Navigation Links
Research yields new agent for some drug-resistant non-small cell lung cancers
Date:12/23/2009

D, screened the pyrimidine agents in mice with Iressa- and Tarceva-resistant NSCLC tumors driven by EGFR T790M, and found them to be highly effective at impeding tumor growth. Dana-Farber's Michael Eck, MD, PhD, conducted crystallography studies to determine the molecular structure of the pyrimidines, providing a better picture of why they are so potent and how they target EGFR T790M cells so precisely.

"Not only did we determine that the compound WZ4002 could slow tumor growth, we also demonstrated that it is possible to selectively target the drug-resistant mutant EGFR in tumors, with relatively less effect on the normal EGFR in healthy tissues," says Wong.

Much work remains to determine if WZ4002 and its chemical cousins will be effective therapies, the authors caution, but the discovery demonstrates the power of screening specially designed compounds against cancers with certain genetic quirks.

"Obviously these are very early days with respect to the possible use of these compounds in patients we still have much to learn about their possible liabilities," Eck remarks. "But I am optimistic that our approach is correct and that it will lead to an effective treatment for the thousands of non-small cell lung cancer patients worldwide who development resistance to Iressa and Tarceva every year."


'/>"/>

Contact: Bill Schaller
william_schaller@dfci.harvard.edu
617-632-5357
Dana-Farber Cancer Institute
Source:Eurekalert  

Page: 1 2 3

Related biology news :

1. Scott & White Healthcare researcher finds success with new anti-cancer drug
2. Scott & White Healthcare researcher finds success with new anti-cancer drug
3. Researchers to investigate the genetics of congenital heart disease
4. Poisonous prehistoric raptor discovered by research team from Kansas and China
5. UC Riverside plant scientists research ranked on top ten breakthrough list for 2009
6. Research project yields better understanding of the defective protein that causes cystic fibrosis
7. JDRF announces diabetes research program with Johnson & Johnson
8. Researchers design a tool to induce controlled suicide in human cells
9. Researchers work on vaccine to improve immune system in newborns
10. Springer signs agreement with British Society of Research on Ageing
11. NTU and EDB launch S$50 million ($36 million) integrated circuit design research center
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Research yields new agent for some drug-resistant non-small cell lung cancers
(Date:7/11/2014)... set a "mouse TRAP" to capture the early signs ... published in the Journal of Clinical Investigation . ... TRAP to extract cellular and genetic information from a ... the Rockefeller Institute for Medical Research in 2008, TRAP ... or ribosomes, of the cell type of interest. Scientists ...
(Date:7/11/2014)... 2014---A team of researchers from The Chinese University of ... gene of wild soybean linked to salt tolerance, with ... saline soil. This study published online in Nature ... genomic information for crop improvement. , Soybean is an ... human selection, cultivated soybeans have less genetic diversities than ...
(Date:7/11/2014)... members to reduce aggression and gain access to scarce ... activities shows a certain pattern across the day. The ... Biology Letters . , Grooming between individuals in a ... To be groomed has hygienic benefits and is stress ... provide access to infants, mating opportunities and high quality ...
Breaking Biology News(10 mins):BGI reports a novel gene for salt tolerance found in wild soybean 2Baboons groom early in the day to get benefits later 2
... The origin of the Tahitian vanilla orchid, whose cured fruit ... French Polynesian spice, has long eluded botanists. Known by the ... to exist only in cultivation; natural, wild populations of the ... team of investigators led by Pesach Lubinsky, a postdoctoral researcher ...
... purify the air when they are lit up by ... have discovered. Associate Professor Zhu Huai Yong, from ... glaziers in medieval forges were the first nanotechnologists who ... Professor Zhu said numerous church windows across Europe ...
... for capturing detailed images of the body,s anatomy. Thanks ... Mellon University scientist Eric Ahrens, MRI can be used ... of interest in the living body. The ability to ... will greatly aid the study and treatment of cancer, ...
Cached Biology News:Tahitian vanilla originated in Maya forests, says UC Riverside botanist 2Tahitian vanilla originated in Maya forests, says UC Riverside botanist 3Air-purifying church windows early nanotechnology 2Carnegie Mellon MRI technology that non-invasively locates, quantifies specific cells in the body 2Carnegie Mellon MRI technology that non-invasively locates, quantifies specific cells in the body 3
(Date:7/10/2014)... EvoDerma ’s NOOME Anti-Aging Motion has ... now comes with a second treatment cup to help prevent ... new cup is thinner on the edges for a softer ... thin and uneven surfaces on the face, neck and décolleté. ... treatment on areas such as the cheeks and neck, or ...
(Date:7/10/2014)... PROVO, Utah , July 10, 2014 ... genome annotation and interpretation, today announced an ... sequencing (NGS) analytics for Lineagen,s NextStep Dx ... evaluation of neurodevelopmental and neurological disorders, currently ... chromosomal microarray (CMA) testing service used by ...
(Date:7/10/2014)... D.C., June 17, 2014 Using microscopic polymer ... specific gases, researchers at MIT,s Quantum Photonics Laboratory ... levels in the parts-per-billion range. Optical sensors are ... their high signal-to-noise ratio, compact, lightweight nature, and ... gas sensors had been developed before, the MIT ...
(Date:7/10/2014)... forever. Nanophysics makes sure of that. Mechanics researchers at Linkping ... Physical Review E . Knowledge that can be of ... be able to sit still forever, and walk around upside ... soon be able to buy smart new fasteners that hold ... is, sooner or later the grip is lost, no matter ...
Breaking Biology Technology:Introducing a New Bonus Treatment Cup for EvoDerma’s NOOME Anti-Aging Motion 2Tute Genomics Platform Selected to Provide Clinical Interpretation for Lineagen's NextStepDx PLUS Next-Generation Sequencing-Based Diagnostic Test 2Tute Genomics Platform Selected to Provide Clinical Interpretation for Lineagen's NextStepDx PLUS Next-Generation Sequencing-Based Diagnostic Test 3Tute Genomics Platform Selected to Provide Clinical Interpretation for Lineagen's NextStepDx PLUS Next-Generation Sequencing-Based Diagnostic Test 4Swell new sensors 2Even geckos can lose their grip 2
... Animal Model Shows Disease Progression Can Be Prevented, ... in the December issue of The European Journal of,Immunology ... of,studies made possible under a grant from the Alliance ... lupus-prone mice with a dual,inhibitor of TLR7 and TLR9 ...
... September 30, ... 2007, ... Bulletin Board: CKGT), a vertically integrated,grower, developer, manufacturer and marketer of a ... on November,19, 2007 and reported unaudited results for the period ended September ...
... Inc. (Amex:,SGN - News) has received FDA 510(k) ... its ambulatory event recorder throughout the United States.,This ... 200 HeartLife,Tempo Card, is a direct-to-consumer non-prescription flexible ... used as an early-detection,device by patients who desire ...
Cached Biology Technology:Dynavax Reports Progress in Lupus Program With Inhibitor of TLR7 and TLR9 2Dynavax Reports Progress in Lupus Program With Inhibitor of TLR7 and TLR9 3China Kangtai Cactus Biotech, Inc. Reports Third Quarter 2007 Financial Results 2China Kangtai Cactus Biotech, Inc. Reports Third Quarter 2007 Financial Results 3China Kangtai Cactus Biotech, Inc. Reports Third Quarter 2007 Financial Results 4Signalife Receives FDA Clearance for OTC Non-Prescription Event Recorder Device 2Signalife Receives FDA Clearance for OTC Non-Prescription Event Recorder Device 3
Mouse Anti-Amyloid beta [1-16], clone 6E10, Monoclonal Antibody...
The pCDF Expression System 1 plus Competent Cells contains 10 µg of pET-45b(+) DNA. pET-45b carries an N-terminal His•Tag ® coding sequence that is cleavable with enterokinase as well...
Nucleobindin 1 [NUCB1]...
Request Info...
Biology Products: