Navigation Links
Research uncovers key to understanding cause of lupus
Date:1/31/2011

Potentially impacting future diagnosis and treatment of lupus, an immune illness affecting more than 5 million people worldwide, researchers at the Virginia-Maryland Regional College of Veterinary Medicine at Virginia Tech have likely uncovered where the breakdown in the body's lymphocyte molecular regulatory machinery is occurring.

Rujuan Dai, research scientist, and her colleagues in the veterinary college's Department of Biomedical Sciences and Pathobiology, have discovered a "common set of dysregulated miRNAs in murine lupus models." The research, which appears in the Dec. 13, 2010, issue of the scientific journal PLoS One, was funded in part by the Lupus Foundation of America.

Lupus is a chronic autoimmune disease of connective tissue that causes the body's immune system to become hyperactive and attack normal, healthy tissue. This results in symptoms such as inflammation, swelling, and possible damage to joints, skin, kidneys, blood, the heart, or lungs.

In an effort to better understand epigenetic factors in the causes of lupus, researchers at the veterinary college focused on microRNA (miRNA), seeking to determine potential impairments of genetic regulation. These small RNAs control gene expression by directly regulating specific target messenger RNAs via inhibition of their translation or inducing their degradation.

"Micro RNAs perform these duties in an orderly fashion," said S. Ansar Ahmed, professor of immunology and head of the Department of Biomedical Sciences and Pathobiology at the college. "White blood cells use miRNA to regulate antibodies and other proteins in response to infection or any kind of assault."

The researchers chose three strains of autoimmune-prone mice that have different background genomes and manifest lupus-like disease at different ages. For example, one mouse strain began developing lupus-like disease around 3 months of age, and another mouse strain developed severe lupus much later, at 9 months of age.

Findings show that all three lupus strains manifest a common dysregulated pattern of miRNAs despite differences in their background genes. Importantly, this expression of miRNAs became evident only at an age when the mice manifest lupus.

The identification of these common miRNAs presents a new way of understanding lupus development. The researchers at the veterinary college believe these studies will potentially open a new approach for diagnosis and treatment of the illness by altering lupus-specific miRNAs in lymphocytes.

"In the short term, we want to use our better understanding of the disease to develop a tool in the form of molecular markers for early, reliable diagnosis," said Ahmed. The long-term goal, Ahmed added, is to offer entirely new therapeutic approaches, such as manipulation of lupus-related miRNA, to correct pathological conditions.

Having identified signature miRNA changes in lupus disease, the next step for the researchers is to prove they can really switch off the disease.

"If we can do this in a mouse model and then to cure other animals, hopefully it can one day be done in humans. This is long-range research but modern technology is narrowing the time it takes from mouse to human speeding translation," said Ahmed.


'/>"/>

Contact: Eric McKeeby
emckeeby@vt.edu
540-231-7911
Virginia Tech
Source:Eurekalert  

Related biology news :

1. Wistar Institute researcher receives New Innovator award from NIH
2. NC State researchers get to root of parasite genome
3. White Mountain Research Station to host climate change conference
4. Stevens awarded $1M for advanced biofuels research
5. Researchers find animal with ability to survive climate change
6. Researchers find an essential gene for forming ears of corn
7. Researchers note differences between people and animals on calorie restriction
8. Researcher working on destruction of chemical weapons
9. Researchers study acoustic communication in deep-sea fish
10. Researchers discover that growing up too fast may mean dying young in honey bees
11. The Rett Syndrome Research Trust launches operations
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Research uncovers key to understanding cause of lupus
(Date:5/16/2017)... 2017   Bridge Patient Portal , an ... MD EMR Systems , an electronic medical record ... have established a partnership to build an interface ... GE Centricity™ products, including Centricity Practice Solution (CPS), ... These new integrations will allow healthcare delivery networks ...
(Date:4/18/2017)... -- Socionext Inc., a global expert in SoC-based imaging and computing solutions, ... which features the company,s hybrid codec technology. A demonstration utilizing TeraFaces ... will be showcased during the upcoming Medtec Japan at Tokyo Big ... Las Vegas Convention Center April 24-27. ... Click here for an image of ...
(Date:4/11/2017)... Fla. , April 11, 2017 ... and secure authentication solutions, today announced that it ... Intelligence Advanced Research Projects Activity (IARPA) to develop ... Thor program. "Innovation has been a ... IARPA,s Thor program will allow us to innovate ...
Breaking Biology News(10 mins):
(Date:10/11/2017)... ... ... Disappearing forests and increased emissions are the main causes of the evolving air ... living in larger cities are affected by air pollution related diseases. , That is ... globally - decided to take action. , “I knew I had to take action ...
(Date:10/10/2017)... Philadelphia, PA (PRWEB) , ... October 10, 2017 ... ... University City Science Center’s FirstHand program has won a US2020 STEM Mentoring Award. ... accept the award for Excellence in Volunteer Experience from US2020. , US2020’s mission ...
(Date:10/10/2017)... ... October 10, 2017 , ... The Pittcon Program Committee ... honoring scientists who have made outstanding contributions to analytical chemistry and applied ... the world’s leading conference and exposition for laboratory science, which will be held ...
(Date:10/9/2017)... ... October 09, 2017 , ... ... medical journal, Epilepsia, Brain Sentinel’s SPEAC® System which uses the surface electromyography ... generalized tonic-clonic seizures (GTCS) using surface electromyography (sEMG). The prospective multicenter phase ...
Breaking Biology Technology: