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Research uncovers key to understanding cause of lupus
Date:1/31/2011

us much later, at 9 months of age.

Findings show that all three lupus strains manifest a common dysregulated pattern of miRNAs despite differences in their background genes. Importantly, this expression of miRNAs became evident only at an age when the mice manifest lupus.

The identification of these common miRNAs presents a new way of understanding lupus development. The researchers at the veterinary college believe these studies will potentially open a new approach for diagnosis and treatment of the illness by altering lupus-specific miRNAs in lymphocytes.

"In the short term, we want to use our better understanding of the disease to develop a tool in the form of molecular markers for early, reliable diagnosis," said Ahmed. The long-term goal, Ahmed added, is to offer entirely new therapeutic approaches, such as manipulation of lupus-related miRNA, to correct pathological conditions.

Having identified signature miRNA changes in lupus disease, the next step for the researchers is to prove they can really switch off the disease.

"If we can do this in a mouse model and then to cure other animals, hopefully it can one day be done in humans. This is long-range research but modern technology is narrowing the time it takes from mouse to human speeding translation," said Ahmed.


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Contact: Eric McKeeby
emckeeby@vt.edu
540-231-7911
Virginia Tech
Source:Eurekalert  

Page: 1 2

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