Navigation Links
Researcher finds potential new use for old drugs
Date:11/12/2013

PULLMAN, Wash. A class of drugs used to treat parasitic infections such as malaria may also be useful in treating cancers and immune-related diseases, a new WSU-led study has found.

Researchers discovered that simple modifications to the drug furamidine have a major impact on its ability to affect specific human proteins involved in the on-off switches of certain genes.

"This was rather unexpected, given how relatively simple the molecules are that we modified and how difficult it has been to affect these proteins," said Gregory Poon, pharmaceutical scientist at Washington State University.

The proteins known as transcription factors regulate the expression of genes in a highly coordinated and intricate manner, making them attractive targets for therapeutic drugs. But it has proven difficult to design drugs to affect them, Poon said.

"For this reason, they have been called undruggable," he said. "Recently, however, scientists have been making headway in targeting these transcription factors with drugs, and now our results suggest this class of drugs can be a useful addition to the arsenal."

Furamidine belongs to a family of drugs known as heterocyclic dications. The drug has a long history of use in serious parasitic diseases such as malaria, African sleeping sickness and PCP, a common infection in HIV/AIDS.

"There is tremendous knowledge and experience with using furamidine and related drugs in humans, so these drugs have an important advantage over other classes of drugs that are relatively behind in clinical experience," Poon said.

Poon collaborated with researchers at Georgia State University. The team found that derivatives of furamidine can target a specific transcription factor known as PU.1.

PU.1 is a major factor in development and function of the human immune system, and it plays important roles in diseases such as some leukemias, multiple sclerosis and diabetes. PU.1 is also a member of a large family of related tra
'/>"/>

Contact: Gregory Poon
gpoon@wsu.edu
509-335-8341
Washington State University
Source:Eurekalert

Page: 1 2

Related biology news :

1. Using morphine after abdominal surgery may prolong pain, CU-Boulder researchers find
2. Wayne State researchers discover specific inhibitor for rheumatoid arthritis treatment
3. Protein illustrates muscle damage: McMaster researchers
4. NSF awards to UT Arlington researchers will fuel sustainable solutions
5. Researchers uncover origins of cattle farming in China
6. UT Southwestern researchers identify how body clock affects inflammation
7. Researchers suggest plan to address hypoxia in Gulf of Mexico
8. Researchers advocate for climate adaptation science
9. UMMS researchers answer century old question about 3D structure of mitotic chromosomes
10. NIH funds researchers using light to control and monitor neural activity
11. Researchers regrow hair, cartilage, bone, soft tissues
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:11/6/2014)... paper from a team of Florida State University biologists ... could adapt to and survive environmental swings such as ... latest issue of the journal The Plant Cell ... DNA and proteins) is organized in a cell and ... are turned on and others are turned off. , ...
(Date:11/6/2014)... - Insilico Medicine, Inc, a Baltimore-based bioinformatics company ... diseases announced a research collaboration with the international ... Inc (OTC: CSBR). , "There are many companies ... Champions Oncology,s TumorGraft technology is unique in a ... experimentally generating vast amounts of valuable data. Our ...
(Date:11/5/2014)... great diversity in their ability to identify scents and ... in their perceptual evaluation of odors, with women outperforming ... , Sex differences in olfactory detection may play a ... to one,s perception of smell, which is naturally linked ... has been suggested to be cognitive or emotional, rather ...
Breaking Biology News(10 mins):Maize analysis yields whole new world of genetic science 2Insilico Medicine, Inc announces research collaboration with Champions Oncology, Inc 2The female nose always knows: Do women have more olfactory neurons? 2
... University of Copenhagen lead the way for future monitoring of ... samples to keep track of fish and whales in the ... local fish and whale faunas and combat traditional fishing methods. ... PLOS ONE . "The new DNA-method means that ...
... political targets to significantly reduce and halt biodiversity loss. ... setting up of new targets for 2020. In addition, ... been incorporated in several global and the EU agendas ... a critical review of the existing and emerging biodiversity ...
... the political targets to significantly reduce and halt biodiversity ... the setting up of new targets for 2020. In ... has been incorporated in several global and the EU ... requires a critical review of the existing and emerging ...
Cached Biology News:New DNA-method tracks fish and whales in seawater 2Biodiversity conservation depends on scale: Lessons from the science-policy dialogue 2Biodiversity conservation depends on scale: Lessons from the sience-policy dialogue 2
(Date:11/21/2014)... 20, 2014 Offering a complete line ... Entris Balance promotion . The Sartorius Entris Balance is ... high accuracy, and easy-to-maintain balance entry level balance. , ... was designed to help customer’s bridge the gap between ... that is very durable. Sartorius is the second biggest ...
(Date:11/21/2014)... (PRWEB) November 20, 2014 The ... public policy research organization representing leading California academic ... and PwC US today released a ... life sciences industry growth. The trend shows a ... 2015 California Biomedical Industry Report indicates ...
(Date:11/21/2014)... 2014 The November 2014 issue of ... open access journal featuring the following articles:, ... preserve photoresponsiveness in the retina , DNA ... hybridization using chromogenic substrates in zebrafish , ... protein electrophoresis , Nuclear LC3-positive puncta in ...
(Date:11/21/2014)... November 21, 2014 Why did Stephen ... Albert Einstein so instantly recognizable? Why have they become ... astronomer and author Hilton Ratcliffe seeks out the answers ... at all to do with science. In " Stephen ... , November 21, 2014), Ratcliffe puts it plainly: ...
Breaking Biology Technology:Pipette.com Announces an Extension on the Sartorius Entris Balance Promotion to the End of 2014 2California Healthcare Institute and PwC Report Boom in California’s Biomedical Industry 2California Healthcare Institute and PwC Report Boom in California’s Biomedical Industry 3California Healthcare Institute and PwC Report Boom in California’s Biomedical Industry 4BioTechniques: The International Journal of Life Science Methods Announces the Publication of the November 2014 Issue—Available in Print and Online 2BioTechniques: The International Journal of Life Science Methods Announces the Publication of the November 2014 Issue—Available in Print and Online 3“Stephen Hawking Smoked My Socks” Sparks Controversy in Science World 2“Stephen Hawking Smoked My Socks” Sparks Controversy in Science World 3“Stephen Hawking Smoked My Socks” Sparks Controversy in Science World 4
... VEENENDAAL, The Netherlands, June 2 ... today announced the creation,of an exclusive partnership and ... for an undisclosed sum. The two companies, headquartered ... the combination,will strengthen Nucletron,s position as global leader ...
... The American Institute of Aeronautics and Astronautics ... top emerging aerospace technologies. Developed by AIAA,s ... following: 1. "Greener Aviation" Technologies including emission ... the Federal Aviation Administration,s Continuous Low Emissions, Energy ...
... First Randomized Trial to Demonstrate Superior Clinical Benefit in Relapsed/Refractory Aggressive NHL , ... to treat Analysis results per FDA agreed upon Statistical Analysis Plan , ... Significant Increase in Complete Remission Rates 20% vs. 5.7%; p=0.021 ... Rate 37.1% vs. 14.3%; p=0.003 , ...
Cached Biology Technology:Dutch Medical Equipment Producer Nucletron Strengthens Leading Position in Cancer Radiation Therapy Market 2Dutch Medical Equipment Producer Nucletron Strengthens Leading Position in Cancer Radiation Therapy Market 3AIAA names top ten emerging aerospace technologies of 2009 2Pixantrone Significantly Increases Complete Remissions, Overall Response Rates, Frequency of Durable Remissions and Progression Free Survival in Patients with Relapsed and Refractory Aggressive Non-Hodgkin's Lymphoma 2Pixantrone Significantly Increases Complete Remissions, Overall Response Rates, Frequency of Durable Remissions and Progression Free Survival in Patients with Relapsed and Refractory Aggressive Non-Hodgkin's Lymphoma 3Pixantrone Significantly Increases Complete Remissions, Overall Response Rates, Frequency of Durable Remissions and Progression Free Survival in Patients with Relapsed and Refractory Aggressive Non-Hodgkin's Lymphoma 4Pixantrone Significantly Increases Complete Remissions, Overall Response Rates, Frequency of Durable Remissions and Progression Free Survival in Patients with Relapsed and Refractory Aggressive Non-Hodgkin's Lymphoma 5
SlowFade Antifade Kit with DAPI...
...
... SAGE (serial analysis of ... genome-wide expression analysis. Expression profiles ... enough to detect low-abundance transcripts ... novel genes. The I-SAGE Kit ...
Mycoplasma tested...
Biology Products: