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Research team explores how microbial diversity defends against disease
Date:11/8/2011

Amphibians are among the most threatened creatures on earth, with some 40 percent of amphibian species threatened or endangered. One of their primary threats is a rapidly spreading disease that attacks the skin cells of amphibians. "Chytridiomycosis, a fungal disease, has been a key factor in the extinctions of many species of frogs around the world," said Lisa Belden, associate professor of biological sciences in the College of Science at Virginia Tech.

Belden is leading a team of researchers from Tech, James Madison University, Villanova University, and the Smithsonian Institution who will study the microbial communities living on the skins of frogs that are surviving the fungal scourge. The effort is one of 11 new Dimensions of Biodiversity projects funded by the National Science Foundation (NSF) with the aim of transforming, by 2020, "how scientists describe and understand the scope and role of life on earth," according to an NSF news release.

For Belden's team, the lofty goals will be achieved through hands on work in Panama, where the spread of chytrid fungus has been extensively documented. Researchers will swab the skin of frogs in areas with and without chytrid to collect samples of the microbes that live there. They will then release the frogs and assess the microbial community, both in terms of what microbes are there and what they are doing functionally on the skin. To see what microbes are there, researchers will examine their DNA. To see what the microbes are doing, researchers will examine how well they inhibit the growth of the chytrid fungus, and also assess what chemical metabolites are being produced by the microbes. "We expect that in the presence of chytrid fungus, there will be strong selection for the bacteria to produce anti- chytrid fungus metabolites, regardless of what bacterial species are present on the skin," said Belden.

It is all about appreciating the diverse roles of microbes, Belden said. "
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Contact: Susan Trulove
strulove@vt.edu
540-231-5646
Virginia Tech
Source:Eurekalert  

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