Navigation Links
Researcher finds potential new use for old drugs
Date:11/12/2013

PULLMAN, Wash. A class of drugs used to treat parasitic infections such as malaria may also be useful in treating cancers and immune-related diseases, a new WSU-led study has found.

Researchers discovered that simple modifications to the drug furamidine have a major impact on its ability to affect specific human proteins involved in the on-off switches of certain genes.

"This was rather unexpected, given how relatively simple the molecules are that we modified and how difficult it has been to affect these proteins," said Gregory Poon, pharmaceutical scientist at Washington State University.

The proteins known as transcription factors regulate the expression of genes in a highly coordinated and intricate manner, making them attractive targets for therapeutic drugs. But it has proven difficult to design drugs to affect them, Poon said.

"For this reason, they have been called undruggable," he said. "Recently, however, scientists have been making headway in targeting these transcription factors with drugs, and now our results suggest this class of drugs can be a useful addition to the arsenal."

Furamidine belongs to a family of drugs known as heterocyclic dications. The drug has a long history of use in serious parasitic diseases such as malaria, African sleeping sickness and PCP, a common infection in HIV/AIDS.

"There is tremendous knowledge and experience with using furamidine and related drugs in humans, so these drugs have an important advantage over other classes of drugs that are relatively behind in clinical experience," Poon said.

Poon collaborated with researchers at Georgia State University. The team found that derivatives of furamidine can target a specific transcription factor known as PU.1.

PU.1 is a major factor in development and function of the human immune system, and it plays important roles in diseases such as some leukemias, multiple sclerosis and diabetes. PU.1 is also a member of a large family of related transcription factors, known as ETS, that is involved in a broader range of cancers and other diseases.

"I am fortunate to be working with some of the best people in this area," Poon said, referring to his collaborators, Dave Boykin and David Wilson of Georgia State University. "The challenge now is to fine-tune this class of drugs to make them as specific as possible to other ETS-family transcription factors as well."


'/>"/>

Contact: Gregory Poon
gpoon@wsu.edu
509-335-8341
Washington State University
Source:Eurekalert

Related biology news :

1. Using morphine after abdominal surgery may prolong pain, CU-Boulder researchers find
2. Wayne State researchers discover specific inhibitor for rheumatoid arthritis treatment
3. Protein illustrates muscle damage: McMaster researchers
4. NSF awards to UT Arlington researchers will fuel sustainable solutions
5. Researchers uncover origins of cattle farming in China
6. UT Southwestern researchers identify how body clock affects inflammation
7. Researchers suggest plan to address hypoxia in Gulf of Mexico
8. Researchers advocate for climate adaptation science
9. UMMS researchers answer century old question about 3D structure of mitotic chromosomes
10. NIH funds researchers using light to control and monitor neural activity
11. Researchers regrow hair, cartilage, bone, soft tissues
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:11/24/2016)... 2016 Cercacor today introduced Ember TM ... non-invasively measure hemoglobin, Oxygen Content, Oxygen Saturation, ... Rate in approximately 30 seconds. Smaller than a smartphone, ... access to key data about their bodies to help ... Hemoglobin carries oxygen to muscles. When ...
(Date:11/17/2016)... 2016 Global Market Watch: Primarily supported ... Population-Based Banks and Academics) market is to witness a value ... shows the highest Compounded Annual Growth Rate (CAGR) of 10.75% ... the analysis period 2014-2020. North America ... by Europe at 9.56% respectively. ...
(Date:11/14/2016)... SARASOTA, Fla., Nov. 14, 2016  xG Technology, Inc. ... in providing critical wireless communications for use in challenging ... ended September 30, 2016. Management will hold a conference ... at 5:00 p.m. Eastern Time (details below). ... announced a $16 million binding agreement to acquire Vislink ...
Breaking Biology News(10 mins):
(Date:12/8/2016)... San Francisco, CA (PRWEB) , ... December 08, ... ... and Oculus as finalists in the World Technology Awards. uBiome is one of ... were received across all categories. , In addition to uBiome, companies nominated as ...
(Date:12/8/2016)... , Dec. 8, 2016 Savannah ... remediation technologies and selected NewTechBio,s NT-MAX Lake ... microbial based beneficial bacteria, in conjunction with Hexa ... correct deficiencies with National Pollutant Discharge Elimination System ... has experienced a steady history of elevated pH ...
(Date:12/7/2016)... (PRWEB) , ... December 07, 2016 , ... ... journal has concluded that “in the setting of previously treated, advanced pancreatic cancer, ... in defining the optimal patient population and timing of blood sampling may improve ...
(Date:12/7/2016)... Ontario , Dec. 7, 2016  Nordion, ... with General Atomics (GA), welcome today,s award by ... Nuclear Security Administration (NNSA) of the Phase II ... project with Nordion and the University of Missouri ... II funding will support the establishment of a ...
Breaking Biology Technology: