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Research uncovers promising target to treat chronic abdominal pain
Date:3/2/2009

d enough about what has gone wrong in these patients," he said.

The antibiotic ceftriaxone used in the study to increase EAAT2 levels may not be optimal IBS therapy because chronic antibiotic use could lead to bacterial resistance and overgrowth of other substances, such as yeast, Stephens said. However, this drug is now in Phase III clinical trials for the treatment of amyotrophic lateral sclerosis, also known as Lou Gehrig's disease.

Stephens is collaborating with other investigators who are studying compounds that have the same effect as the antibiotic in elevating EAAT2. Researchers also are exploring the use of inactive viruses to administer the protein as a therapy. With these methods, viruses are engineered to maintain their invasive abilities without causing an infection, and serve as a delivery system for a therapeutic agent.

The scientists next plan to find out where these key interactions between EAAT2 and glutamate occur. Glutamate is present throughout the body, but Stephens and colleagues believe the spinal cord is the most likely site of action for blunting the pain response.


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Contact: Robert Stephens
Stephens.6@osu.edu
614-292-4706
Ohio State University
Source:Eurekalert

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