Navigation Links
Research uncovers key to understanding cause of lupus
Date:1/31/2011

Potentially impacting future diagnosis and treatment of lupus, an immune illness affecting more than 5 million people worldwide, researchers at the Virginia-Maryland Regional College of Veterinary Medicine at Virginia Tech have likely uncovered where the breakdown in the body's lymphocyte molecular regulatory machinery is occurring.

Rujuan Dai, research scientist, and her colleagues in the veterinary college's Department of Biomedical Sciences and Pathobiology, have discovered a "common set of dysregulated miRNAs in murine lupus models." The research, which appears in the Dec. 13, 2010, issue of the scientific journal PLoS One, was funded in part by the Lupus Foundation of America.

Lupus is a chronic autoimmune disease of connective tissue that causes the body's immune system to become hyperactive and attack normal, healthy tissue. This results in symptoms such as inflammation, swelling, and possible damage to joints, skin, kidneys, blood, the heart, or lungs.

In an effort to better understand epigenetic factors in the causes of lupus, researchers at the veterinary college focused on microRNA (miRNA), seeking to determine potential impairments of genetic regulation. These small RNAs control gene expression by directly regulating specific target messenger RNAs via inhibition of their translation or inducing their degradation.

"Micro RNAs perform these duties in an orderly fashion," said S. Ansar Ahmed, professor of immunology and head of the Department of Biomedical Sciences and Pathobiology at the college. "White blood cells use miRNA to regulate antibodies and other proteins in response to infection or any kind of assault."

The researchers chose three strains of autoimmune-prone mice that have different background genomes and manifest lupus-like disease at different ages. For example, one mouse strain began developing lupus-like disease around 3 months of age, and another mouse strain developed severe lup
'/>"/>

Contact: Eric McKeeby
emckeeby@vt.edu
540-231-7911
Virginia Tech
Source:Eurekalert  

Page: 1 2

Related biology news :

1. Wistar Institute researcher receives New Innovator award from NIH
2. NC State researchers get to root of parasite genome
3. White Mountain Research Station to host climate change conference
4. Stevens awarded $1M for advanced biofuels research
5. Researchers find animal with ability to survive climate change
6. Researchers find an essential gene for forming ears of corn
7. Researchers note differences between people and animals on calorie restriction
8. Researcher working on destruction of chemical weapons
9. Researchers study acoustic communication in deep-sea fish
10. Researchers discover that growing up too fast may mean dying young in honey bees
11. The Rett Syndrome Research Trust launches operations
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Research uncovers key to understanding cause of lupus
(Date:12/15/2014)... , Dec. 12, 2014 Research and Markets ... addition of the "Global Facial Recognition Market ... http://photos.prnewswire.com/prnh/20130307/600769 Facial ... of individuals. Facial recognition system measures the overall ... jaw edges, mouth, and the distance between eyes. ...
(Date:12/11/2014)... 2014 Research and Markets ... ( http://www.researchandmarkets.com/research/9ql3kr/biometrics_market ) has announced the addition of ... report to their offering. One ... adoption of multimodal biometric systems. Multimodal biometric systems ... for verification and identification purposes. This helps to ...
(Date:12/11/2014)... Minn. , Dec. 10, 2014  Data ... physiologic monitoring, has released a new series of ... of preclinical toxicology researchers. M series, part of ... toxicologists collect the best possible physiologic data when ... Adding functional endpoints to toxicology studies has ...
Breaking Biology News(10 mins):Global Facial Recognition Market 2015-2019: Key Vendors are 3M Cogent, Cognitec Systems, NEC and Safran Group 2Global Facial Recognition Market 2015-2019: Key Vendors are 3M Cogent, Cognitec Systems, NEC and Safran Group 3Biometrics Market in India 2015-2019: Key Vendors are 3M Cogent, NEC, Safran and Suprema 2New telemetry implants expected to change how large animal toxicology studies are conducted 2
... of the biological effects of Antarctic icebergs shows that they ... take up carbon dioxide from the atmosphere and then, through ... process is detailed in 19 new research papers published electronically ... Research Part II: Topical Studies in Oceanography . The ...
... Applied Ecology received EPA funding to develop a design-feasibility ... The study, being done in collaboration with Clemson,s ... Development and the city of Charleston, will evaluate the ... farm, powering it with solar and wind energy and ...
... marine species at or near the top of their ... bodies when they live and feed in waters near ... Marine Laboratory (HML), a government-university collaboration in Charleston, S.C. ... Environmental Science & Technology , one research team ...
Cached Biology News:Antarctic icebergs help the ocean take up carbon dioxide 2Antarctic icebergs help the ocean take up carbon dioxide 3Clemson University institute to study 'vertical farming' feasibility in Charleston, S.C. 2Clemson University institute to study 'vertical farming' feasibility in Charleston, S.C. 3Marine lab research tracks pollutants in dolphins and beluga whales 2Marine lab research tracks pollutants in dolphins and beluga whales 3
(Date:12/15/2014)... METTLER TOLEDO is pleased to announce that ... with PVM technology , is now available. The ... tool continuously captures high-resolution images under a wide ... prepares a report pairing the most relevant images ... This compelling blend of high resolution images and ...
(Date:12/15/2014)...  Ascendis Pharma A/S, a biotechnology company that ... unmet medical needs, today announced positive six-month interim ... to evaluate once-weekly TransCon Growth Hormone in children ... analysis consists of 25 patients, representing approximately 50% ... completing all six months of treatment. ...
(Date:12/13/2014)... Taiwan (PRWEB) December 12, 2014 Trend ... indicators in overall global economic growth, Eugene Arthurs, CEO ... photonics , said in a featured talk at OPTIC ... December at the National Chung Hsing University in Taichung. ... being integrated into future energy supplies and soon to ...
(Date:12/13/2014)... --Research and Markets ( http://www.researchandmarkets.com/research/6p4j9m/glucose_sensors ) ... Sensors: the Next Generation" report to their ... The convergence of small-scale electronics and ... a better future to millions of diabetes patients ... levels accurately and reliably have the capability to ...
Breaking Biology Technology:New Real-Time In Situ Probe-Based Video Microscope from METTLER TOLEDO 2Ascendis Pharma A/S Announces Positive Six-Month Interim Results from a Phase 2 Pediatric Study of Once-Weekly TransCon Growth Hormone for the Treatment of Growth Hormone Deficiency 2Ascendis Pharma A/S Announces Positive Six-Month Interim Results from a Phase 2 Pediatric Study of Once-Weekly TransCon Growth Hormone for the Treatment of Growth Hormone Deficiency 3Ascendis Pharma A/S Announces Positive Six-Month Interim Results from a Phase 2 Pediatric Study of Once-Weekly TransCon Growth Hormone for the Treatment of Growth Hormone Deficiency 4Photonics Continues Upward Trends Despite Challenges in the Global Economy, Notes SPIE CEO 2Photonics Continues Upward Trends Despite Challenges in the Global Economy, Notes SPIE CEO 3Photonics Continues Upward Trends Despite Challenges in the Global Economy, Notes SPIE CEO 4Photonics Continues Upward Trends Despite Challenges in the Global Economy, Notes SPIE CEO 5Glucose Sensors: the Next Generation 2Glucose Sensors: the Next Generation 3
... (OTCQX: DATA), a technology and services company focused on ... announces the expansion of its DATATRAK Academy to include ... license its DATATRAK eClinical® software suite. DTCC students and ... Trials Research program and courses. The software is used ...
... 2011 The Laboratory Department for Probiotics Research ... (NAGATA Satoru, YAMASHIRO Yuichiro et al.) studied supplementation ... Shirota (LcS) in elderly individuals living at a ... acute norovirus gastroenteritis. Analysis of ...
... Md., May 9, 2011 The Maryland Technology Enterprise ... University of Maryland $75K Business Plan Competition . ... and faculty teams were selected from 71 initial entries and ... teams of expert judges as well as a public audience ...
Cached Biology Technology:DATATRAK Academy Expands to Include Durham Technical Community College 2DATATRAK Academy Expands to Include Durham Technical Community College 3Lactobacillus Beverage Confirmed to Reduce Fever Brought on by Acute Gastroenteritis Caused by Norovirus Infection 2Lactobacillus Beverage Confirmed to Reduce Fever Brought on by Acute Gastroenteritis Caused by Norovirus Infection 3Mtech Announces Winners of the 2011 University of Maryland $75K Business Plan Competition 2Mtech Announces Winners of the 2011 University of Maryland $75K Business Plan Competition 3Mtech Announces Winners of the 2011 University of Maryland $75K Business Plan Competition 4Mtech Announces Winners of the 2011 University of Maryland $75K Business Plan Competition 5
Agarose-LE, 250 g. Suitable for soft agarose cloning. Nuclease-free.Gel point (1.5%): 36 1.5 C, EEO (-mr): 1200 g/cm2. Category: Nucleotides & Enzymes & Biochemicals, Ultrapure Biochemicals ....
IC50: 3 ng/ml · Limit of detection: 0.9 ng/ml...
Request Info...
Image Analysis Software. PC Version of NIH Image....
Biology Products: