Navigation Links
Researchers Able to Identify that Benign Tumors from Use of Oral Contraceptive Have a Greater Chance of Becoming Malignant
Date:11/3/2013

WASHINGTON, Nov. 3, 2013 /PRNewswire/ -- Although very rare, the use of oral contraceptive can lead to benign tumors in the liver. The tumors, known as hepatocellular adenomas, can become malignant. It is, however, difficult for physicians to assess the risk of these tumors becoming malignant.

The study's researchers examined and classified data from 250 patients with hepatocellular adenomas. They examined classical adenomas (223), borderline lesions between adenomas and carcinomas (18), and carcinomas (9). The data was examined using whole exome sequencing, CGH-SNP analyses, and methylome analyses.

Researchers were able to identify the genetic determinants of malignant transformation as well as the key factors at stages of the transformation. "Our work reported for the first time a molecular mechanism of malignant transformation of hepatocellular adenomas to carcinomas," lead researcher, Camilla Pilati, PhD, said, "Surprisingly, we were able to identify the chronology of the genetic defects that accumulate in hepatocytes to promote their malignant transformation. In this line, we identified genetic alteration that acts at early and late steps of the malignant transformation process, in the accumulation of early genetic alteration at the origin of the malignant transformation of the hepatocytes."

Two genes with somatic mutations -- one in the early stages and one in the later stages -- were identified in the malignant transformation. Mutations of beta-catenin are associated with many forms of cancer, and beta-catenin activation and TERT promoter mutations in the early and later stages, respectively, were identified in the malignancy process. In addition, the researchers were able to identify factors that determined adenomas that were not at a high risk of becoming carcinoma.

"This work provided new insights about the major genetic determinants of malignant transformation and thei
'/>"/>

SOURCE American Association for the Study of Liver Diseases (AASLD)
Copyright©2012 PR Newswire.
All rights reserved

Page: 1 2 3

Related biology news :

1. Children of lower socioeconomic status grow up more susceptible to catching colds, Carnegie Mellon researchers find
2. University of Louisville researchers sign global licensing agreement
3. BUSM researchers study epigenetic mechanisms of tumor metastasis for improved cancer therapy
4. Researchers quantify toxic ocean conditions during major extinction 93.9 million years ago
5. Researchers discover how cancer invisibility cloak works
6. Oregon researchers say supplement cuts muscle loss in knee replacements
7. BUSM researchers identify molecule that could aid lung cancer detection, treatment
8. Researchers identify gene variant that raises risk for colorectal cancer from eating processed meat
9. Researchers show how plants tell the time
10. Berkeley Lab researchers get a detailed look at a DNA repair protein in action
11. Researchers capture images of open channel that moves proteins across cell membranes
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/9/2014)... which animals can be found, concern mounts over the ... range for a host mean new territory for its ... of UC Santa Barbara scientists, including parasitologists Ryan Hechinger ... Journal of Biogeography , Hechinger, Kuris and colleagues ... Hosts may actually lose their parasites when the hosts ...
(Date:7/9/2014)... derived from the oils produced by algae may offer ... this goal, optimization of cost effective strategies for large-scale ... needed. Sapphire Energy has developed an innovative solution to ... systems, described in Industrial Biotechnology , a peer-reviewed ... is available on the Industrial Biotechnology ...
(Date:7/9/2014)... Ill. With over 100 diseases that can attack ... top of the most wanted list? University of Illinois ... that more research is needed on the fungus that ... with cool, damp growing conditions but Macrophomina phaseolina ... and dry drought conditions. , "As the climate continues ...
Breaking Biology News(10 mins):Not at home on the range 2Not at home on the range 3Not at home on the range 4Controlling contamination in open algae ponds for biofuels 2Climate change provides good growing conditions for charcoal rot in soybeans 2Climate change provides good growing conditions for charcoal rot in soybeans 3
... The University of Nottingham are to receive more than 5 ... make rural living in both the UK and India more ... opportunities for small scale energy generation through renewable sources, developing ... of mobile technologies to grow wealth in rural communities. , ...
... landscapes have undergone great change in recent decades, but species ... roe deer, Spanish ibex, red deer and wild boar. ... the effects of changes in land use on the past, ... last few decades there has been an increase in the ...
... serious gastric disorders including stomach cancer may be a step ... chemist. In the first published study of its kind, ... found a carbohydrate-based antigen caused mice to develop antibodies against ... the first jab at a sugar-based vaccine against Helicobacter ...
Cached Biology News:Nottingham researchers help bridge the urban and rural divide in the UK and India 2Nottingham researchers help bridge the urban and rural divide in the UK and India 3Nottingham researchers help bridge the urban and rural divide in the UK and India 4Changes in land use favor the expansion of wild ungulates 2
(Date:1/14/2014)... EquitiesIQ, a leading informational research provider, has ... an emerging biomedical company acquiring, developing, manufacturing, and marketing ... Free report download: http://equitiesiq.com/reports/alliqua/ , In late ... and Board, which launched the company’s new strategy to ...
(Date:1/14/2014)... January 14, 2014 In recent years, ... and methods in product development and promotion has led ... This mistrust, fueled by concerns about the insidious impact ... reports of spectacular fines to the world’s biggest pharmas ...
(Date:1/14/2014)... Cardiff, UK (PRWEB) January 13, 2014 ... leader with more than 20 years in the industry, ... and photonics . Hainsey will serve as the society’s ... have Dr. Hainsey join SPIE as our Technology Strategist, ...
(Date:1/14/2014)... (PRWEB) January 14, 2014 BioMedomics, Inc. ... ultra-sensitive POC diagnostic platforms and novel disease specific POC tests, ... of financing netting a total of $690,000. The investment is ... in the company. This group of private investors has significant ...
Breaking Biology Technology:EquitiesIQ Initiates Coverage of Alliqua, Inc. 2EquitiesIQ Initiates Coverage of Alliqua, Inc. 3The Sunshine Act: Necessary Regulation or Unnecessary Dysregulation? New Life Science Webinar Hosted by Xtalks and IRB Services 2The Sunshine Act: Necessary Regulation or Unnecessary Dysregulation? New Life Science Webinar Hosted by Xtalks and IRB Services 3Photonics R&D Leader Bob Hainsey Joins SPIE Technical Staff 2BioMedomics, Inc. Closes $690K Round of Financing 2
... naturally occurring antibodies contained in, GAMMAGARD LIQUID ... disease, CHICAGO, April 15 The University ... (NYSE: BAX ) today,announced data from a ... [Immune Globulin Intravenous (Human)] (IGIV),marketed as KIOVIG in ...
... BIRMINGHAM, Ala., and CEDARHURST, N.Y., April 15 ,BioHorizons, ... of Implant Logic Systems, Ltd. ("ILS"), first announced ... as a subsidiary of,BioHorizons. Steve Boggan, CEO of ... offering to include VIP Virtual Implant Placement,planning software ...
... PALO ALTO, Calif., April 15 CV Therapeutics,Inc. ... Capital has agreed to pay,CV Therapeutics up to ... percent of,CV Therapeutics, royalty on North American sales ... on closing,of the transaction and could receive a ...
Cached Biology Technology:Study Suggests GAMMAGARD LIQUID May Target the Primary Pathway Involved in Alzheimer's Disease 2Study Suggests GAMMAGARD LIQUID May Target the Primary Pathway Involved in Alzheimer's Disease 3Study Suggests GAMMAGARD LIQUID May Target the Primary Pathway Involved in Alzheimer's Disease 4Study Suggests GAMMAGARD LIQUID May Target the Primary Pathway Involved in Alzheimer's Disease 5BioHorizons Announces the Purchase of Implant Logic Systems 2CV Therapeutics Announces $185 Million Transaction with TPG-Axon Capital for Half of Royalty for Lexiscan(TM) (regadenoson) Injection 2CV Therapeutics Announces $185 Million Transaction with TPG-Axon Capital for Half of Royalty for Lexiscan(TM) (regadenoson) Injection 3
... Channel Cell Lines ,High Quality, Functionally-Validated, Ion ... well known for having a critical role ... have a key function in pain, CNS ... channels have been investigated in therapeutic areas, ...
Mouse monoclonal antibody raised against a full length recombinant SLC25A11. NCBI Entrez Gene ID = SLC25A11...
... antibody raised against a partial ... Immunogen: TOPORS (NP_005793, 98 ... recombinant protein with GST tag. ... NM_005802 ...
Mouse monoclonal antibody raised against a full length recombinant SNAPC5. NCBI Entrez Gene ID = SNAPC5...
Biology Products: