Navigation Links
Research uncovers promising target to treat chronic abdominal pain
Date:3/2/2009

d enough about what has gone wrong in these patients," he said.

The antibiotic ceftriaxone used in the study to increase EAAT2 levels may not be optimal IBS therapy because chronic antibiotic use could lead to bacterial resistance and overgrowth of other substances, such as yeast, Stephens said. However, this drug is now in Phase III clinical trials for the treatment of amyotrophic lateral sclerosis, also known as Lou Gehrig's disease.

Stephens is collaborating with other investigators who are studying compounds that have the same effect as the antibiotic in elevating EAAT2. Researchers also are exploring the use of inactive viruses to administer the protein as a therapy. With these methods, viruses are engineered to maintain their invasive abilities without causing an infection, and serve as a delivery system for a therapeutic agent.

The scientists next plan to find out where these key interactions between EAAT2 and glutamate occur. Glutamate is present throughout the body, but Stephens and colleagues believe the spinal cord is the most likely site of action for blunting the pain response.


'/>"/>

Contact: Robert Stephens
Stephens.6@osu.edu
614-292-4706
Ohio State University
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Research shows skeleton to be endocrine organ
2. Newly created cancer stem cells could aid breast cancer research
3. Dominant cholesterol-metabolism ideas challenged by new research
4. Researchers identify proteins involved in new neurodegenerative syndrome
5. Texas researchers and educators head for Antarctica
6. MGH researchers describe new way to identify, evolve novel enzymes
7. University of Pennsylvania researchers develop formula to gauge risk of disease clusters
8. University of Oregon researcher finds that on waters surface, nitric acid is not so tough
9. U of MN researchers discover noninvasive diagnostic tool for brain diseases
10. U of Minnesota researchers discover noninvasive diagnostic tool for brain diseases
11. Story ideas from the Journal of Lipid Research
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/2/2015)... Sweden , April 2, 2015 ... for Q1 2015 attributed to somewhat higher than 125 ... in the year-end report 2014 that revenues for Q1 ... that the company reported for Q4 2014. The operating ... to be negative. The complete interim report will as ...
(Date:4/2/2015)... Sweden , April 2, 2015 ... its touch fingerprint sensor FPC1025 from the distributor World ... will commence during Q2 2015 although the major part ... The sensors will be used by smartphone manufacturers in ... 110 MSEK is included in the communicated revenue guidance ...
(Date:4/1/2015)... Conn. , Apr. 1, 2015  NXT-ID, Inc. ... biometric authentication company focused on the growing mobile commerce ... of Wocket smart wallets is underway to early access ... access group includes usage at retail outlets including Walmart, ... Pharmacy. Users report Wocket was accepted at all outlets ...
Breaking Biology News(10 mins):Fingerprint Cards Revises Revenues for Q1 2015 2Fingerprint Cards Receives Touch Fingerprint Sensor Order of SEK 110 Million 2NXT-ID Reports Second Shipment of Wocket Smart Wallets Underway to Early Access Pre-order Customers and Provides User Feedback 2NXT-ID Reports Second Shipment of Wocket Smart Wallets Underway to Early Access Pre-order Customers and Provides User Feedback 3NXT-ID Reports Second Shipment of Wocket Smart Wallets Underway to Early Access Pre-order Customers and Provides User Feedback 4
... a time when we were paralyzed in the face of ... the right choice can mean the difference between life and ... thing that leads to a "reward," such as food, changes ... those changes has been the focus of Natural Sciences and ...
... into Napoleon Bonaparte's cause of death might finally put ... the illness that killed the French emperor during his ... , American, Swiss and Canadian researchers applied modern ... that Napoleon died of a very advanced case of ...
... of date now that University of Florida scientists discovered a ... , New genera of living birds are rare discoveries ... and Andrew Kratter, ornithologists at the Florida Museum of Natural ... expedition in the Solomon Islands. Theirs is the first frogmouth ...
Cached Biology News:Rewarding fat rats 2Napoleon's mysterious death unmasked, UT Southwestern researcher says 2Napoleon's mysterious death unmasked, UT Southwestern researcher says 3Napoleon's mysterious death unmasked, UT Southwestern researcher says 4UF scientists discover new genus of frogmouth bird in Solomon Islands 2UF scientists discover new genus of frogmouth bird in Solomon Islands 3
(Date:4/2/2015)... 02, 2015 One of the ... avoid false negative results. MultiGEN Diagnostics, LLC (MultiGEN), ... Services, LLC (PCLS), has developed a novel platform ... negatives, while at the same time maintains confirmatory ... combination is expected to improve the quality of ...
(Date:4/2/2015)... 2015 InGaAs PIN photo diodes are ... and high-speed response. Marktech introduces the newest series of ... with active areas of 0.1mm, 0.3mm and 0.8mm. Applications ... high speed fiber modules. , Standard spectral range of ... parts offer considerable speed improvements over the current offerings ...
(Date:4/2/2015)... This section entails current and upcoming opportunities ... and geographic regions, which are expected to retain a high ... period. An increasing demand for IR imaging is expected in ... expected to grow at a CAGR of 6.50% from 2014 ... 123 tables and 58 figers spread through 184 pages and ...
(Date:4/1/2015)... (PRWEB) April 01, 2015 “Science can be ... and fifth-graders participated in an “Introduce a Girl to Engineering ... February. Lessons in light-based science and technology were presented by ... Student Chapters awarded a total of $60,000 in International ... international society for optics and photonics . The IYL grants ...
Breaking Biology Technology:MultiGEN Diagnostics, LLC Announces the Use of IC-Code™ Technology to Eliminate False Negatives in Molecular Diagnosis. 2Marktech Optoelectronics Announces High Speed InGaAs PIN Diode 1.7µm 2Infrared Imaging Market (IR Lens System, IR Detector and Components) Worth $8,450 Million by 2020 - New Report by MarketsandMarkets 2Infrared Imaging Market (IR Lens System, IR Detector and Components) Worth $8,450 Million by 2020 - New Report by MarketsandMarkets 3Fun, wonder, importance of light are messages in SPIE Student Chapter IYL2015 events 2Fun, wonder, importance of light are messages in SPIE Student Chapter IYL2015 events 3
... Senate, my top priority has been growing the state's ... Committee on Job Creation, many pro-job initiatives authored and ... a bi-partisan basis. These bills have improved the state's ... built a foundation for a more vibrant venture capital ...
... University of Wisconsin-Madison faculty and staff interested in launching ... help them through the process of taking a good ... Business Ventures at the University of Wisconsin-Madison," is now ... of the UW-Madison Office of Corporate Relations (OCR). , ...
... even bigger businesses is the theme of the second-annual ... 1-2 in Milwaukee, conference organizers announced Wednesday. The event ... Wisconsin. , ,We must create an entrepreneurial culture in ... and create well-paying jobs, said Kelly Hansen, conference chairwoman ...
Cached Biology Technology:Broadband freedom mandatory for growth 2New guide offers assistance to UW-Madison entrepreneurs 2Entrepreneurs Conference to focus on strategies, tools and culture 2
Recombinant Human HGF...
... Designed to histochemically detect ... distinct pH in cultured ... The specific marker is ... cells (not found in ...
Viral CMV UL146/vCXC1 Biotinylated Affinity Purified PAb...
D-biotin *50 mM aqueous solution* Secondary Detection Biotin–Avidin Detection Reagents Other...
Biology Products: