Navigation Links
Researcher awarded $1.2 million grant to study centrosomes and cilia
Date:9/22/2009

TALLAHASSEE, Fla. -- If you don't know how a human cell is supposed to work, it's hard to offer a good explanation when the cell goes haywire -- as it does in cancer. That's why a Florida State University College of Medicine researcher has been awarded a $1.2 million grant to explore the role of centrosomes and cilia in cell division and development and their connections to human disease.

Tim Megraw, a veteran researcher who joined the College of Medicine as an associate professor in August, received the four-year grant from the National Institutes of Health this month. The grant continues through August 2013.

The focus of Megraw's work is cell division. Cancer occurs when renegade cells start dividing uncontrollably. Anti-cancer drugs such as Taxol, Megraw noted, target the microtubule, a key molecule that regulates cell division. Along with other areas of focus, he's looking into microtubule regulation and its relationship to another component of the cell called the centrosome.

"We're studying how microtubules are regulated in cells normally," Megraw said, "and the key roles that the centrosomin family of proteins play in this process. Centrosomes are the main centers for organizing microtubules. So we're interested in how centrosomes are assembled and regulated. Both of those goals are outlined in this new grant."

Remarkably, centrosomins regulate not only centrosome assembly and their functions in cytoskeleton assembly, but also the replication of centrosomes in the cell cycle.

This is a continuation of work Megraw and his wife, Ling-Rong Kao, now an assistant in research at the medical school, began in 2003 at the University of Texas Southwestern Medical Center in Dallas. They have explored cells in the brain of the fruit fly and, more recently, the mouse.

Based on their work, researchers better understand the nature of centrosome-based diseases.

"Most of the diseases affect these little hair-like structures that stick out of our cells -- cilia," said Megraw, noting that interest in cilia has experienced a renaissance in recent years. "It's funny because, if you read a review article from 15 or 20 years ago, people wrote statements like 'These appear to be useless vestiges.' And now they appear to be key signaling centers. I have trouble keeping up with the list of diseases that are now associated with defective cilia."

Among those diseases are polycystic kidney disease, as well as other syndromes that lead to deafness, visual degeneration, obesity and primary microcephaly, a condition in which brain development is impaired.


'/>"/>

Contact: Ron Hartung
ronald.hartung@med.fsu.edu
850-645-9205
Florida State University
Source:Eurekalert

Related biology news :

1. Nanoresearchers challenge dogma in protein transportation in cells
2. Ben-Gurion University Alzheimers researcher demonstrates specific immune response to vaccine
3. 1 million euro EU grant for MDC diabetes researcher Dr. Francesca M. Spagnoli
4. MDC researchers discover molecule responsible for axonal branching
5. Cybernetwork to help K-State researchers study tallgrass prairie, respond to global warming
6. UH Manoa researcher examines possible implications of daily commute and mosquito-borne diseases
7. Researchers prolong the half-life of biopharmaceutical proteins
8. Barrow researcher finds natural hydrogel helps heal spinal cord
9. WCMC-Q researchers unlock genetic secrets of date palm
10. Weeding out marijuana: Researchers close in on engineering recognizable, drug-free Cannabis plant
11. Dartmouth researchers get personal with genetics
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/30/2017)... ANGELES , March 30, 2017  On April ... Hack the Genome hackathon at Microsoft,s ... exciting two-day competition will focus on developing health and ... Hack the Genome is the ... been tremendous. The world,s largest companies in the genomics, ...
(Date:3/28/2017)... 2017 The report "Video Surveillance ... Servers, Storage Devices), Software (Video Analytics, VMS), and Service ... Forecast to 2022", published by MarketsandMarkets, the market was ... projected to reach USD 75.64 Billion by 2022, at ... base year considered for the study is 2016 and ...
(Date:3/23/2017)... , March 23, 2017 The report "Gesture Recognition ... Biometric), Industry, and Geography - Global Forecast to 2022", published by MarketsandMarkets, the ... a CAGR of 29.63% between 2017 and 2022. ... ... ...
Breaking Biology News(10 mins):
(Date:5/23/2017)... (PRWEB) , ... May 23, 2017 , ... ... celebrates this month its 20th anniversary, marking the occasion with a strong presence ... the meeting’s Welcome Reception and further extends an invitation to all attendees to ...
(Date:5/23/2017)... ... ... Vortex Biosciences , provider of circulating tumor cell (CTC) capture systems, ... Vortex microfluidic technology ” in Nature Precision Oncology on May 8th. The peer ... Dr. Matthew Rettig at the University of California, Los Angeles. The publication describes the ...
(Date:5/23/2017)... ... 23, 2017 , ... Bacterial biofilms, surface adherent communities of bacteria that are ... from food poisoning and catheter infections to gum disease and the rejection of medical ... of dollars per year, there is currently a paucity of means for preventing their ...
(Date:5/22/2017)... Boston, MA (PRWEB) , ... May 22, 2017 , ... ... evidence, has expanded to the East Coast. It has opened an office in downtown ... innovative therapies are finding it increasingly more important to generate evidence on the value ...
Breaking Biology Technology: