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Research team targets self-cannibalizing cancer cells
Date:2/11/2010

its way downstream."

The project complements clinical trials investigating ways to modulate autophagy in cancer cells, some of which are already under way at CINJ. One study is assessing whether adding hydroxycholoroquine, an anti-malaria drug known to have autophagy-blocking activity, to standard therapy for recurrent colon cancer will increase the number of cancers that go into remission or boost the length of remission.

"The ultimate test will be to take all of our findings and use that information to develop novel approaches for eradicating cancer," White said. "If we can prevent tumor cells from utilizing this altered metabolic state then that should be the Achilles' heel of tumors."

The cutting-edge research effort demonstrates the merits of the collaboration between Princeton and CINJ, which developed through a natural progression driven by science.

"By uniting Princeton's expertise in systems biology, genomics and metabolism with CINJ's top-rate cancer molecular biology and clinical expertise, these collaborations provide opportunities for interaction that promises what the National Cancer Institute has been encouraging translational research that harnesses basic discoveries for the prevention and treatment of cancer," said James Broach, a Princeton professor of molecular biology who directs the partnership in collaboration with CINJ Deputy Director Edmund Lattime.

"For years our world-class scientists at both facilities have been collaborating on individual cancer research projects," Lattime said. "By entering into a formal partnership, we are strengthening our team science approach so that we can collectively advance cancer research in New Jersey. This will enhance the development of the most innovative, cutting edge cancer treatments for patients in New Jersey and beyond. "

The partnership has already generated groundbreaking results: Last year, a group of Princeton and CINJ researchers led by Prince
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Contact: Kitta MacPherson
kittamac@princeton.edu
609-258-5729
Princeton University
Source:Eurekalert  

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