Navigation Links
Research uncovers promising target to treat chronic abdominal pain
Date:3/2/2009

d enough about what has gone wrong in these patients," he said.

The antibiotic ceftriaxone used in the study to increase EAAT2 levels may not be optimal IBS therapy because chronic antibiotic use could lead to bacterial resistance and overgrowth of other substances, such as yeast, Stephens said. However, this drug is now in Phase III clinical trials for the treatment of amyotrophic lateral sclerosis, also known as Lou Gehrig's disease.

Stephens is collaborating with other investigators who are studying compounds that have the same effect as the antibiotic in elevating EAAT2. Researchers also are exploring the use of inactive viruses to administer the protein as a therapy. With these methods, viruses are engineered to maintain their invasive abilities without causing an infection, and serve as a delivery system for a therapeutic agent.

The scientists next plan to find out where these key interactions between EAAT2 and glutamate occur. Glutamate is present throughout the body, but Stephens and colleagues believe the spinal cord is the most likely site of action for blunting the pain response.


'/>"/>

Contact: Robert Stephens
Stephens.6@osu.edu
614-292-4706
Ohio State University
Source:Eurekalert

0

GOOD

Page: 1 2 3

Related biology news :

1. Research shows skeleton to be endocrine organ
2. Newly created cancer stem cells could aid breast cancer research
3. Dominant cholesterol-metabolism ideas challenged by new research
4. Researchers identify proteins involved in new neurodegenerative syndrome
5. Texas researchers and educators head for Antarctica
6. MGH researchers describe new way to identify, evolve novel enzymes
7. University of Pennsylvania researchers develop formula to gauge risk of disease clusters
8. University of Oregon researcher finds that on waters surface, nitric acid is not so tough
9. U of MN researchers discover noninvasive diagnostic tool for brain diseases
10. U of Minnesota researchers discover noninvasive diagnostic tool for brain diseases
11. Story ideas from the Journal of Lipid Research
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/16/2013)... shown a gene involved in neurodegenerative disease also plays ... circadian clock. , In a study of the ... Ataxin-2, keeps the clock responsible for sleeping and waking ... of the fruit fly,s sleep-wake cycle is disturbed, making ... fly. , The discovery is particularly interesting because ...
(Date:5/16/2013)... The endothelium, the cellular layer lining the body,s ... few hundred nanometers in thickness, this super-tenuous structure ... tissue compression to create a unique and highly ... partition tissues from the body,s circulatory system. , ... barrier must be physically breached to enable ...
(Date:5/16/2013)... sports players and athletes choose to wear the color ... published in Psychological Science , a journal of ... have to do with their testosterone levels. , The ... the University of Sunderland and colleagues, demonstrated that males ... task had higher testosterone levels than other males who ...
Breaking Biology News(10 mins):Gene involved in neurodegeneration keeps clock running 2Endothelium, heal thyself 2Endothelium, heal thyself 3Endothelium, heal thyself 4High-testosterone competitors more likely to choose red 2
... calling for levels of obesity among South Asians to be ... Leicester. A team from the University,s Departments of ... the point at which South Asians should be classed as ... in PLoS One , a journal of the Public ...
... Institute ( http://cmi.vt.edu/ ), a research center within ... has provided technical expertise for the world,s first ... Degradation (REDD) project to receive certification under the ... http://www.v-c-s.org/ ). The UN-REDD Programme ( http://www.un-redd.org/ ) ...
... a tasteless, colorless and odorless gas, is not only a ... beings. Found in the exhaust of vehicles and generators, CO ... lethal, poisoning the nervous system and heart. Now, ... University,s Department of Geography and the Human Environment has discovered ...
Cached Biology News:New research calls for lower limit to be set for South Asian obesity level 2First UN carbon offset project certified 2Carbon monoxide -- the silent calmer? 2
(Date:5/17/2013)... The paradigm of ‘one drug, one target’ ... help predict the adverse and therapeutic effects of a ... Computational Biology at the Genomics Laboratory, Covance, will discuss ... genomics when used as part of the QC process. ... sets to identify key clinical targets even in complex ...
(Date:5/17/2013)... WA (PRWEB) May 17, 2013 Tooth decay ... graders showing active signs of the disease. The World Health ... and nearly 100% of adults have cavities. What are the ... is showing a strong connection between the oral bacterial ... is this disease so rampant, yet it is also 100% ...
(Date:5/16/2013)... Zealand (PRWEB) May 16, 2013 In late ... invited to speak to doctors in China about Appearance ... and NZ, this was her first trip to lecture in ... Hart visited Guangzhou and Fuzhou, home to 12 and 7 ... China is very high at this point in time. As ...
(Date:5/16/2013)... PORTLAND, Ore. , May 16, 2013 /PRNewswire/ ... to many of the nation,s largest regional health ... the America,s Health Insurance Plans (AHIP) Institute 2013 ... and highlight survey results showing how health insurance ... planning for the consumer and marketplace demands for ...
Breaking Biology Technology:Seeing the Future: How a Revolutionary New Bacterial Screening Device Can Predict a Patient’s Future for Tooth Decay 2Seeing the Future: How a Revolutionary New Bacterial Screening Device Can Predict a Patient’s Future for Tooth Decay 3HealthSparq to Reveal New Healthcare Transparency Benchmark Study at AHIP Institute 2013 2HealthSparq to Reveal New Healthcare Transparency Benchmark Study at AHIP Institute 2013 3
... the H1N1 flu virus, could help to ease future vaccine ... with the flu virus. In a study published ... Breath Research , researchers have investigated an easy, non-invasive breath ... H1N1 strain. Research published last month claimed that ...
... 14, 2011 BioMarin Pharmaceutical Inc. (Nasdaq: BMRN ... for BMN 673, a poly ADP-ribose polymerase (PARP) inhibitor, for ... 1/2 trial for BMN 673 for the treatment of patients ... ongoing. "We are excited to be at ...
... Quest Diagnostics (NYSE: DGX ), ... and services, and Genomic Vision, a biotechnology company dedicated ... a multi-year exclusive collaboration involving Genomic Vision,s proprietary ... terms of the agreement, Quest Diagnostics has exclusive ...
Cached Biology Technology:'Swine flu' breath test could reduce future vaccination shortages, research suggests 2BioMarin Initiates Phase 1 Trial for BMN 673 in Patients With Advanced Hematological Malignancies 2BioMarin Initiates Phase 1 Trial for BMN 673 in Patients With Advanced Hematological Malignancies 3Quest Diagnostics and Genomic Vision Form Strategic Collaboration to Develop Genome-based Laboratory Tests 2Quest Diagnostics and Genomic Vision Form Strategic Collaboration to Develop Genome-based Laboratory Tests 3Quest Diagnostics and Genomic Vision Form Strategic Collaboration to Develop Genome-based Laboratory Tests 4
Bis-Acrylamide (bis) is a monomer used as a crosslinker with acrylamide to form polyacrylamide electrophoretic gels. This 2% bis solution is supplied as 500 ml....
... EnVision™ G|2 Doublestain System is a ... visualization kit. The kit is intended ... simultaneous detection of two different antigens ... compatible with suitably diluted rabbit and ...
AVOID FREEZE/THAW CYCLES. Recognizes the UCP-2 protein....
Rabbit Anti-Human Janus Kinase 2 (JAK2 Polyclonal Antibody Family: Protein Kinase Sub-Family: TYK2/JAK Applications: ELISA, Western Blot...
Biology Products: