Navigation Links
Researcher awarded $1.2 million grant to study centrosomes and cilia
Date:9/22/2009

TALLAHASSEE, Fla. -- If you don't know how a human cell is supposed to work, it's hard to offer a good explanation when the cell goes haywire -- as it does in cancer. That's why a Florida State University College of Medicine researcher has been awarded a $1.2 million grant to explore the role of centrosomes and cilia in cell division and development and their connections to human disease.

Tim Megraw, a veteran researcher who joined the College of Medicine as an associate professor in August, received the four-year grant from the National Institutes of Health this month. The grant continues through August 2013.

The focus of Megraw's work is cell division. Cancer occurs when renegade cells start dividing uncontrollably. Anti-cancer drugs such as Taxol, Megraw noted, target the microtubule, a key molecule that regulates cell division. Along with other areas of focus, he's looking into microtubule regulation and its relationship to another component of the cell called the centrosome.

"We're studying how microtubules are regulated in cells normally," Megraw said, "and the key roles that the centrosomin family of proteins play in this process. Centrosomes are the main centers for organizing microtubules. So we're interested in how centrosomes are assembled and regulated. Both of those goals are outlined in this new grant."

Remarkably, centrosomins regulate not only centrosome assembly and their functions in cytoskeleton assembly, but also the replication of centrosomes in the cell cycle.

This is a continuation of work Megraw and his wife, Ling-Rong Kao, now an assistant in research at the medical school, began in 2003 at the University of Texas Southwestern Medical Center in Dallas. They have explored cells in the brain of the fruit fly and, more recently, the mouse.

Based on their work, researchers better understand the nature of centrosome-based diseases.

"Most of the diseases affect these little hai
'/>"/>

Contact: Ron Hartung
ronald.hartung@med.fsu.edu
850-645-9205
Florida State University
Source:Eurekalert

Page: 1 2

Related biology news :

1. Nanoresearchers challenge dogma in protein transportation in cells
2. Ben-Gurion University Alzheimers researcher demonstrates specific immune response to vaccine
3. 1 million euro EU grant for MDC diabetes researcher Dr. Francesca M. Spagnoli
4. MDC researchers discover molecule responsible for axonal branching
5. Cybernetwork to help K-State researchers study tallgrass prairie, respond to global warming
6. UH Manoa researcher examines possible implications of daily commute and mosquito-borne diseases
7. Researchers prolong the half-life of biopharmaceutical proteins
8. Barrow researcher finds natural hydrogel helps heal spinal cord
9. WCMC-Q researchers unlock genetic secrets of date palm
10. Weeding out marijuana: Researchers close in on engineering recognizable, drug-free Cannabis plant
11. Dartmouth researchers get personal with genetics
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/19/2014)... LaunchKey , the first decentralized mobile authentication and authorization ... era, today announced the close of $3 million in ... Metamorphic Ventures with participation from ENIAC Ventures, Crosslink Capital, ... has raised $4 million to date, and will use ...
(Date:12/17/2014)... , Dec. 16, 2014 Research and Markets ... the "Global Chemical Sensor Market 2015-2019" report ... One major trend upcoming in this ... biomedical applications. Chemical sensors help in recording of patient ...
(Date:12/11/2014)... blood pressure plays a role in human health has been ... for high blood pressure – was first described as a ... used in measuring blood pressure was invented in 1896. ... its triggers and its effects. In fact, recent findings have ...
Breaking Biology News(10 mins):LaunchKey Raises $3 Million in Additional Funding Led by Metamorphic Ventures 2LaunchKey Raises $3 Million in Additional Funding Led by Metamorphic Ventures 3Global Chemical Sensor Market 2015-2019: Key Vendors are Abbott Laboratories, Bayer, Hoffmann La-Roche, Johnson & Johnson, NGK Spark Plugs and Robert Bosch 2Research points to need for new approaches to treatment of high blood pressure 2Research points to need for new approaches to treatment of high blood pressure 3Research points to need for new approaches to treatment of high blood pressure 4
... in German . , X-ray microscopy ... obtain sharp images instrument and sample must stay absolutely ... Researchers at the Technische Universitaet Muenchen and the Paul ... method that relaxes these hard restrictions. Even fluctuations in ...
... But it,s a dog-eat-dog world, and with the exception of ... this vicious reality, a tiny insect that eats plants has ... its beetle predator. The pest is called the ... recent years has caused immeasurable loss of biodiversity. Cycads belong ...
... closer look at personalized or point-of-care healthcare was ... India organized and chaired by NJIT Distinguished Professor ... and Biology Society (EMBS) International Special Topic Conference ... world, focused on topics ranging from 21st century ...
Cached Biology News:Improved X-ray microscopic imaging 2Pest uses plant hairs for protection 2Personalized health care will revolutionize 21st century medicine, says NJIT professor 2Personalized health care will revolutionize 21st century medicine, says NJIT professor 3
(Date:12/24/2014)... 2014  United Therapeutics Corporation (NASDAQ: UTHR ) ... ) has submitted a pre-market approval application to the ... of Medtronic,s SynchroMed ® II implantable drug infusion ... United Therapeutics, Remodulin ® (treprostinil) Injection delivered intravenously ...
(Date:12/24/2014)...  Vermillion, Inc. (Nasdaq:   VRML), a bio-analytical solutions ... the Company closed its previously announced private placement ... W. Schuler , Birchview Fund LLC and several ... offering expenses.  The proceeds will be used for ...
(Date:12/24/2014)... December 23, 2014 “Preparative & ... HPLC, Flash), Consumables (Columns, Solvents, Buffers, Valves, Guages, ... & Agriculture) - Forecasts to 2019” provides a ... opportunities, current market trends, and strategies impacting the ...
(Date:12/24/2014)... (PRWEB) December 23, 2014 Earlier this year ... Sherley, director of the Adult Stem Cell Technology Center, LLC ... under appreciated unique property of adult tissue stem cells. ... the Past, Important for the Future,” embodied the essence of ...
Breaking Biology Technology:United Therapeutics Announces Submission Of Pre-Market Approval Application For Implantable Drug Infusion System To Deliver Remodulin 2United Therapeutics Announces Submission Of Pre-Market Approval Application For Implantable Drug Infusion System To Deliver Remodulin 3United Therapeutics Announces Submission Of Pre-Market Approval Application For Implantable Drug Infusion System To Deliver Remodulin 4Vermillion Announces Closing of Equity Financing 2Vermillion Announces Closing of Equity Financing 3Preparative and Process Chromatography Market is expected to reach $9 billion by 2019 - New Report by Marketsandmarkets 2Preparative and Process Chromatography Market is expected to reach $9 billion by 2019 - New Report by Marketsandmarkets 3Preparative and Process Chromatography Market is expected to reach $9 billion by 2019 - New Report by Marketsandmarkets 4Adult Stem Cell Technology Center, LLC’s Director Sherley's Address on What’s Holding Back Regenerative Medicine Featured on Omics Group Website 2Adult Stem Cell Technology Center, LLC’s Director Sherley's Address on What’s Holding Back Regenerative Medicine Featured on Omics Group Website 3Adult Stem Cell Technology Center, LLC’s Director Sherley's Address on What’s Holding Back Regenerative Medicine Featured on Omics Group Website 4
... Abbott (NYSE: ABT ),will present at the 26th ... Thomas C. Freyman, executive vice president, finance and,chief financial ... at,11:00 a.m. Central time., A live audio webcast ... Web site at http://www.abbottinvestor.com . An,archived edition of ...
... Solstice Neurosciences, Inc.,("Solstice") announced the appointment of Dennis ... will also continue to serve as Chairman to ... specialty pharmaceutical industry experience,and expertise to Solstice that ... for growth as the company continues to broaden,its ...
... & Forbes Holdings Inc.,announced today that Dr. Eric ... also serves as Chief Executive Officer of SIGA ... Science Board (NBSB). The,NBSB will provide expert advice ... technical and other matters of special interest to ...
Cached Biology Technology:Dennis L. Smith Appointed President and Chief Executive Officer of Solstice Neurosciences, Inc. 2Department of Health & Human Services Names Dr. Eric Rose to National Biodefense Science Board 2
... the denaturation and hybridization steps in slide-based ... clinical and research personnel. The low cost ... types, is easy to use, and reduces ... ensuring overall precision and accuracy in all ...
... RNA Sample Buffer is ... buffer for experimental samples and ... sample buffer needs no dilution ... and denaturing gels. Simply mix ...
... cultured in DMEM and harvested at the log ... the antigens in their native forms, cells were ... on a 12-well (5 mm) adhesive coated slide, ... cellular attachment and to minimize background staining. ...
ID clarifier: Without ethidium bromide...
Biology Products: