Research team discovers genetic variance in cancer protection from st... (40 candidate genes known to be important...)

Research team discovers genetic variance in cancer protection from statin drugs

Date:4/21/2010

40 candidate genes known to be important for synthesis and metabolism of cholesterol in people who participated in a population case-control study of colorectal cancer in northern Israel. Included were 1,780 colon cancer patients and 1,863 people who did not have colorectal cancer, and many of the participants, who were predominantly Caucasian, had used statins for a long time. In the initial study, statin use was associated with a 50 percent relative risk of developing colorectal cancer in this population.

Included in the 40 genes were six SNPs, or DNA sequences, within the HMGCR gene, which produces a critical enzyme involved in formation of cholesterol.

They found one SNP within HMGCR that was associated with statin protection against colorectal cancer. A follow-up pharmacogenetic analysis showed that the protective association was significantly stronger among individuals with what they dubbed the "A" SNP allele, or variant, compared with people who had a "T" variant. Because a person inherits two variants, one from each parent, the stronger colorectal cancer protection came from individuals with the A/A HMGCR genotype, compared with those with the T/T genotype. Individuals with an A/T genotype had intermediate protection against colorectal cancer -- levels that varied between that seen for A/A and T/T genotypes.

Dr. Lipkin estimates that, in this Caucasian population, 56 percent had at least one A allele in that HMGCR genomic position.

They then tested, in laboratory colorectal cancer cells, why the T allele might not work well with statins, and found that the protein produced by this HMGCR gene variant does not bind on to the statin like the A allele does, due to "alternative splicing" -- the production of a protein that is slightly altered.

"Carriers of the A allele express more of the full-length protein that binds statins, and are therefore more sensitive to statins and are more likely to experience the colorect
'/>"/>

Contact: Andrew Klein
ank2017@med.cornell.edu
212-821-0560
New York- Presbyterian Hospital/Weill Cornell Medical Center/Weill Cornell Medical College
Source:Eurekalert

0

GOOD

Page: 1 2 3
Related biology news :

1. Research shows skeleton to be endocrine organ
2. Newly created cancer stem cells could aid breast cancer research
3. Dominant cholesterol-metabolism ideas challenged by new research
4. Researchers identify proteins involved in new neurodegenerative syndrome
5. Texas researchers and educators head for Antarctica
6. MGH researchers describe new way to identify, evolve novel enzymes
7. University of Pennsylvania researchers develop formula to gauge risk of disease clusters
8. University of Oregon researcher finds that on waters surface, nitric acid is not so tough
9. U of MN researchers discover noninvasive diagnostic tool for brain diseases
10. U of Minnesota researchers discover noninvasive diagnostic tool for brain diseases
11. Story ideas from the Journal of Lipid Research

Post Your Comments:

(Date:5/21/2013)... alter the way genes function without changing the ... the blood of pregnant women during any trimester, ... in the weeks after giving birth, and an ... The findings of the small study involving 52 ... Molecular Psychiatry . , "Postpartum depression can ...

(Date:5/20/2013)... the lungs of the planet, inhales carbon dioxide as it ... grow parts that eventually fall to the ground to decompose ... , Until recently people believed much of the rain forest,s ... in the ocean. University of Washington research showed a decade ... though left open the question of how that was possible, ...

(Date:5/20/2013)... Bristol and published online today in the Journal ... brain and inner ear developed in dinosaurs. , ... with Tom Hbner from the Niederschsische Landesmuseum in Hannover, ... dinosaurs. , The two palaeontologists studied different fossils of ... young (juvenile) individual of approximately three years of ...

Breaking Biology News(10 mins):Genetic predictors of postpartum depression uncovered by Hopkins researchers 2 Genetic predictors of postpartum depression uncovered by Hopkins researchers 3 Amazon River exhales virtually all carbon taken up by rain forest 2 Amazon River exhales virtually all carbon taken up by rain forest 3 Fossil brain teaser 2

[0] Genetic predictors of postpartum depression uncovered by Hopkins researchers [0] Amazon River exhales virtually all carbon taken up by rain forest [0] Fossil brain teaser

... Dengue illness, the most common mosquito-borne viral disease in ... and is resurgent in countries such as Argentina, Chile ... economic burden of dengue (pronounced DENgee) in the Western ... researchers published today in the American Journal of ...

... satisfied with everyday life and are involved in leisure ... from the University of Gothenburg, Sweden. Occupational therapist ... how everyday life affects alcohol consumption as part of ... study which has been ongoing at the Sahlgrenska Academy ...

... , Using mathematical concepts, Princeton researchers have developed a ... diseases by calculating which physical properties of biological molecules ... already has identified several potential new drugs that were ... by researchers at Johns Hopkins University. "The power ...

Cached Biology News:Brandeis study shows economic impact of dengue virus in Americas 2 Brandeis study shows economic impact of dengue virus in Americas 3 Brandeis study shows economic impact of dengue virus in Americas 4 Women involved in leisure activities drink less alcohol 2 Math may help calculate way to find new drugs for HIV and other diseases 2 Math may help calculate way to find new drugs for HIV and other diseases 3

Brandeis study shows economic impact of dengue virus in Americas Women involved in leisure activities drink less alcohol Math may help calculate way to find new drugs for HIV and other diseases

(Date:5/21/2013)... The congress of the ERA-EDTA (European Renal Association ... congress in Europe on nephrology ... Istanbul to share their knowledge ... have been presented: / (1) Gupta, A ... REDUCES ESA USE" By SFP-iron administration, the ...

(Date:5/21/2013)... 2013 Clinverse, Inc. , ... clinical trials, announced today it has formed a ... Clinverse’s ClinPay® FLS eClinical commerce platform aggregates data ... SpendMD ™, Aggregate Spend Solutions’ recently-launched flagship ... and reporting transfer of value at investigator meetings ...

(Date:5/21/2013)... 21, 2013 According to a ... http://www.transparencymarketresearch.com ) "Biochip Products and Services Market (Microarrays, Reagents, ... Analysis, Size, Share, Growth, Trends and Forecast, 2012 - 2018," the market ... is expected to grow at a CAGR of 10.1% ... of USD 4.7 billion in 2018. Browse ...

(Date:5/21/2013)... 2013 Many have long discussed the ... acne. Recently physicians from Clinical Psychiatry.com readdressed ... the skin, and suggested using hypnotherapy and ... produced from stress that cause acne. , Doctors in ... acne brings about, stress causes changes in the skin ...

Breaking Biology Technology:ERA-EDTA CONGRESS 2013: Late Breaking Clinical Trials 2 ERA-EDTA CONGRESS 2013: Late Breaking Clinical Trials 3 Clinverse, Inc. Announces Strategic Alliance with Aggregate Spend Solutions, LLC 2 Clinverse, Inc. Announces Strategic Alliance with Aggregate Spend Solutions, LLC 3 The U.S. Biochip Products and Services Market is Expected to Reach USD 4.7 Billion in 2018: Transparency Market Research 2 The U.S. Biochip Products and Services Market is Expected to Reach USD 4.7 Billion in 2018: Transparency Market Research 3 The U.S. Biochip Products and Services Market is Expected to Reach USD 4.7 Billion in 2018: Transparency Market Research 4 The U.S. Biochip Products and Services Market is Expected to Reach USD 4.7 Billion in 2018: Transparency Market Research 5 Adult Acne Treatment, Probiotic Action Explains How Hypnotherapy and Probiotics May Cure Various Skin Conditions 2

[0] ERA-EDTA CONGRESS 2013: Late Breaking Clinical Trials [0] Clinverse, Inc. Announces Strategic Alliance with Aggregate Spend Solutions, LLC [0] The U.S. Biochip Products and Services Market is Expected to Reach USD 4.7 Billion in 2018: Transparency Market Research [0] Adult Acne Treatment, Probiotic Action Explains How Hypnotherapy and Probiotics May Cure Various Skin Conditions

... an Antipsychotic Agent with Less Potential for ... Gain and Metabolic Risks, SAN DIEGO, July 29 ... that the United States Patent and,Trademark Office (USPTO) issued ... provide broad coverage for a pharmaceutical,composition of zonisamide in ...

... (Amex: IMA ), a global leader in rapid ... quarter,ended June 30, 2008., In the second quarter ... compared to net revenue of $155.0 million in the ... to increased,product and service revenue in our Professional Diagnostics ...

... S6973 allows up to 50% sucrose reduction while maintaining the sweet ... ... DIEGO, CA, July 29, 2008 Senomyx, Inc.,(Nasdaq: SNMX ), ... novel flavor ingredients for the food, beverage,and ingredient supply industries, announced ...

OREXIGEN(R) Therapeutics Receives Notice of Allowance for U.S. Patent Covering the Composition of Matter in OREX-003 Inverness Medical Innovations Announces Second Quarter 2008 Results SENOMYX ANNOUNCES INITIATION OF DEVELOPMENT ACTIVITIES FOR NEW SUCROSE ENHANCER

... MagCellect Ferrofluid products perform optimally ... R&D Systems MagCellect Magnet. To ... neodymium iron boron permanent magnet ... 75 mm test tubes or ...

... 0 (or Cap 0-like) RNA into Cap ... been shown to increase in vivo translation ... is seen in Cap 0 structures created ... well as those Cap 0 structures created ...

Request Info...

Form: Ready to use Applications: Western Blot, ELISA...

Biology Products:

MagCellect Magnet from R&D Systems ScriptCap 2'-O-Methyltransferase from EPICENTRE Biotechnologies Streptavidin, Alkaline Phosphatase conjugated/tagged from AbD Serotec TMB ONE DILUENT from AbD Serotec