Navigation Links
Researcher awarded $1.2 million grant to study centrosomes and cilia
Date:9/22/2009

TALLAHASSEE, Fla. -- If you don't know how a human cell is supposed to work, it's hard to offer a good explanation when the cell goes haywire -- as it does in cancer. That's why a Florida State University College of Medicine researcher has been awarded a $1.2 million grant to explore the role of centrosomes and cilia in cell division and development and their connections to human disease.

Tim Megraw, a veteran researcher who joined the College of Medicine as an associate professor in August, received the four-year grant from the National Institutes of Health this month. The grant continues through August 2013.

The focus of Megraw's work is cell division. Cancer occurs when renegade cells start dividing uncontrollably. Anti-cancer drugs such as Taxol, Megraw noted, target the microtubule, a key molecule that regulates cell division. Along with other areas of focus, he's looking into microtubule regulation and its relationship to another component of the cell called the centrosome.

"We're studying how microtubules are regulated in cells normally," Megraw said, "and the key roles that the centrosomin family of proteins play in this process. Centrosomes are the main centers for organizing microtubules. So we're interested in how centrosomes are assembled and regulated. Both of those goals are outlined in this new grant."

Remarkably, centrosomins regulate not only centrosome assembly and their functions in cytoskeleton assembly, but also the replication of centrosomes in the cell cycle.

This is a continuation of work Megraw and his wife, Ling-Rong Kao, now an assistant in research at the medical school, began in 2003 at the University of Texas Southwestern Medical Center in Dallas. They have explored cells in the brain of the fruit fly and, more recently, the mouse.

Based on their work, researchers better understand the nature of centrosome-based diseases.

"Most of the diseases affect these little hair-like structures that stick out of our cells -- cilia," said Megraw, noting that interest in cilia has experienced a renaissance in recent years. "It's funny because, if you read a review article from 15 or 20 years ago, people wrote statements like 'These appear to be useless vestiges.' And now they appear to be key signaling centers. I have trouble keeping up with the list of diseases that are now associated with defective cilia."

Among those diseases are polycystic kidney disease, as well as other syndromes that lead to deafness, visual degeneration, obesity and primary microcephaly, a condition in which brain development is impaired.


'/>"/>

Contact: Ron Hartung
ronald.hartung@med.fsu.edu
850-645-9205
Florida State University
Source:Eurekalert

Related biology news :

1. Nanoresearchers challenge dogma in protein transportation in cells
2. Ben-Gurion University Alzheimers researcher demonstrates specific immune response to vaccine
3. 1 million euro EU grant for MDC diabetes researcher Dr. Francesca M. Spagnoli
4. MDC researchers discover molecule responsible for axonal branching
5. Cybernetwork to help K-State researchers study tallgrass prairie, respond to global warming
6. UH Manoa researcher examines possible implications of daily commute and mosquito-borne diseases
7. Researchers prolong the half-life of biopharmaceutical proteins
8. Barrow researcher finds natural hydrogel helps heal spinal cord
9. WCMC-Q researchers unlock genetic secrets of date palm
10. Weeding out marijuana: Researchers close in on engineering recognizable, drug-free Cannabis plant
11. Dartmouth researchers get personal with genetics
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/11/2016)... http://www.apimages.com ) - --> http://www.apimages.com ) - ... Images ( http://www.apimages.com ) - Germany . ... new refugee identity cards. DERMALOG will be unveiling this device, and ... Hanover next week.   --> Germany ... the new refugee identity cards. DERMALOG will be unveiling this device, ...
(Date:3/9/2016)... 9, 2016 This BCC Research report provides ... the RNA Sequencing (RNA Seq) market for the years ... tools and reagents, data analysis, and services. ... the RNA-Sequencing market such as RNA-Sequencing tools and reagents, ... factors affecting each segment and forecast their market growth, ...
(Date:3/3/2016)... , March 3, 2016  FlexTech, a SEMI Strategic ... of Innovation, Research & Development, Leadership in Education, and, ... is the 9 th year of the FLEXI ... companies and individuals from past years . Judging ... a pre-described set of criteria, by a panel of ...
Breaking Biology News(10 mins):
(Date:4/29/2016)... ... April 29, 2016 , ... Amendia, Inc., a leading designer, ... announced the completion of a significant transaction and partnership that positions Amendia for ... partners. Kohlberg & Company, L.L.C. (“Kohlberg”), a leading private equity firm specializing ...
(Date:4/29/2016)... ... ... Intelligent Implant Systems announced today that the two-level components for the Revolution™ Spinal ... These components expand the capabilities of the system and allow Revolution™ to be ... 2015, the company has seen significant sales growth in 1Q 2016, and the system ...
(Date:4/28/2016)... ... April 28, 2016 , ... Connecticut Innovations (CI), ... today announced the launch of VentureClash , a $5 million global investment ... “VentureClash looks to attract the best early-stage companies here in Connecticut, around the ...
(Date:4/27/2016)... ... , ... Cambridge Semantics, the leading provider of Smart Data analytic ... been named to The Silicon Review’s “20 Fastest Growing Big Data Companies of 2016.” ... the needs of end users facing some of the most complex data challenges in ...
Breaking Biology Technology: