Navigation Links
Research team clarifies mechanics of first new cell cycle to be described in more than 20 years
Date:10/30/2011

SEATTLE An international team of researchers led by investigators in the U.S. and Germany has shed light on the inner workings of the endocycle, a common cell cycle that fuels growth in plants, animals and some human tissues and is responsible for generating up to half of the Earth's biomass. This discovery, led by a geneticist at Fred Hutchinson Cancer Research Center and reported Oct. 30 in Nature, leads to a new understanding of how cells grow and how rates of cell growth might be increased or decreased, which has important implications in both agriculture and medicine.

"It can be argued that this is the first completely novel cell cycle to be elucidated in more than a two decades," said Bruce Edgar, Ph.D., corresponding author of the paper and a member of the Basic Sciences Division at the Hutchinson Center, referring to the groundbreaking description of the mitotic cell cycle in the same journal in the late 1980s.

Mitosis is the division of a mother cell into two daughter cells that contain identical sets of chromosomes. Endocycling, in contrast, is a special type of cell cycle that skips mitosis. The cell replicates its DNA over and over again without ever dividing into two cells. Endocycles play a crucial role in nature because they generate very large cells in invertebrate animals and plants, as well as some human tissues, such as liver and muscle. Most cells in plants and invertebrate animals such as insects, crustaceans (such as shrimp), mollusks (such as clams, oysters and snails) grow by endocycling.

"When a cell goes through an endocycle, it doubles its DNA, and typically also doubles its size and protein content," said Edgar, also a professor at the Center for Molecular Biology and the German Cancer Research Center in Heidelberg, Germany. "Because of this, one could imagine that promoting just one extra endocycle in the cells of a crop plant or farmed shellfish might double the agricultural yield from that crop," h
'/>"/>

Contact: Kristen Woodward
kwoodwar@fhcrc.org
206-667-5095
Fred Hutchinson Cancer Research Center
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Wistar Institute researcher receives New Innovator award from NIH
2. NC State researchers get to root of parasite genome
3. White Mountain Research Station to host climate change conference
4. Stevens awarded $1M for advanced biofuels research
5. Researchers find animal with ability to survive climate change
6. Researchers find an essential gene for forming ears of corn
7. Researchers note differences between people and animals on calorie restriction
8. Researcher working on destruction of chemical weapons
9. Researchers study acoustic communication in deep-sea fish
10. Researchers discover that growing up too fast may mean dying young in honey bees
11. The Rett Syndrome Research Trust launches operations
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/24/2015)... Fla. , March 24, 2015   ... management solutions, today announced that its U.are.U ® ... accessory retailer Goorin Bros . to achieve ... biometrics-based solution secures access to the POS terminal, ... increased risk of data breaches. ...
(Date:3/23/2015)...  In the 2014 fiscal year, irs.gov recorded over ... figure accounts for a fraction of the estimated losses ... exceeds $11 billion globally. The polygraph has traditionally been ... occurred. Investor Mark Saint Juste along with ... partnered to administer the test in a new ...
(Date:3/20/2015)... --Research and Markets ( http://www.researchandmarkets.com/research/rswjb4/hand_geometry ) has announced ... Business Report" report to their offering. This ... Thousands. The report provides separate comprehensive analytics for the US, ... Europe , Asia-Pacific , ... Annual estimates and forecasts are provided for the ...
Breaking Biology News(10 mins):Crossmatch Fingerprint Readers Help Retailer Prevent Data Breaches at Point-of-Sale 2Polygraph Test Now Used to Protect Investors From Fraud 2Polygraph Test Now Used to Protect Investors From Fraud 3Hand Geometry - Global Strategic Business Report 2015: An Essential Security Component for both Government & Enterprise Sector 2Hand Geometry - Global Strategic Business Report 2015: An Essential Security Component for both Government & Enterprise Sector 3Hand Geometry - Global Strategic Business Report 2015: An Essential Security Component for both Government & Enterprise Sector 4
... of poor rice farmers and consumers in Asia have received ... While the world's trading nations remain deadlocked on how to ... farmers of the developing world, research just published has confirmed ... planet's two most populous countries, China and India. , The ...
... damaged heart muscle tissue . . . regenerate injured bone ... . even reverse nerve damage. Human stem cells offer tremendous ... and a variety of other human health problems. , Up ... ethical controversy -- as well as by the rarity of ...
... emerged field of bacterial riboswitches may be a good ... to a report by Yale researchers in the journal ... control gene expression in essential metabolic pathways. Researchers in ... Henry Ford II Professor of Molecular, Cellular and ...
Cached Biology News:Some good news for the world's poor 2Some good news for the world's poor 3Some good news for the world's poor 4From one cell, many possible cures 2From one cell, many possible cures 3Switching to new anti-bacterial targets: Riboswitches 2
(Date:4/16/2015)... San Francisco, CA (PRWEB) April 16, 2015 ... is scheduled to report first quarter results on Thursday, ... the announcement, Cytokinetics’ senior management will host a conference ... and financial results and the company’s outlook for the ... and can be accessed from the homepage and in ...
(Date:4/16/2015)... 16, 2015 According to the ... an outside source was ranked first among the ... related to lifting, pushing, pulling, holding, carrying, or ... costs. The David Round Company takes statistics like ... working hard to develop and design equipment that ...
(Date:4/16/2015)... 16, 2015  RegeneRx Biopharmaceuticals, Inc. (OTCQB: RGRX) ... joint venture with G-treeBNT (ReGenTree LLC) has retained ... trial for the orphan disorder, neurotrophic keratopathy (NK), ... eye syndrome (DES) in the U.S.  Both trials ... this year.  Each of these eye disorders was ...
(Date:4/16/2015)... Calif. , April 16, 2015  Scientists from ... "New Drugs on the Horizon," at the American Association ... Philadelphia, PA on Sunday, April 19, 2015 ... Ph.D., Cleave,s Director of Biology, will present new in ... a first-in-class, oral inhibitor of p97, a critical enzyme ...
Breaking Biology Technology:Cytokinetics to Announce First Quarter Results on April 30, 2015 2Cytokinetics to Announce First Quarter Results on April 30, 2015 3The David Round Company Helps Companies Meet OSHA Standards by Combining Safety, Ergonomics, and Productivity 2RegeneRx JV Retains Ora, Inc. to Conduct Phase 3 Trial for NK and Phase 2b/3 Trial for Dry Eye Syndrome in U.S. 2RegeneRx JV Retains Ora, Inc. to Conduct Phase 3 Trial for NK and Phase 2b/3 Trial for Dry Eye Syndrome in U.S. 3RegeneRx JV Retains Ora, Inc. to Conduct Phase 3 Trial for NK and Phase 2b/3 Trial for Dry Eye Syndrome in U.S. 4RegeneRx JV Retains Ora, Inc. to Conduct Phase 3 Trial for NK and Phase 2b/3 Trial for Dry Eye Syndrome in U.S. 5Cleave Biosciences to Participate in Special Session "New Drugs on the Horizon" at AACR Annual Meeting 2015 2Cleave Biosciences to Participate in Special Session "New Drugs on the Horizon" at AACR Annual Meeting 2015 3
... will receive the Johnson & Johnson Dr. Paul Janssen Award ... a series of events that celebrate his central role in ... signaling molecule of angiogenesis. His research has opened the door ... combat a serious eye disorder and contributed to the development ...
... 13Researchers at Vanderbilt University have developed a new technique that ... tissue at multiple points simultaneously, a method that could help ... and change shape. UV lasers are a commonly-used ... incisions by vaporizing one point at a time in a ...
... 2011 Saladax Biomedical, Inc., a privately held company ... promise of personalized medicine for new and existing therapeutics, ... of Saladax, will be presenting at the Annual UBS ... York in New York City on Tuesday, September 20, ...
Cached Biology Technology:Johnson & Johnson Symposium Honors 2011 Recipient of The Dr. Paul Janssen Award for Biomedical Research 2Johnson & Johnson Symposium Honors 2011 Recipient of The Dr. Paul Janssen Award for Biomedical Research 3Johnson & Johnson Symposium Honors 2011 Recipient of The Dr. Paul Janssen Award for Biomedical Research 4Johnson & Johnson Symposium Honors 2011 Recipient of The Dr. Paul Janssen Award for Biomedical Research 5Saladax Biomedical, Inc. to Present at the Annual UBS Global Life Sciences Conference in New York City 2
... AC is the easiest to program ... provided with liquid level sensors for ... integrated orbital shaker and automatic rinsing ... performance. The big bottle model is ...
The Wellwash 4 Mk 2 microplate washer combines flexibility, simplicity and ease of use. This reliable microplate washer meets the exacting standards of today's ELISA assay requirements....
... Benzonase Nuclease is a genetically engineered endonuclease. ... DNA and RNA while having no proteolytic ... range of conditions and possesses an exceptionally ... nucleic acids from recombinant proteins, its use ...
... genome-wide microRNA expression profiling and built ... microfluidic on-chip synthesis platform. These microarrays ... comprehensive microRNA Expression Profiling Service. ... microRNA Microarray contains all known rice ...
Biology Products: