form: Ready to Use Application: Western Blotting Control...
A431 cells stimulated with EGF Source: Cell Lysate Form: Ready to Use Application: Western Blotting Control...
Biology Products: