Navigation Links
Research uncovers promising target to treat chronic abdominal pain
Date:3/2/2009

et at it with these therapies," Stephens said.

The research is published in a recent issue of the American Journal of Physiology Gastrointestinal and Liver Physiology.

Stephens and colleagues tested the effects of higher-than-normal levels of EAAT2 in two different types of mice. They used mice genetically engineered to produce an excess of the protein as well as normal mice that were treated with an antibiotic already known to generate extra EAAT2 in the body. The transgenic mice had about twice the normal level of EAAT2, and those treated with the drug produced between 40 percent and 80 percent more of the protein than would a normal mouse.

Both the transgenic mice and mice treated with the antibiotic that increases EAAT2 experienced less pain than did control mice that had normal levels of EAAT2 in their system. In both types of mice with elevated levels of EAAT2, the pain response was reduced by approximately 50 percent to 70 percent compared to the pain levels in normal mice.

To further prove that EAAT2 was responsible for the reduced pain response, the scientists pretreated mice with dihydrokainate (DHK), a compound known to block the effects of that particular protein. The DHK significantly reversed the blunted pain response in mice with elevated levels of EAAT2.

Stephens said this approach appears to be effective for visceral pain only, and not for somatic pain, which is pain resulting from injuries to the skin, superficial tissues or muscles and bones.

The transgenic mice engineered to contain higher-than-normal levels of the protein are otherwise healthy. Stephens said that observation, combined with the fact EAAT2 does not affect somatic pain, suggest the protein is a good candidate for a therapy specifically designed to treat visceral pain.

"The drugs we have now aren't good. Really, all that's available is symptomatic treatment for irritable bowel syndrome. We just don't understan
'/>"/>

Contact: Robert Stephens
Stephens.6@osu.edu
614-292-4706
Ohio State University
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Research shows skeleton to be endocrine organ
2. Newly created cancer stem cells could aid breast cancer research
3. Dominant cholesterol-metabolism ideas challenged by new research
4. Researchers identify proteins involved in new neurodegenerative syndrome
5. Texas researchers and educators head for Antarctica
6. MGH researchers describe new way to identify, evolve novel enzymes
7. University of Pennsylvania researchers develop formula to gauge risk of disease clusters
8. University of Oregon researcher finds that on waters surface, nitric acid is not so tough
9. U of MN researchers discover noninvasive diagnostic tool for brain diseases
10. U of Minnesota researchers discover noninvasive diagnostic tool for brain diseases
11. Story ideas from the Journal of Lipid Research
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/30/2014)... LA JOLLAJoseph Ecker, a Salk professor and Howard ... staff scientist, have been named recipients in the ... of Health (NIH) through the BRAIN (Brain Research ... in neuroscience. The grant, announced September 30, provides ... Salk scientists over three years. , The BRAIN ...
(Date:9/30/2014)... German . ... foods in the world. Because they grow underground, people use ... smell of truffles is not only of interest to gourmets. ... of the Goethe University Frankfurt have discovered that the smell ... are trapped inside truffle fruiting bodies. , White truffles from ...
(Date:9/30/2014)... Having trouble getting pregnanteven with IVF? Here,s some hope: ... of The FASEB Journal , explains ... protein known as PAWP, which induced embryo development in ... of embryo development by the sperm cell during fertilization. ... represent a major paradigm shift in our understanding of ...
Breaking Biology News(10 mins):Salk scientists receive $3 million for BRAIN Initiative grant 2On the trail of the truffle flavor 2Synthetic sperm protein raises the chance for successful in vitro fertilization 2
... vagina can vary greatly between healthy women, according to ... School of Medicine,s Institute for Genome Sciences. Researchers hope ... women, allowing doctors to tailor each woman,s treatment and ... The study, published online the week of May 31, ...
... of phytonutrients thought to promote health could add a new ... to fork can be a perilous one fraught with sundry ... in the ground or during storage. In Aberdeen, Idaho, ... are taking on the late-blight fungus, Phytophthora infestans , ...
... rare practice by red squirrels that seems to have human-like ... survival tactic. U of A researcher Jamieson Gorrell ... had adopted a newborn squirrel abandoned by its biological mother. ... a baby red squirrel had been taken from its mother-absent ...
Cached Biology News:UM School of Medicine study finds vaginal microbes vary among healthy women 2UM School of Medicine study finds vaginal microbes vary among healthy women 3ARS scientists seek blight-resistant spuds 2Red squirrels: Altruists or self-serving survivalists? 2
(Date:9/30/2014)... 2014 SoundConnect, an ... is dedicated to supporting business communication solutions, including ... Power, a carrier services specialist has ... stays connected and productive at all times. This ... of businesses to cloud communications services. On ...
(Date:9/30/2014)... Back in the 1970’s, many companies calculated their office ... included space for circulation and file storage. “It was ... Nidea Corporate Real Estate / ITRA Global , a ... however, 250 square feet per employee became the norm. ... 175 to 225 square feet, and over the next few ...
(Date:9/29/2014)... VIRGINIA BEACH, Va. , Sept. 29, 2014 ... scientists from the fields of cartilage repair, regeneration, ... as attendees from around the world gathered to ... 2014 LifeNet Health Institute of Regenerative Medicine symposium, ... Future Direction . Topics included Orthopedic Biosurgery, Minced ...
(Date:9/29/2014)... DUBLIN , Sept. 29, 2014 ... "Process Liquid Analyzer, Gas Analyzer, and Gas Chromatograph ... Application, & Region - Global Trends & Forecast to ... A process analyzer is a process analytical ... in real-time. It has redefined the way by which ...
Breaking Biology Technology:SoundConnect Expands Carrier Services Division 2ITRA Global Reports on How Companies Are Squeezing More Employees into Less Office Space 2ITRA Global Reports on How Companies Are Squeezing More Employees into Less Office Space 3World Renowned Experts Discuss Future Of Cartilage Regeneration 2World Renowned Experts Discuss Future Of Cartilage Regeneration 3Global Process Liquid Analyzer, Gas Analyzer, and Gas Chromatograph (PH/ORP, Chlorine, Oxygen, Carbon dioxide) Market - Trends & Forecast to 2020 2Global Process Liquid Analyzer, Gas Analyzer, and Gas Chromatograph (PH/ORP, Chlorine, Oxygen, Carbon dioxide) Market - Trends & Forecast to 2020 3Global Process Liquid Analyzer, Gas Analyzer, and Gas Chromatograph (PH/ORP, Chlorine, Oxygen, Carbon dioxide) Market - Trends & Forecast to 2020 4
... pharmaceutical and biotechnology ... specialist expertise, BOSTON, Jan. 3 Observant LLC ... passion for research excellence,and a commitment to client service. ... the firm as Vice President. Dr. Hartman,s,research has focused ...
... in orbit and the National Aeronautics and Space Administrations ... observe the Earths environment to help predict and prevent ... of remote sensing technology aids specialists in predicting the ... infectious diseases today such as Ebola, West Nile virus ...
... WEST LAFAYETTE, Ind. - Researchers have developed a ... "biosensors," a tool that could help industry perfect ... to environmental monitoring. , The experimental devices represent ... capture and detect specific "target molecules," which will ...
Cached Biology Technology:Observant LLC Expands Senior Management Team 2NASA technology helps predict and prevent future pandemic outbreaks 2Model is first to compare performance of 'biosensors' 2Model is first to compare performance of 'biosensors' 3
CHIMAERIC HUMAN IgA2 ANTI NP...
ANTI NO-TRYPTOPHAN CONJUGATE...
... The Captivate magnetic separator ... be used in conjunction with ... C-21474, C-21476) or other magnetic ... most 96-well microplates. Cell Biology ...
Protein Phosphorylation...
Biology Products: