Navigation Links
Researcher finds altered cerebella in those with Down syndrome
Date:8/24/2011

AURORA, Colo. (Aug. 24, 2011) A scientist investigating why those with Down syndrome often have poor balance and motor coordination has found that key eye reflexes are substantially altered.

The findings by University of Colorado School of Medicine researcher Alberto Costa, MD, Ph.D., could lead to new tools to assess the effectiveness of new drugs and therapies aimed at improving quality of life for those with this genetic disorder.

"People with Down syndrome suffer various degrees of motor difficulty," said Costa, whose study was published last week in the journal, Experimental Brain Research. "They tend to walk later than their typical peers; they often lack balance and have low muscle tone and poor postural control."

That's likely because Down syndrome affects the optokinetic and vestibular systems of the brain. In a healthy brain, the vestibular system reacts to signals from neuroreceptors in the inner ear to produce responses to head movements. The optokinetic system uses visual information to produce eye movement. These reactions are often slow or decreased in those with Down syndrome.

Costa studied 32 participants between the ages of 14 and 36. He used special binocular goggles to measure eye movements in response to visual and vestibular stimuli. His focus was the cerebellum which is responsible for balance, posture and movement control.

"Although we have known for many years that the cerebellum is disproportionally shrunk in persons with Down syndrome, we wanted to find out how their cerebella operated on a functional level," Costa said. "We found that people with Down had much diminished optokinetic and vestibular reflexes compared to typically developing individuals. As a consequence, it is likely that things may appear blurry when they ride a bike or play sports."

Because those with Alzheimer's disease also show a similar reduction in the optokinetic reflex, these new findings further support Costa's ongoing exploration of the links between Down and Alzheimer's disease.

"All individuals with Down syndrome develop a neuropathology indistinguishable from Alzheimer's disease after the third decade of life," he said.

Babies born with Down often carry the biological markers for Alzheimer's. At the same time, 20-30 percent of those with Down syndrome develop full-blown Alzheimer's dementia by the time they reach their 50s, he said.

Costa recently completed a clinical trial with the drug Memantine used to treat Alzheimer's patients - to determine if it could boost memory and learning in those with Down syndrome. His work was chronicled in a lengthy New York Times Magazine profile earlier this month.

"Alzheimer's patients suffer similar declines to those with Down syndrome and we might be able to use the same drugs to treat both," he said. "As we continue to explore how these two conditions are linked, new avenues of treatment could arise that would not only alleviate symptoms but perhaps delay or stop the progression of these degenerative disorders."


'/>"/>

Contact: David Kelly
david.kelly@ucdenver.edu
303-315-6374
University of Colorado Denver
Source:Eurekalert

Related biology news :

1. UC Davis researchers find disease-causing fat cells in those with metabolic syndrome
2. Researchers uncover source of Haitian cholera outbreak
3. VBI, Convey Computer partner to deliver technology to biomedical, life sciences researchers
4. Cleveland researchers collaborate to launch Phase 1 clinical trial for new MS treatment
5. UT researchers develop algorithm to improve remote electrocardiography
6. TGen and DTU researchers track source of Haitian cholera outbreak
7. UH researchers explore treatments for breast and colon cancers
8. Not so fast -- researchers find that lasting evolutionary change takes about 1 million years
9. Joslin researchers identify new target for treatment of type 2 diabetes and prediabetes
10. Southampton researchers awarded $28 million to progress pioneering nutrition and respiratory research
11. Researchers on the trail of a treatment for cancer of the immune system
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/18/2016)... March 18, 2016 --> ... Biometrics, ICT, Manned & Unmanned Vehicles, Physical infrastructure and Perimeter ... companies in the border security market and the continuing migration ... Europe has led visiongain to publish ... success. --> defence & security companies in ...
(Date:3/14/2016)... March 14, 2016 http://www.apimages.com ... --> - Renvoi : image disponible via ... --> --> DERMALOG, le ... de nouveaux lecteurs d,empreintes digitales pour l,enregistrement des ... sera utilisé pour produire des cartes d,identité aux ...
(Date:3/9/2016)... 2016 This BCC Research report provides an ... RNA Sequencing (RNA Seq) market for the years 2015, ... and reagents, data analysis, and services. Use ... RNA-Sequencing market such as RNA-Sequencing tools and reagents, RNA-Sequencing ... affecting each segment and forecast their market growth, future ...
Breaking Biology News(10 mins):
(Date:4/29/2016)... CA (PRWEB) , ... April 29, 2016 , ... Summit ... (NSCF) to support the development of a patient-specific stem cell therapy for the treatment ... the lab of Dr. Jeanne Loring at The Scripps Research Institute in San Diego, ...
(Date:4/28/2016)... , April 28, 2016 The ... and Brayton Cryocoolers), Service (Technical Support, Product Repairs & ... - Global Forecast to 2022", published by MarketsandMarkets, the ... Billion by 2022, at a CAGR of 7.29% between ... data Tables and 94 Figures spread through 159 Pages ...
(Date:4/28/2016)... , ... April 28, 2016 , ... ... will deliver a talk on its first-in-class technologies for tissue stem cell ... Meeting on RNAiMicroRNA Biology to Reprogramming & CRISPR-based Genome Engineering in Burlington, ...
(Date:4/27/2016)... ... ... Cambridge Semantics, the leading provider of Smart Data analytic and data management ... The Silicon Review’s “20 Fastest Growing Big Data Companies of 2016.” , “From ... end users facing some of the most complex data challenges in the industry,” said ...
Breaking Biology Technology: