Navigation Links
Research team uncovers root cause of multiple myeloma relapse
Date:9/18/2013

PHOENIX, Ariz. Sept. 18, 2013 Researchers have discovered why multiple myeloma, a difficult to cure cancer of the bone marrow, frequently recurs after an initially effective treatment that can keep the disease at bay for up to several years.

Working in collaboration with colleagues at Princess Margaret Hospital in Toronto, researchers from Mayo Clinic in Arizona and the Translational Genomics Research Institute (TGen) in Phoenix were part of the team that conducted the study published in the Sept. 9 issue of Cancer Cell.

The research team initially analyzed 7,500 genes in multiple myeloma cells to identify genes which when suppressed made cancer cells resistant to a common class of drugs called proteasome inhibitors such as bortezomib or carfilzomib. Then, the team studied bone marrow biopsies from patients to further understand their results. The process identified two genes (IRE1 and XBP1) that control response to the proteasome inhibitor and the mechanism underlying the drug resistance that is the barrier to cure.

The findings showed recurrence was due to an intrinsic resistance found in immature tumor progenitor (mother) cells is the root cause of the disease and also spawns relapse. The research demonstrates that although the visible cancer cells that make up most of the tumor are sensitive to the proteasome inhibitor drug, the underlying progenitor cells are untouched by this therapy. These progenitor cells then proliferate and mature to reboot the disease process, even in patients who appeared to be in complete remission.

"Our findings reveal a way forward toward a cure for multiple myeloma, which involves targeting both the progenitor cells and the plasma cells at the same time," says Rodger Tiedemann, M.D., a hematologist specializing in multiple myeloma and lymphoma at Princess Margaret. "Now that we know that progenitor cells persist and lead to relapse after treatment, we can move quickly into clini
'/>"/>

Contact: Steve Yozwiak
syozwiak@tgen.org
602-343-8704
The Translational Genomics Research Institute
Source:Eurekalert

Page: 1 2

Related biology news :

1. RIKEN and leading Indian institutions launch Joint Research Centers
2. Rensselaer researchers create accurate computer model of RNA tetraloop
3. Hypertension researcher encourages colleagues to expand their focus
4. Researchers hit virtual heads to make safer games
5. DiscoveRx Announces Launch of New Human Primary Cell-Based Panels for Oncology Research
6. Entomological Society of America names winners of Monsanto student travel and research awards
7. Research uncovers potential preventive for central line infection
8. UAlberta medical researchers discover how immune system kills healthy cells
9. Turfgrass research has a field day
10. UCI researchers fabricate new camouflage coating from squid protein
11. Researchers uncover genetic cause of childhood leukemia
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/10/2014)...  Wake Forest Baptist Medical Center today announced plans for ... Medicine. Funding for this $50 million capital project is ... publicly launched next summer. The medical ... series R.J. Reynolds Tobacco Company complex, adjacent to 525@vine ... with plans to be ready to welcome medical students ...
(Date:12/5/2014)... -- Tute Genomics, a leader in cloud-based solutions for genome ... led by UK-based Eurovestech. Peak Ventures and a number ... "We are at a pivotal time in ... seeks new approaches for the diagnosis, treatment and prevention ... and CEO of Tute Genomics. "One of the main ...
(Date:11/21/2014)... 2014  Earlier this year Donald Spector , ... one of the most prolific inventors in the world, ... from Smartphones to third party agencies. Spector envisioned this ... of the earliest known patents in this area. Now ... military, child care, elder care and hospital applications. This ...
Breaking Biology News(10 mins):Wake Forest Baptist to Build New Medical Education Facility In Wake Forest Innovation Quarter 2Wake Forest Baptist to Build New Medical Education Facility In Wake Forest Innovation Quarter 3Wake Forest Baptist to Build New Medical Education Facility In Wake Forest Innovation Quarter 4Tute Genomics Raises $2.3 Million to Scale Up Cloud-Based Genome Analytics and Accelerate Personalized Medicine 2Tute Genomics Raises $2.3 Million to Scale Up Cloud-Based Genome Analytics and Accelerate Personalized Medicine 3Patented Biosensor Wearable Technology Provides a More Civilized Method of Quarantine 2Patented Biosensor Wearable Technology Provides a More Civilized Method of Quarantine 3Patented Biosensor Wearable Technology Provides a More Civilized Method of Quarantine 4
... born 200 years ago come Feb. 12, but his theory ... while the Origin of Species author might not have known ... the environment is changing. He would, however, be astonished by ... "Every species is under temporary permanence," says Bill Saidel, an ...
... dependent on fish imports. This situation is due in part to ... of fish stocks, which have also been observed in Sweden. The ... high prices lead to a decrease in consumption, which in turn ... diet. The fact that we make use of fish stocks in ...
... The February 2009 issue of BioScience includes ... Centers and Systems Biology. , Yufeng Wang and ... data from the few bacteria in resource collections that ... for which there exist genetic sequence data, using ideas ...
Cached Biology News:Evolution and climate change research advances at Rutgers-Camden 2Research project to boost European fish farming 2BioScience tip sheet, February 2009 2
(Date:12/19/2014)... FL (PRWEB) December 18, 2014 ... the nation’s leading specialty pharmacies, has an expanded ... as clinical pharmacy consultants for prescriber offices in ... expertise. , “We have a variety of ... For example, those specializing in hepatitis C help ...
(Date:12/19/2014)... December 18, 2014 iLab Solutions, the ... appointment of Siri Bryant as the new Director of ... of Core Implementations. These two new leadership positions were ... service by ensuring that iLab continues to meet the ... last four years, iLab has been deployed at over ...
(Date:12/19/2014)... 2014 Egenix, Inc. is pleased to announce that ... the Board, to succeed Donald Fresne ; Mr. Fresne ... as a member of the Board.  In recognition of the ... company over almost twenty years, the Board designated Mr. Fresne ... has established a Search Committee to find a suitable replacement ...
(Date:12/17/2014)... Washington, USA (PRWEB) December 16, 2014 ... Baum, manager at Philipps- Universität Marburg’s Department of ... and photonics, in the newly released SPIE ... “And never be too shy to ask questions.” ... (science, technology, engineering, and mathematics) occupations ranging from ...
Breaking Biology Technology:BioPlus Specialty Pharmacy Expands ‘Regional Pharmaceutical Care Liaison’ Team 2BioPlus Specialty Pharmacy Expands ‘Regional Pharmaceutical Care Liaison’ Team 3iLab Solutions Announces Two New Leadership Positions to Meet the Needs of Its Growing Customer Base 2Network, Multitask, Persevere: SPIE Women in Optics Planner Subjects Share from Experience 2Network, Multitask, Persevere: SPIE Women in Optics Planner Subjects Share from Experience 3
... England, November 10, 2011 Arecor, ... for proteins, peptides and vaccines, is pleased to ... Chief Operating Officer.  Dr Howell will be responsible for ... developing and maintaining Arecor,s upward growth curve ensuring ...
... (NASDAQ: SQNM ), a life sciences company providing ... the Lazard Capital Markets 8th Annual Healthcare Conference at the ... Harry F. Hixson, Jr, Ph.D., Chairman and CEO, and ... Development, will present on Tuesday, November 15, 2011 beginning at ...
... electrons, but tweezers made of electrons. A recent paper* by ... and the University of Virginia (UVA) demonstrates that the beams ... to look at nanoscale objects, but to move them around, ... say, the tool is an electron version of the laser ...
Cached Biology Technology:Arecor Appoints Dr. Sarah Howell as Chief Operating Officer 2Sequenom Announces Participation at the Lazard Capital Markets 8th Annual Healthcare Conference 2Are electron tweezers possible? Apparently so 2
... to significantly increase the shelf life of ... increased at room temperature storage conditions in ... is subjected to 0.45 micron filtration, and ... formulation insures consistently high levels of activity ...
... I provides a convenient and affordable alternative ... Used with an eight-port disposable manifold, the ... with multi-channel pipettes. The eight-port manifold, designed ... of 100, 200, 250, or 300mL with ...
...
... Frame products feature a dual strength adhesive system ... after use. The adhesives on either side of ... which adheres to the glass has an easy ... the coverslip, forms a stronger bond. This means ...
Biology Products: