Navigation Links
Research uncovers promising target to treat chronic abdominal pain
Date:3/2/2009

d enough about what has gone wrong in these patients," he said.

The antibiotic ceftriaxone used in the study to increase EAAT2 levels may not be optimal IBS therapy because chronic antibiotic use could lead to bacterial resistance and overgrowth of other substances, such as yeast, Stephens said. However, this drug is now in Phase III clinical trials for the treatment of amyotrophic lateral sclerosis, also known as Lou Gehrig's disease.

Stephens is collaborating with other investigators who are studying compounds that have the same effect as the antibiotic in elevating EAAT2. Researchers also are exploring the use of inactive viruses to administer the protein as a therapy. With these methods, viruses are engineered to maintain their invasive abilities without causing an infection, and serve as a delivery system for a therapeutic agent.

The scientists next plan to find out where these key interactions between EAAT2 and glutamate occur. Glutamate is present throughout the body, but Stephens and colleagues believe the spinal cord is the most likely site of action for blunting the pain response.


'/>"/>

Contact: Robert Stephens
Stephens.6@osu.edu
614-292-4706
Ohio State University
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Research shows skeleton to be endocrine organ
2. Newly created cancer stem cells could aid breast cancer research
3. Dominant cholesterol-metabolism ideas challenged by new research
4. Researchers identify proteins involved in new neurodegenerative syndrome
5. Texas researchers and educators head for Antarctica
6. MGH researchers describe new way to identify, evolve novel enzymes
7. University of Pennsylvania researchers develop formula to gauge risk of disease clusters
8. University of Oregon researcher finds that on waters surface, nitric acid is not so tough
9. U of MN researchers discover noninvasive diagnostic tool for brain diseases
10. U of Minnesota researchers discover noninvasive diagnostic tool for brain diseases
11. Story ideas from the Journal of Lipid Research
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/26/2015)... 26, 2015 The Granite Club, ... and athletic club, today announced it has implemented a ... of movement for members and staff, while restricting access ... process, we selected FST,s IMID Access system because it ... our members and staff, in addition to unparalleled security," ...
(Date:3/24/2015)... March 24, 2015   Crossmatch ™, a ... announced that its U.are.U ® 4500 Fingerprint ... Goorin Bros . to achieve PCI compliance for ... access to the POS terminal, protecting the retailer ... data breaches. With one-third of ...
(Date:3/23/2015)... , Mar. 23, 2015 NXT-ID, Inc. (NASDAQ: ... focused on the growing mobile commerce market, announces its biometric ... advertising campaign on CNBC television starting March 30 th ... commence airing in New York markets. ... said: "We are excited about our new ad campaign following ...
Breaking Biology News(10 mins):Granite Club First Private Club in North America to Implement FST Biometrics Secure Access Solution, as Part of Multi-million Dollar Expansion 2Crossmatch Fingerprint Readers Help Retailer Prevent Data Breaches at Point-of-Sale 2NXT-ID's Wocket Smart Wallet to Launch New CNBC Regional TV Ad Campaign 2NXT-ID's Wocket Smart Wallet to Launch New CNBC Regional TV Ad Campaign 3
... Researchers at Rice University and Penn State University have ... creating nanotubes turns them into solid, spongy, reusable blocks that ... That,s one of a range of potential innovations for ... for the first time that boron puts kinks and elbows ...
... key to treating one of the most common types ... gene called FLT3, according to new research led by ... Helen Diller Family Comprehensive Cancer Center. Published this ... validates certain activating mutations in the FLT3 gene as ...
... (Boston) An international team of researchers led ... four loci that appear to be associated with decreasing ... region of the brain that plays an important role ... an ability that patients with Alzheimer,s disease lose. The ...
Cached Biology News:Nanosponges soak up oil again and again 2Nanosponges soak up oil again and again 3An Achilles heel of AML 2An Achilles heel of AML 3BUSM researchers identify genes that influence hippocampal volume 2
(Date:5/4/2015)... (PRWEB) May 04, 2015 Genedata, ... drug discovery and life science research, today announced ... the latest version of its enterprise solution for ... R&D enables more efficient discovery and development of ... to integrate and address protein optimization and developability ...
(Date:5/4/2015)... -- China Cord Blood Corporation (NYSE: CO ) ... leading provider of cord blood collection, laboratory testing, hematopoietic ... announced that the Company has been informed that Golden ... Kong listed company and a substantial shareholder ... "Agreement") to purchase the Company,s outstanding 7% senior convertible ...
(Date:5/4/2015)... 2015   Intrexon Corporation (NYSE: XON ... financial results after the market closes on May 11, ... day at 5:30 PM ET to discuss the results ... conference call may be accessed by dialing 1-888-346-3959 (Domestic ... "Intrexon Conference Call."  Participants may also access the live ...
(Date:5/1/2015)... , May 1, 2015  Northwest Biotherapeutics (NASDAQ: ... DCVax® personalized immune therapies for solid tumor cancers, announced ... million second tranche of a $40 million investment from ... Woodford first invested $25 million in NW Bio on ... into an agreement with the Company for a further ...
Breaking Biology Technology:Genedata Biologics 5.0 – Antibody Engineering and Developability Assessment Advances 2Genedata Biologics 5.0 – Antibody Engineering and Developability Assessment Advances 3Genedata Biologics 5.0 – Antibody Engineering and Developability Assessment Advances 4China Cord Blood Corporation Receives Notice of a Transaction Regarding its 7% Senior Convertible Notes Due 2017 Held by KKR 2China Cord Blood Corporation Receives Notice of a Transaction Regarding its 7% Senior Convertible Notes Due 2017 Held by KKR 3Intrexon to Announce First Quarter 2015 Financial Results on Monday, May 11, 2015 2NW Bio Closes On $28.5 Million Second Tranche Of Woodford $40 Million Financing 2NW Bio Closes On $28.5 Million Second Tranche Of Woodford $40 Million Financing 3
... SAN FRANCISCO, September 23 InspireMD, developers of,MGuard(TM), ... in the,Israeli MGuard(TM) Registry. MGuard(TM) was successfully implanted in,Natanya, ... Dr. Yitzhak,Herz, the principal investigator for the Registry at ... MGuard Registry will enroll 100 ,real world, MGuard patients,from ...
... 23 Advanced Health Media LLC (AHM), the leading U.S. ... software for the pharmaceutical industry, announced that it has been ... Top Technology Innovators Across America for 2009. This is ... the country,s most innovative developers of business technology. , ...
... , , RESEARCH TRIANGLE PARK, N.C., ... a partnership with Max Healthcare to open a Phase I/IIa clinical ... proof of concept unit will allow Pharmaceutical, Biotech & Device companies ... across multiple therapeutic areas quickly and with the highest quality. , ...
Cached Biology Technology:InspireMD Announces the Enrollment of the 1st Patient in the MGuard(TM) Israeli Registry. InspireMD Will Also Sponsor a Satellite Program Breakfast Meeting at the TCT Conference on September 24th 2009 in the Moscone Exhibition Center in San Francisco 2InspireMD Announces the Enrollment of the 1st Patient in the MGuard(TM) Israeli Registry. InspireMD Will Also Sponsor a Satellite Program Breakfast Meeting at the TCT Conference on September 24th 2009 in the Moscone Exhibition Center in San Francisco 3Advanced Health Media Named to 2009 InformationWeek 500 List of Top Technology Innovators Across America 2Advanced Health Media Named to 2009 InformationWeek 500 List of Top Technology Innovators Across America 3Advanced Health Media Named to 2009 InformationWeek 500 List of Top Technology Innovators Across America 4Max Neeman International to Open Phase I/IIa Unit 2