Navigation Links
Research uncovers potential preventive for central line infection
Date:9/11/2013

A team of researchers at Cincinnati Children's Hospital Medical Center has developed an antibody that could prevent Candida infections that often afflict hospitalized patients who receive central lines.

Margaret Hostetter, MD, director of infectious diseases at Cincinnati Children's, and her team developed the antibody, which prevents Candida albicans from binding to heparin, thereby stopping the formation of biofilm in a rat model of catheter-associated infection. A biofilm is a multi-layered buildup of millions of microorganisms that coat the inside of the catheter

The study was published online in July in the Journal of Infectious Diseases.

Earlier research by Hostetter's team showed that heparin binds to Candida albicans, a yeast that resides on our skin and in our gastrointestinal tract. Candida uses its ability to bind heparin to elude the body's immune response and to form biofilms. When biofilms form on the inside of catheters, groups of microorganisms can break off into the bloodstream and cause serious infections.

"Standard anticoagulants used in catheters may facilitate biofilm formation by microbes," says Dr. Hostetter. "Understanding this process can lead to new strategies for prevention of line infections."

In hospitalized patients with central venous catheters, Candida albicans may gain entrance to the body and form a biofilm in a central venous catheter. When a biofilm disperses, the yeast will enter the bloodstream and may be carried to other organs, such as the kidneys, the liver, or the spleen.

When the antibody is modified to be compatible with humans, clinical trials of the treatment can begin in humans, says Dr. Hostetter.

Collaborators on the study included researchers from Duke University Medical Center, the University of Cincinnati and the University of Wisconsin.


'/>"/>

Contact: Jim Feuer
jim.feuer@cchmc.org
513-636-4656
Cincinnati Children's Hospital Medical Center
Source:Eurekalert

Page: 1

Related biology news :

1. Study by UC Santa Barbara researchers suggests that bacteria communicate by touch
2. Research reveals first evidence of hunting by prehistoric Ohioans
3. Diabetes Research Institute develops oxygen-generating biomaterial
4. APS issues new policy requiring identification of sex or gender in reporting scientific research
5. UC Santa Barbara researchers discover genetic link between visual pathways of hydras and humans
6. Study jointly led by UCSB researcher supports theory of extraterrestrial impact
7. U of Alberta researcher steps closer to understand autoimmune diseases
8. Research on flavanols and procyanidins provides new insights into how these phytonutrients may positively impact human health
9. A project to research biological and chemical aspects of microalgae to fuel approach
10. Scripps Research discoveries lead to newly approved drug for infant respiratory distress syndrome
11. Researchers attempt to solve problems of antibiotic resistance and bee deaths in one
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/24/2014)... Carbon offsetting initiatives could be improved with new insights ... , Scientists studying the Amazon Basin have revealed ... trees across the region by comparing satellite maps with ... enable researchers to assess more accurately the amount of ... factor in carbon offset schemes, in which trees are ...
(Date:4/23/2014)... analysis of NASA satellite data shows Africa,s Congo rainforest, ... a large-scale decline in greenness over the past decade. ... at Albany, State University of New York, shows between ... of forest area and intensified. The research, published Wednesday ... comprehensive observational studies to explore the effects of long-term ...
(Date:4/23/2014)... from the Indiana University School of Public Health-Bloomington has ... disease by finding a strong association between heme iron, ... disease. , The study found that heme iron consumption ... percent, while no association was found between nonheme iron, ... coronary heart disease. , The study was published online ...
Breaking Biology News(10 mins):Amazon rainforest survey could improve carbon offset schemes 2NASA satellites show drought may take toll on Congo rainforest 2NASA satellites show drought may take toll on Congo rainforest 3Study: Iron consumption can increase risk for heart disease 2
... , NEW YORK (Nov. 3, 2010) -- Scientists at Weill ... better understanding of prostate cancer by uncovering evidence that it ... factors which can be measured and, in the future, destroyed ... research team led by of Dr. Mark A. Rubin, the ...
... and Columbia University Medical Center have been awarded a ... B. Helmsley Charitable Trust, establishing a collaborative program to ... to gain new insight into disease mechanisms and screen ... of immense importance to the future of biomedical research ...
... defects in plants can be predicted based on chromosome ... the addition or deletion of genes and the organization ... involving a Purdue University researcher. The findings identify ... chromosomes, said Brian Dilkes, a Purdue assistant professor of ...
Cached Biology News:Prostate cancer's multiple personalities revealed 2Helmsley Charitable Trust awards more than $15 million to Salk Institute-CUMC 2Helmsley Charitable Trust awards more than $15 million to Salk Institute-CUMC 3Chromosome imbalances lead to predictable plant defects 2
(Date:1/15/2014)... (PRWEB) January 15, 2014 Cynvenio, a ... management through the genomic analysis of tumor cells in ... Finder™, a web-based cancer decision support application powered by ... with Cynvenio’s ClearID™ genomic test, Therapy Finder will provide ...
(Date:1/15/2014)... A study has been launched to test whether technology ... help to tackle the problem of obesity.  This unique healthcare ... based in Stowmarket) and academics at University Campus Suffolk is ... which is inspired by equipment used to collect data about ...
(Date:1/15/2014)... 2014 DTS Language Services, Inc . ... Portal for Life Science organizations who need document translations. ... matter of their documents in advance with a selection of ... of translations, often a critical factor in clinical and scientific ...
(Date:1/15/2014)... , Jan. 15, 2014 TaiGen Biotechnology Company, Limited ... agreement with R-Pharm, a leading Russian pharmaceutical company, to ... Russian Federation , Turkey ... States (CIS). Nemonoxacin is a novel antibiotic for the treatment ...
Breaking Biology Technology:Cynvenio Offers New Breast Cancer Therapy Finder Application for its ClearID Breast Cancer Genomic Test 2Cynvenio Offers New Breast Cancer Therapy Finder Application for its ClearID Breast Cancer Genomic Test 3Formula 1 Technology Tackles Obesity in Unique Healthcare Partnership 2Formula 1 Technology Tackles Obesity in Unique Healthcare Partnership 3Formula 1 Technology Tackles Obesity in Unique Healthcare Partnership 4DTS Improves Efficiency for Life Science Document Translations 2TaiGen Biotechnology Signed Exclusive License Agreement with R-Pharm for Nemonoxacin (Taigexyn(R)) 2TaiGen Biotechnology Signed Exclusive License Agreement with R-Pharm for Nemonoxacin (Taigexyn(R)) 3TaiGen Biotechnology Signed Exclusive License Agreement with R-Pharm for Nemonoxacin (Taigexyn(R)) 4
... Scott Stevens, Ph.D. , ... Scott Stevens, Ph.D ., assistant professor of molecular ... at Austin,1 University Station, #A4800,2500 Speedway,Austin,TX , ... scott.stevens@mail.utexas.edu. , ...
... By Julia Cino, PhD ... Introduction , ... to manipulate DNA to identify,excise, move and place genes into a variety ... use for many of these recombinant organisms is to produce,proteins. Since many ...
... , , ... , This Application Report ... BioFlo 110,benchtop fermentor/bioreactor system. The modular,BioFlo 110 is offered with ... wide variety of cultures, including mammalian, insect,plant, yeast and bacterial cells. Complete ...
Cached Biology Technology:Fermentation Cell Culture: University Style 2Fermentation Cell Culture: University Style 3Fermentation Cell Culture: University Style 4Fermentation Cell Culture: University Style 5Fermentation Cell Culture: University Style 6Fermentation Cell Culture: University Style 7Fermentation Cell Culture: University Style 8Fermentation Cell Culture: University Style 9High Yield Protein Production from Pichia pastoris Yeast: A Protocol for Benchtop Fermentation 2High Yield Protein Production from Pichia pastoris Yeast: A Protocol for Benchtop Fermentation 3High Yield Protein Production from Pichia pastoris Yeast: A Protocol for Benchtop Fermentation 4High Yield Protein Production from Pichia pastoris Yeast: A Protocol for Benchtop Fermentation 5High Yield Protein Production from Pichia pastoris Yeast: A Protocol for Benchtop Fermentation 6High Yield Protein Production from Pichia pastoris Yeast: A Protocol for Benchtop Fermentation 7High Yield Protein Production from Pichia pastoris Yeast: A Protocol for Benchtop Fermentation 8Hybridoma Cell Culture Application Using a BioFlo 110 Benchtop Bioreactor 2Hybridoma Cell Culture Application Using a BioFlo 110 Benchtop Bioreactor 3Hybridoma Cell Culture Application Using a BioFlo 110 Benchtop Bioreactor 4Hybridoma Cell Culture Application Using a BioFlo 110 Benchtop Bioreactor 5Hybridoma Cell Culture Application Using a BioFlo 110 Benchtop Bioreactor 6
Immunochemistry 1 & 2...
Hucal Agx Antigen Expression Service Specificity: Hucal Agx ...
... The 1-D PAGE ... Kit for Targeted Protein ... SDS PolyAcrylamide Gel Electrophoresis ... chemistry, and cleavable-linker technology ...
Antibody Purification Specificity: Antibody Purification ...
Biology Products: